Abstract
DJ-1 is a gene involved in various cellular processes, including transcriptional regulation, oxidative stress response, fertilization, mitochondrial regulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1 also plays a critical role in tumor development and progression. In this review, we provide an overview of current knowledge concerning the role and the mechanism of DJ-1 in cancer and also discuss the possibility of DJ-1 as a therapeutic target against cancer.
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Cao, J., Chen, X., Ying, M., He, Q., Yang, B. (2017). DJ-1 as a Therapeutic Target Against Cancer. In: Ariga, H., Iguchi-Ariga, S. (eds) DJ-1/PARK7 Protein. Advances in Experimental Medicine and Biology, vol 1037. Springer, Singapore. https://doi.org/10.1007/978-981-10-6583-5_13
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