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Attention-Deficit/Hyperactivity Disorders

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Psychiatric Drugs in Children and Adolescents

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development, has persisted for at least 6 months to a degree that is inconsistent with expected developmental Ievels and that negatively impacts directly on social and academic/occupational activities. Manifestations of the disorder must be present in more than one setting (e.g., home, school, or work). Typically, symptoms vary depending on context within a given setting. According to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition DSM-5 criteria, several inattentive or hyperactive-impulsive symptoms must have been present prior to the age of 12 years.

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Literature

  • AACAP (Official Action (American Association of Child and Adolescent Psychiatry) (2007) Practise parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 46:894–921

    Article  Google Scholar 

  • Abikoff H, McGough J, Vitiello B, McCracken J, Davies M, Walkup J, Riddle M, Oatis M, Greenhill L, Skrobala A, March J, Gammon P, Robinson J, Lazell R, McMahon DJ, Ritz L; RUPP ADHD/Anxiety Study Group (2005) Sequential pharmacotherapy for children with comorbid attention-deficit/hyperactivity and anxiety disorders. J Am Acad Child Adolesc Psychiatry 44:418–427

    Article  Google Scholar 

  • Ahmann PA, Theye FW, Berg R, Linquist AJ, Van Erem AJ, Campbell LR (2001) Placebo-controlled evaluation of amphetamine mixture-dextroamphetamine salts and amphetamine salts (Adderall): efficacy rate and side effects. Pediatrics 107:e10

    Article  CAS  PubMed  Google Scholar 

  • Aman MG, Binder C, Turgay A (2004) Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol 14:243–254

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn (DSM-5TM). American Psychiatric Publishing, Washington/London

    Google Scholar 

  • Angold A, Costello EJ, Erkanli A (1999) Comorbidity. J Child Psychol Psychiatry 40:57–87

    Article  CAS  PubMed  Google Scholar 

  • Arnsten AF, Scahill L, Findling RL (2007) Alpha-2 adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data. J Child Adolesc Psychopharmacol 17:393–406

    Article  PubMed  Google Scholar 

  • Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, Danckaerts M, Döpfner M, Faraone SV, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke EJ, Taylor E (2006) Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline. Eur Child Adolesc Psychiatry 15:476–495

    Article  PubMed  Google Scholar 

  • Banaschewski T, Soutullo C, Lecendreux M, Johnson M, Zuddas A, Hodgkins P, Adeyi B, A Squires L, Coghill D (2013) Health-related quality of life and functional outcomes from a randomized, controlled study of lisdexamfetamine dimesylate in children and adolescents with attention deficit hyperactivity disorder. CNS Drugs 27:829–840

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Benjamin E, Salek S (2005) Stimulant-atypical antipsychotic interaction and acute dystonia. J Am Acad Child Adolesc Psychiatry 44:510–512

    Article  PubMed  Google Scholar 

  • Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA) (2011) Canadian ADHD practice guidelines, 3rd edn. CADDRA, Toronto

    Google Scholar 

  • Charach A, Dashti B, Carson P, Booker L, Lim CG, Lillie E, Yeung E, Ma J, Raina P, Schachar R (2011) Attention deficit hyperactivity disorder: effectiveness of treatment in at-risk preschoolers; long-term effectiveness in all ages; and variability in prevalence, diagnosis, and treatment. Agency for Healthcare Research and Quality (US), Rockville

    Google Scholar 

  • Coghill DR, Banaschewski T, Lecendreux M, Zuddas A, Dittmann RW, Otero IH, Civil R, Bloomfield R, Squires LA (2013) Efficacy of lisdexamfetamine dimesylate throughout the day in children and adolescents with attention-deficit/hyperactivity disorder: results from a randomized, controlled trial. Eur Child Adolesc Psychiatry (Epub ahead of print). May 25

    Google Scholar 

  • Cornforth C, Sonuga-Barke E, Coghill D (2010) Stimulant drug effects on attention deficit/hyperactivity disorder: a review of the effects of age and sex of patients. Curr Pharm Des 6:2424–2433

    Article  Google Scholar 

  • Cortese S, Holtmann M, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Dittmann RW, Graham J, Taylor E, Sergeant J (2013) Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry 54:227–246

    Article  PubMed  Google Scholar 

  • Czamara D, Tiesler CM, Kohlböck G, Berdel D, Hoffmann B, Bauer CP, Koletzko S, Schaaf B, Lehmann I, Herbarth O, von Berg A, Müller-Myhsok B, Schulte-Körne G, Heinrich J (2013) Children with ADHD symptoms have a higher risk for reading, spelling and math difficulties in the GINIplus and LISAplus cohort studies. PLoS One 8:e63859

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Eggers C, Rothenberger A, Berghaus U (1988) Clinical and neurobiological findings in children suffering from tic disease following treatment with tiapride. Eur Arch Psychiatry Clin N 237:223–229

    Article  CAS  Google Scholar 

  • Findling RL, Newcorn JH, Malone RP, Waheed A, Prince JB, Kratochvil CJ (2007) Pharmacotherapy of aggression in a 9-year-old with ADHD. J Am Acad Child Adolesc Psychiatry 46:653–658

    Article  PubMed  Google Scholar 

  • Geller D, Donnelly C, Lopez F, Rubin R, Newcorn J, Sutton V, Bakken R, Paczkowski M, Kelsey D, Sumner C (2007) Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder. J Am Acad Child Adolesc Psychiatry 46:1119–1127

    Article  PubMed  Google Scholar 

  • Greenhill L (2002) Stimulant medication treatment of children with attention deficit hyperactivity disorder. In: Jensen PS, Cooper JR (eds) Attention deficit hyperactivity disorder: state of the science. Best practices. Civic Research Institute, Kingston. pp. 919–927

    Google Scholar 

  • Greenhill L, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J et al, American Academy of Child and Adolescent Psychiatry (2002) Practice parameter for the use of stimulant medications in the treatment of children, adolescents and adults. J Am Acad Child Adolesc Psychiatry 41:26–49

    Google Scholar 

  • Greenhill L, Kollins S, Abikoff H, McCracken J, Riddle M, Swanson J, McGough J, Wigal S, Wigal T, Vitiello B, Skrobala A, Posner K, Ghuman J, Cunningham C, Davies M, Chuang S, Cooper T (2006) Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 45:1284–1293

    Article  PubMed  Google Scholar 

  • Groenman AP, Oosterlaan J, Rommelse N, Franke B, Roeyers H, Oades RD, Sergeant JA, Buitelaar JK, Faraone SV (2013) Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study. Addiction 108:1503–1511

    Article  PubMed  Google Scholar 

  • Handen BL, Feldman HM, Lurier A, Murray PJ (1999) Efficacy of methylphenidate among preschool children with developmental disabilities and ADHD. J Am Acad Child Adolesc Psychiatry 38:805–812

    Article  CAS  PubMed  Google Scholar 

  • Hosenbocus S, Chahal R (2009) A review of long-acting medications for ADHD in Canada. J Can Acad Child Adolesc Psychiatry 18:331–339

    PubMed Central  PubMed  Google Scholar 

  • Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schäfer H, Schmidtke A, Böning J, Lesch KP (2007) Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 257:309–317

    Article  PubMed  Google Scholar 

  • Jensen PS, Hinshaw SP, Kraemer HC, Lenora N, Newcorn JH, Abikoff HB, March JS, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B (2001) ADHD comorbidity findings from the MTA study: comparing co-morbid subgroups. J Am Acad Child Adolesc Psychiatry 40:147–158

    Article  CAS  PubMed  Google Scholar 

  • Koneski JA, Casella EB, Agertt F, Ferreira MG (2011) Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: a Brazilian sample study and literature review. Epilepsy Behav 21:228–232

    Article  PubMed  Google Scholar 

  • Kratochvil CJ, Vitiello B, Brent D, Bostic JQ, Naylor MW (2006) Selecting an antidepressant for the treatment of pediatric depression. J Am Acad Child Adolesc Psychiatry 45:371–373

    Article  PubMed  Google Scholar 

  • Levy F, Young D, Bennett KS, Martin NC, Hay DA (2013) Comorbid ADHD and mental health disorders: are these children more likely to develop reading disorders? Atten Defic Hyperact Disord 5:21–28

    Article  PubMed  Google Scholar 

  • Loy JH, Merry SN, Hetrick SE, Stasiak K (2012) Atypical antipsychotics for disruptive behaviour disorders in children and youths. Cochrane Database Syst Rev 9:CD008559

    Google Scholar 

  • Markowitz JS, Patrick KS (2001) Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder. Clin Pharmacokinet 40:753–771

    Article  CAS  PubMed  Google Scholar 

  • MTA Cooperation Group (1999a) Multimodal treatment Study of Children with ADHD. A 14 month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1073–1086

    Article  Google Scholar 

  • MTA Cooperation Group (1999b) Multimodal treatment Study of Children with ADHD. Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1088–1096

    Article  Google Scholar 

  • MTA Cooperation Group (2004) National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder. Pediatrics 113:754–761

    Article  Google Scholar 

  • National Institute for Health and Clinical Excellence (NICE) (2008) Attention deficit hyperactivity disorder – diagnosis and management of ADHD in children, young people and adults. National Clinical Practice Guideline Number 72. The British Psychological Society and The Royal College of Psychiatrists, London

    Google Scholar 

  • Pearson DA, Santos CW, Roache JD, Casat CD, Loveland KA, Lachar D, Lane DM, Faria LP, Cleveland LA (2003) Treatment effects of methylphenidate on behavioral adjustment in children with mental retardation and ADHD. J Am Acad Child Adolesc Psychiatry 42:209–216

    Article  PubMed  Google Scholar 

  • Pelham WE, Aronoff HR, Midlam JK, Shapiro CJ, Gnagy EM, Chronis AM, Onyango AN, Forehand G, Nguyen A, Waxmonsky J (1999) A comparison of Ritalin and Adderall: efficacy and time-course in children with attention-deficit/hyperactivity disorder. Pediatrics 103:e43

    Article  CAS  PubMed  Google Scholar 

  • Pliszka SR, Crismon ML, Hughes CW, Corners CK, Emslie GJ, Jensen PS, McCracken JT, Swanson JM, Lopez M (2006) Texas consensus conference panel on pharmacotherapy of childhood attention deficit hyperactivity disorder. The Texas Children’s Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45:642–657

    Article  PubMed  Google Scholar 

  • Popper CW (1995) Combining methylphenidate and clonidine – pharmacological questions an news reports about sudden-death. J Child Adolesc Psychopharmacol 5:157–166

    Article  Google Scholar 

  • Sallee F, Connor DF, Newcorn JH (2013) A review of the rationale and clinical utilization of α2-adrenoceptor agonists for the treatment of attention-deficit/hyperactivity and related disorders. J Child Adolesc Psychopharmacol 23:308–319

    Article  CAS  PubMed  Google Scholar 

  • Santosh PJ, Taylor E (2000) Stimulant drugs. Eur Child Adolesc Psychiatry 9(Suppl 1):127–143

    Google Scholar 

  • Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF (2001) A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 158:1067–1074

    Article  CAS  PubMed  Google Scholar 

  • Simonoff E, Taylor E, Baird G, Bernard S, Chadwick O, Liang H, Whitwell S, Riemer K, Sharma K, Sharma SP, Wood N, Kelly J, Golaszewski A, Kennedy J, Rodney L, West N, Walwyn R, Jichi F (2013) Randomized controlled double-blind trial of optimal dose methylphenidate in children and adolescents with severe attention deficit hyperactivity disorder and intellectual disability. J Child Psychol Psychiatry 54:527–535

    Article  PubMed  Google Scholar 

  • Sinzig J, Döpfner M, Lehmkuhl G, German Methylphenidate Study Group, Uebel H, Schmeck K, Poustka F, Gerber WD, Günter M, Knölker U, Gehrke M, Hässler F, Resch F, Brünger M, Ose C, Fischer R (2007) Long-acting methylphenidate has an effect on aggressive behavior in children with attention-deficit/hyperactivity disorder. J Child Adol Psychop 4:421–432

    Google Scholar 

  • Sonuga-Barke EJS, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, Stevenson J, Danckaerts M, van der Oord S, Döpfner M, Dittmann RW, Simonoff E, Zuddas A, Banaschewski T, Buitelaar J, Coghill D, Hollis C, Konofal E, Lecendreux M, Wong ICK, Sergeant J, European ADHD Guidelines Group (2013) Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiat 170:275–289

    Google Scholar 

  • Spencer TJ, Abikoff HB, Connor DF, Biederman J, Pliszka SR, Boellner S, Read SC, Pratt R (2006) Efficacy and safety of mixed amphetamine salts extended release (adderall XR) in the management of oppositional defiant disorder with or without comorbid attention-deficit/hyperactivity disorder in school-aged children and adolescents: a 4-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled, forced-dose-escalation study. Clin Ther 28:402–418

    Article  CAS  PubMed  Google Scholar 

  • Svanborg P, Thernlund G, Gustafsson PA, Hägglöf B, Schacht A, Kadesjö B (2009) Atomoxetine improves patient and family co** in attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in Swedish children and adolescents. Eur Child Adolesc Psychiatry 18:725–735

    Article  PubMed Central  PubMed  Google Scholar 

  • Swanson JM, Kraemer HC, Hinshaw SP, Arnold LE, Conners CK, Abikoff HB, Clevenger B, Davies M, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Owens EB, Pelham WE, Schiller E, Severe JB, Simpson S, Vitiello B, Wells K, Wigal T, Wu M (2001) Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psychiatry 40:168–179

    Article  CAS  PubMed  Google Scholar 

  • Taurines R, Schmitt J, Renner T, Conner AC, Warnke A, Romanos M (2010) Developmental comorbidity in attention-deficit/hyperactivity disorder. Atten Defic Hyperact Disord 2:276–289

    Article  Google Scholar 

  • Taylor E, Döpfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Rothenberger A, Sonuga-Barke E, Steinhausen HC, Zuddas A (2004) European clinical guidelines for hyperkinetic disorder-first upgrade. Eur Child Adolesc Psychiatry 13(Suppl 1):17–30

    Google Scholar 

  • Weisman H, Qureshi IA, Leckman JF, Scahill L, Bloch MH (2013) Systematic review: pharmacological treatment of tic disorders – efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neurosci Biobehav Rev 37:1162–1171

    Article  CAS  PubMed  Google Scholar 

  • Wilens TE, McBurnett K, Bukstein O, McGough J, Greenhill L, Lerner M, Stein MA, Conners CK, Duby J, Newcorn J, Bailey CE, Kratochvil CJ, Coury D, Casat C, Denisco MJ, Halstead P, Bloom L, Zimmerman BA, Gu J, Cooper KM, Lynch JM (2006) Multisite controlled study of OROS methylphenidate in the treatment of adolescents with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med 160:82–90

    Article  PubMed  Google Scholar 

  • Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, Utzinger L, Fusillo S (2008) Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry 47:21–31

    Article  PubMed  Google Scholar 

  • World Health Organization (1996) Multiaxial classification of child and adolescent psychiatric disorders. The ICD-10 classification of mental and behavioral disorders in children and adolescents. Cambridge University Press, Cambridge

    Book  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, University of Zurich, Neumuensterallee 9, 1482, 8032, Zurich, Switzerland

    Susanne Walitza MD

  2. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstr.15, 97080, Würzburg, Germany

    Marcel Romanos MD

  3. NYS Psychiatric Institute, New York Presbyterian Hospital, Riverside Drive 1051, New York, NY, 10032, USA

    Laurence Greenhill MD

  4. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Mannheim, J5, 68159, Mannheim, Germany

    Tobias Banaschewski MD

Authors
  1. Susanne Walitza MD
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  2. Marcel Romanos MD
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  3. Laurence Greenhill MD
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  4. Tobias Banaschewski MD
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Corresponding author

Correspondence to Susanne Walitza MD .

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Editors and Affiliations

  1. Kinder- und Jugendpsychiatrie, Universitätsklinikum Würzburg Klinik und Poliklinik, Würzburg, Germany

    Manfred Gerlach

  2. Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Würzburg Klinik und Poliklinik für Kinder- und, Würzburg, Germany

    Andreas Warnke

  3. Child and Adolescent Psychiatry New York Presbyterian Hospital, New York, New York, USA

    Laurence Greenhill

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Walitza, S., Romanos, M., Greenhill, L., Banaschewski, T. (2014). Attention-Deficit/Hyperactivity Disorders. In: Gerlach, M., Warnke, A., Greenhill, L. (eds) Psychiatric Drugs in Children and Adolescents. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1501-5_12

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