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Dendritische Zellen und Hormone

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Reproduktionsimmunologie

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Zusammenfassung

Hauptunterschied der Plazentation beim Menschen im Vergleich zu den meisten Nichtprimaten ist, dass es nicht nur zu einem bloßen oberflächlichen Kontakt plazentarer Zellen mit dem mütterlichen Endometrium, sondern zu einer tiefen Invasion fetaler Trophoblastzellen in den mütterlichen Uterus kommt (Loke et al. 1995). Um diesen Invasionsprozess zu ermöglichen, ist eine Transformation des Endometriums in die glykogenreiche Dezidua notwendig, ein Prozess, der durch den Anstieg der Steroidhormone gesteuert wird. Neben diesen morphologischen Veränderungen kommt es in der Dezidua der Frühschwangerschaft zu einem deutlichen Anstieg von lokalen Leukozytenpopulationen

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Literatur

  • Audiger C, Rahman MJ, Yun TJ, Tarbell KV, Lesage S (2017) The importance of dendritic cells in maintaining immune tolerance. J Immunol 198(6):2223–2231

    Google Scholar 

  • Bachmann MF, Kopf M (2002) Balancing protective immunity and immunopathology. Curr Opin Immunol 14(4):413–419

    Article  CAS  PubMed  Google Scholar 

  • Butts CL, Shukair SA, Duncan KM, Bowers E, Horn C, Belyavskaya E et al (2007) Progesterone inhibits mature rat dendritic cells in a receptor-mediated fashion. Int Immunol 19(3):287–296

    Article  CAS  PubMed  Google Scholar 

  • Florio P, Severi FM, Bocchi C, Luisi S, Mazzini M, Danero S et al (2007) Single serum activin a testing to predict ectopic pregnancy. J Clin Endocrinol Metab 92(5):1748–1753

    Article  CAS  PubMed  Google Scholar 

  • Gellersen B, Brosens JJ (2014) Cyclic decidualization of the human endometrium in reproductive health and failure. Endocr Rev er20141045

    Google Scholar 

  • Guerin LR, Prins JR, Robertson SA (2009) Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 15(5):517–535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Iberg CA, Jones A, Hawiger D (2017) Dendritic cells as inducers of peripheral tolerance. Trends Immunol 38(11):793–804

    Google Scholar 

  • Kammerer U, Eggert AO, Kapp M, McLellan AD, Geijtenbeek TB, Dietl J et al (2003) Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. Am J Pathol 162(3):887–896

    Article  PubMed  PubMed Central  Google Scholar 

  • Kayisli UA, Mahutte NG, Arici A (2002) Uterine chemokines in reproductive physiology and pathology. Am J Reprod Immunol 47(4):213–221

    Article  PubMed  Google Scholar 

  • Li G, Abediankenari S, Kim YJ, Campbell TB, Ito S, Graham-Evans B et al (2007) TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors. Blood 110(8):2872–2879

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Loke YW, King A, Burrows TD (1995) Decidua in human implantation. Hum Reprod 10 Suppl 2:14–21.

    Google Scholar 

  • Marjono AB, Brown DA, Horton KE, Wallace EM, Breit SN, Manuelpillai U (2003) Macrophage inhibitory cytokine-1 in gestational tissues and maternal serum in normal and pre-eclamptic pregnancy. Placenta 24(1):100–106

    Article  CAS  PubMed  Google Scholar 

  • Moore AG, Brown DA, Fairlie WD, Bauskin AR, Brown PK, Munier ML et al (2000) The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J Clin Endocrinol Metab 85(12):4781–4788

    CAS  PubMed  Google Scholar 

  • Muttukrishna S, Jauniaux E, Greenwold N, McGarrigle H, Jivraj S, Carter S et al (2002) Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages. Hum Reprod 17(12):3072–3078

    Article  CAS  PubMed  Google Scholar 

  • Sallusto F, Lanzavecchia A (1999) Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J Exp Med 189(4):611–614

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schuurhuis DH, Fu N, Ossendorp F, Melief CJ (2006) Ins and outs of dendritic cells. Int Arch Allergy Immunol 140(1):53–72

    Article  PubMed  Google Scholar 

  • Segerer SE, Muller N, Brandt J, Kapp M, Dietl J, Reichardt HM et al (2008) The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation. Reprod Biol Endocrinol 6:17

    Article  PubMed  PubMed Central  Google Scholar 

  • Segerer SE, Muller N, van den Brandt J, Kapp M, Dietl J, Reichardt HM et al (2009) Impact of female sex hormones on the maturation and function of human dendritic cells. Am J Reprod Immunol 62(3):165–173

    Article  CAS  PubMed  Google Scholar 

  • Segerer SE, Rieger L, Kapp M, Dombrowski Y, Muller N, Dietl J et al (2012) MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts. Hum Reprod 27(1):200–209

    Article  CAS  PubMed  Google Scholar 

  • Soldin OP, Guo T, Weiderpass E, Tractenberg RE, Hilakivi-Clarke L, Soldin SJ (2005) Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril 84(3):701–710

    Google Scholar 

  • Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159(10):4772–4780

    Article  CAS  PubMed  Google Scholar 

  • Steinman RM, Hemmi H (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17–58

    CAS  PubMed  Google Scholar 

  • Tong S, Marjono B, Brown DA, Mulvey S, Breit SN, Manuelpillai U et al (2004) Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage. Lancet 363(9403):129–130

    Article  CAS  PubMed  Google Scholar 

  • Waisman A, Lukas D, Clausen BE, Yogev N (2017) Dendritic cells as gatekeepers of tolerance. Semin Immunopathol 39(2):153–163

    Article  CAS  PubMed  Google Scholar 

  • Wan H, Versnel MA, Leijten LM, van Helden-Meeuwsen CG, Fekkes D, Leenen PJ et al (2008) Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype. J Leukoc Biol 83(4):894–901

    Article  CAS  PubMed  Google Scholar 

  • **a CQ, Peng R, Beato F, Clare-Salzler MJ (2005) Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity. Scand J Immunol 62(1):45–54

    Google Scholar 

  • Yang L, Hu Y, Li X, Zhao J, Hou Y (2006) Prolactin modulates the functions of murine spleen CD11c-positive dendritic cells. Int Immunopharmacol 6(9):1478–1486

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch, pränatale Medizin, Endokrinologie und Osteologie, amedes MVZ Hamburg, Hamburg, Deutschland

    Sabine Segerer

  2. Frauenklinik und Poliklinik, Universitätsklinikum Würzburg, Würzburg, Deutschland

    Ulrike Kämmerer

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  1. Sabine Segerer
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  2. Ulrike Kämmerer
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Correspondence to Sabine Segerer .

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Editors and Affiliations

  1. Gynäkologische Endokrinologie und Sterilitätsmedizin, Kinderwunsch Centrum München MZV, München, Deutschland

    Wolfgang Würfel

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© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

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Segerer, S., Kämmerer, U. (2023). Dendritische Zellen und Hormone. In: Würfel, W. (eds) Reproduktionsimmunologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63907-8_4

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  • DOI: https://doi.org/10.1007/978-3-662-63907-8_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-63906-1

  • Online ISBN: 978-3-662-63907-8

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