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B Cells

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Immunology of the Skin

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Abstract

The B cell is the central player of the humoral immune response by its capability to differentiate into an antibody-secreting plasma cell. Thus, B cells provide an essential component to defend the host from a variety of infections, and autoantibodies play significant roles in autoimmune diseases. In addition to antibody production, B cells are capable of influencing immune responses through several other mechanisms such as presenting antigens and providing costimulatory signals to T cells, regulating lymphoid tissue neogenesis and structure, and secreting cytokines. B cells are considered to be a promising therapeutic target in various diseases. This chapter describes B cell development, subset, and activation, as well as the role in the diseases and therapeutic manipulation.

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  1. Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Manabu Fujimoto

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  1. Department of Dermatology, Kyoto University Grad Sch of Med., Sakyo-ku, Kyoto, Japan

    Kenji Kabashima

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Fujimoto, M. (2016). B Cells. In: Kabashima, K. (eds) Immunology of the Skin. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55855-2_7

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