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Interaction of Dopamine and Glutamate Release in the Primate Prefrontal Cortex in Relation to Working Memory and Reward

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The Prefrontal Cortex as an Executive, Emotional, and Social Brain

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Abstract

The prefrontal cortex (PFC) aggregates information widely from other brain areas. The PFC plays the role of a command center that determines actions related to higher cognitive functions, such as working memory (WM), planning, decision-making, and behavioral inhibition, for the sake of better adaptation to the outside environment. Activities related to the higher cognitive function observed in the PFC are regulated by several neurotransmitters such as dopamine (DA), glutamate, serotonin, norepinephrine, and gamma-aminobutyric acid (GABA). Abnormalities of neurotransmitters, i.e., when these substances are out of the suitable range, impair the human cognitive performance and sometimes cause psychiatric disorders. While there are many reports about changes in neurotransmitters in the PFC of the human and rodent, there are very few studies on the PFC of the nonhuman primate. In this chapter, we discuss the function of the PFC in relation to changes in neurotransmitters, especially DA and glutamate, and their interactions, referring to our studies in which we investigated changes in neurotransmitters in the primate PFC in relation to cognitive task performance and reward.

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  1. Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan

    Tohru Kodama & Masataka Watanabe

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  1. Tohru Kodama
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Correspondence to Tohru Kodama .

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  1. Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Masataka Watanabe

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Kodama, T., Watanabe, M. (2017). Interaction of Dopamine and Glutamate Release in the Primate Prefrontal Cortex in Relation to Working Memory and Reward. In: Watanabe, M. (eds) The Prefrontal Cortex as an Executive, Emotional, and Social Brain. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56508-6_5

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