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Surface Modification of Tissue Engineering Scaffolds

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Polymeric Biomaterials for Tissue Regeneration

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Abstract

The biomaterial surface is typically engineered to elicit appropriate cellular responses. This chapter deals with commonly used methods to modify and characterise biomaterial surfaces. The first part describes surface modification technologies, broadly categorised into physical methods (comprising topographical and wettability engineering approaches) and chemical methods (comprising substantial chemical manipulation, such as plasma-based methods). In the second part, methods for the characterisation of the material are presented. These include physical assessments, where visualisation of the modified surfaces is performed, chemical assessments aimed at identifying changes in molecular compositions and, finally, biological evaluation, with a focus on cytocompatibility as an important preliminary evaluation of safety of the modified material.

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  1. Nanyang Technological University, Singapore, Singapore

    Feng Wen, Charles Chau Sang Lau, **g Lim, Yanwan Liao, Swee Hin Teoh & Mark Seow Khoon Chong

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    Changyou Gao

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Wen, F., Lau, C.C.S., Lim, J., Liao, Y., Teoh, S.H., Chong, M.S.K. (2016). Surface Modification of Tissue Engineering Scaffolds. In: Gao, C. (eds) Polymeric Biomaterials for Tissue Regeneration. Springer, Singapore. https://doi.org/10.1007/978-981-10-2293-7_6

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