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Lung Transplantation-Related Pathology

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Pathology of Lung Disease

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Abstract

Lung transplantation-related pathology includes a large box of disorders such as (a) explant pathology, (b) perioperative allograft pathology, (d) rejection (acute and chronic), (e) infections, and (f) tumors.

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References

  1. Calabrese F, Lunardi F, Nannini N. In: Caenazzo L, editor. The role of biobanking in rare diseases. New insights on biobanks. Padova: CLEUP; 2013. p. 67.

    Google Scholar 

  2. Stewart S, McNeil K, Nashef SA, Wells FC, Higenbottam TW, Wallwork J. Audit of referral and explant diagnoses in lung transplantation: a pathologic study of lungs removed for parenchymal disease. J Heart Lung Transplant. 1995;14:1173–86.

    CAS  PubMed  Google Scholar 

  3. Calabrese F, Alessandrini L, Loy M, Marulli G, Balestro E, Perissinotto E, Valente M, Rea F. Comparison between referral diagnosis of patients requiring transplantation and pathologic diagnosis of native lungs. J Heart Lung Transplant. 2009;28:1135–40.

    Article  PubMed  Google Scholar 

  4. Travis WD, Costabel U, Hansell DM, King Jr TE, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU, Behr J, Bouros D, Brown KK, Colby TV, Collard HR, Cordeiro CR, Cottin V, Crestani B, Drent M, Dudden RF, Egan J, Flaherty K, Hogaboam C, Inoue Y, Johkoh T, Kim DS, Kitaichi M, Loyd J, Martinez FJ, Myers J, Protzko S, Raghu G, Richeldi L, Sverzellati N, Swigris J, Valeyre D. ATS/ERS committee on idiopathic interstitial pneumonias: an official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188:733–48.

    Article  PubMed  Google Scholar 

  5. Rommens JM, Iannuzzi MC, Kerem B, Drumm ML, Melmer G, Dean M, Rozmahel R, Cole JL, Kennedy D, Hidaka N. Identification of the cystic fibrosis gene: chromosome walking and jum**. Science. 1989;245:1059–65.

    Article  CAS  PubMed  Google Scholar 

  6. Grubb BR, Boucher RC. Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev. 1999;79:S193–214.

    CAS  PubMed  Google Scholar 

  7. Stoltz DA, Meyerholz DK, Welsh MJ. Origins of cystic fibrosis lung disease. N Engl J Med. 2015;372:351–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Tomashefski Jr JF, Bruce M, Stern RC, Dearborn DG, Dahms B. Pulmonary air cysts in cystic fibrosis: relation of pathologic features to radiologic findings and history of pneumothorax. Hum Pathol. 1985;16:253–61.

    Article  PubMed  Google Scholar 

  9. Tomashefski Jr JF, Bruce M, Goldberg HI, Dearborn DG. Regional distribution of macroscopic lung disease in cystic fibrosis. Am Rev Respir Dis. 1986;133:535–40.

    PubMed  Google Scholar 

  10. Mets OM, Roothaan SM, Bronsveld I, Luijk B, van de Graaf EA, Vink A, de Jong PA. Emphysema is common in lungs of cystic fibrosis lung transplantation patients: a histopathological and computed tomography study. PLoS One. 2015;10:e0128062.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 2009;360:2445–54.

    Article  CAS  PubMed  Google Scholar 

  12. Calabrese F, Giacometti C, Beghe B, Rea F, Loy M, Zuin R, Marulli G, Baraldo S, Saetta M, Valente M. Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema. Respir Res. 2005;6:14.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, Turato G, Lokar-Oliani K, Papi A, Zuin R, Sfriso P, Balestro E, Dinarello CA, Saetta M. IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178:894–901.

    Article  CAS  PubMed  Google Scholar 

  14. Polverino F, Baraldo S, Bazzan E, Agostini S, Turato G, Lunardi F, Balestro E, Damin M, Papi A, Maestrelli P, Calabrese F, Saetta M. A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family. Am J Respir Crit Care Med. 2010;182:1011–9.

    Article  PubMed  Google Scholar 

  15. Baraldo S, Turato G, Lunardi F, Bazzan E, Schiavon M, Ferrarotti I, Molena B, Cazzuffi R, Damin M, Balestro E, Luisetti M, Rea F, Calabrese F, Cosio MG, Saetta M. Immune activation in alpha1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm. Am J Respir Crit Care Med. 2015;191:402–9.

    Article  CAS  PubMed  Google Scholar 

  16. King Jr TE, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011;378:1949–61.

    Article  PubMed  Google Scholar 

  17. Hodgson U, Laitinen T, Tukiainen P. Nationwide prevalence of sporadic and familial idiopathic pulmonary fibrosis: evidence of founder effect among multiplex families in Finland. Thorax. 2002;57:338–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J, Tata LJ. Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax. 2006;61:980–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King Jr TE, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ. ATS/ERS/JRS/ALAT committee on idiopathic pulmonary fibrosis: an official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788–824.

    Article  PubMed  Google Scholar 

  20. Selman M, Pardo A, Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med. 2008;5:e62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Calabrese F, Giacometti C, Rea F, Loy M, Valente M. Idiopathic interstitial pneumonias: primum movens: epithelial, endothelial or whatever. Sarcoidosis Vasc Diffuse Lung Dis. 2005;22 Suppl 1:S15–23.

    PubMed  Google Scholar 

  22. Calabrese F, Lunardi F, Balestro E, Marulli G, Perissinotto E, Loy M, Nannini N, Valente M, Saetta M, Agostini C, Rea F. Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis. Pathology. 2012;44:192–8.

    Article  CAS  PubMed  Google Scholar 

  23. Meyer EC, Liebow AA. Relationship of interstitial pneumonia honeycombing and atypical epithelial proliferation to cancer of the lung. Cancer. 1965;18:322–51.

    Article  CAS  PubMed  Google Scholar 

  24. Kato H. Expression and function of squamous cell carcinoma antigen. Anticancer Res. 1996;16:2149–53.

    CAS  PubMed  Google Scholar 

  25. Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci U S A. 1998;95:11891–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Hironaka M, Fukayama M. Pulmonary fibrosis and lung carcinoma: a comparative study of metaplastic epithelia in honeycombed areas of usual interstitial pneumonia with or without lung carcinoma. Pathol Int. 1999;49:1060–6.

    Article  CAS  PubMed  Google Scholar 

  27. Kawasaki H, Ogura T, Yokose T, Nagai K, Nishiwaki Y, Esumi H. P53 gene alteration in atypical epithelial lesions and carcinoma in patients with idiopathic pulmonary fibrosis. Hum Pathol. 2001;32:1043–9.

    Article  CAS  PubMed  Google Scholar 

  28. Aubry MC, Myers JL, Douglas WW, Tazelaar HD, Washington Stephens TL, Hartman TE, Deschamps C, Pankratz VS. Primary pulmonary carcinoma in patients with idiopathic pulmonary fibrosis. Mayo Clin Proc. 2002;77:763–70.

    Article  PubMed  Google Scholar 

  29. Murata K, Ota S, Niki T, Goto A, Li CP, Ruriko UM, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M. p63 - key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis. Exp Mol Pathol. 2007;83:367–76.

    Article  CAS  PubMed  Google Scholar 

  30. Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M. AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer. Pathol Res Pract. 2008;204:295–304.

    Article  PubMed  Google Scholar 

  31. Zhou Q, Salvesen GS. Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. Biochem J. 1997;324(Pt 2):361–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Bromme D, Chapman HA, Silverman GA. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry. 1998;37:5258–66.

    Article  CAS  PubMed  Google Scholar 

  33. Yamazaki T, Aoki Y. Cathepsin G enhances human natural killer cytotoxicity. Immunology. 1998;93:115–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Cataltepe S, Gornstein ER, Schick C, Kamachi Y, Chatson K, Fries J, Silverman GA, Upton MP. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem. 2000;48:113–22.

    Article  CAS  PubMed  Google Scholar 

  35. Stenman J, Hedstrom J, Grenman R, Leivo I, Finne P, Palotie A, Orpana A. Relative levels of SCCA2 and SCCA1 mRNA in primary tumors predicts recurrent disease in squamous cell cancer of the head and neck. Int J Cancer. 2001;95:39–43.

    Article  CAS  PubMed  Google Scholar 

  36. McGettrick AF, Barnes RC, Worrall DM. SCCA2 inhibits TNF-mediated apoptosis in transfected HeLa cells. The reactive centre loop sequence is essential for this function and TNF-induced cathepsin G is a candidate target. Eur J Biochem. 2001;268:5868–75.

    Article  CAS  PubMed  Google Scholar 

  37. Biggs JR, Yang J, Gullberg U, Muchardt C, Yaniv M, Kraft AS. The human brm protein is cleaved during apoptosis: the role of cathepsin G. Proc Natl Acad Sci U S A. 2001;98:3814–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hsu KF, Huang SC, Shiau AL, Cheng YM, Shen MR, Chen YF, Lin CY, Lee BH, Chou CY. Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer. Int J Gynecol Cancer. 2007;17:174–81.

    Article  PubMed  Google Scholar 

  39. Calabrese F, Lunardi F, Giacometti C, Marulli G, Gnoato M, Pontisso P, Saetta M, Valente M, Rea F, Perissinotto E, Agostini C. Overexpression of squamous cell carcinoma antigen in idiopathic pulmonary fibrosis: clinicopathological correlations. Thorax. 2008;63:795–802.

    Article  CAS  PubMed  Google Scholar 

  40. Lunardi F, Villano G, Perissinotto E, Agostini C, Rea F, Gnoato M, Bradaschia A, Valente M, Pontisso P, Calabrese F. Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice. Lab Invest. 2011;91:945–54.

    Article  CAS  PubMed  Google Scholar 

  41. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009;19:156–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, Cannito S, Fassina G, Parola M, Gatta A, Pontisso P. SERPINB3 induces epithelial-mesenchymal transition. J Pathol. 2010;221:343–56.

    Article  CAS  PubMed  Google Scholar 

  43. Calabrese F, Kipar A, Lunardi F, Balestro E, Perissinotto E, Rossi E, Nannini N, Marulli G, Stewart JP, Rea F. Herpes virus infection is associated with vascular remodeling and pulmonary hypertension in idiopathic pulmonary fibrosis. PLoS One. 2013;8:e55715.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Egan JJ, Stewart JP, Hasleton PS, Arrand JR, Carroll KB, Woodcock AA. Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis. Thorax. 1995;50:1234–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Kuwano K, Nomoto Y, Kunitake R, Hagimoto N, Matsuba T, Nakanishi Y, Hara N. Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction. Eur Respir J. 1997;10:1445–9.

    Article  CAS  PubMed  Google Scholar 

  46. Stewart JP, Egan JJ, Ross AJ, Kelly BG, Lok SS, Hasleton PS, Woodcock AA. The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1999;159:1336–41.

    Article  CAS  PubMed  Google Scholar 

  47. Kelly BG, Lok SS, Hasleton PS, Egan JJ, Stewart JP. A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2002;166:510–3.

    Article  PubMed  Google Scholar 

  48. Lok SS, Haider Y, Howell D, Stewart JP, Hasleton PS, Egan JJ. Murine gammaherpesvirus as a cofactor in the development of pulmonary fibrosis in bleomycin resistant mice. Eur Respir J. 2002;20:1228–32.

    Article  CAS  PubMed  Google Scholar 

  49. Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, Graham BS, Brigham KL, Oates Jr JA, Loyd JE, Stecenko AA. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J Clin Microbiol. 2003;41:2633–40.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Zamo A, Poletti V, Reghellin D, Montagna L, Pedron S, Piccoli P, Chilosi M. HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005;22:123–8.

    PubMed  Google Scholar 

  51. Mora AL, Woods CR, Garcia A, Xu J, Rojas M, Speck SH, Roman J, Brigham KL, Stecenko AA. Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. Am J Physiol Lung Cell Mol Physiol. 2005;289:L711–21.

    Article  CAS  PubMed  Google Scholar 

  52. Mora AL, Torres-Gonzalez E, Rojas M, Xu J, Ritzenthaler J, Speck SH, Roman J, Brigham K, Stecenko A. Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. Am J Respir Crit Care Med. 2007;175:1139–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. McMillan TR, Moore BB, Weinberg JB, Vannella KM, Fields WB, Christensen PJ, van Dyk LF, Toews GB. Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. Am J Respir Crit Care Med. 2008;177:771–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Arase Y, Suzuki F, Suzuki Y, Akuta N, Kobayashi M, Kawamura Y, Yatsuji H, Sezaki H, Hosaka T, Hirakawa M, Saito S, Ikeda K, Kumada H. Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis. World J Gastroenterol. 2008;14:5880–6.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Malizia AP, Keating DT, Smith SM, Walls D, Doran PP, Egan JJ. Alveolar epithelial cell injury with Epstein-Barr virus upregulates TGFbeta1 expression. Am J Physiol Lung Cell Mol Physiol. 2008;295:L451–60.

    Article  CAS  PubMed  Google Scholar 

  56. Malizia AP, Lacey N, Walls D, Egan JJ, Doran PP. CUX1/Wnt signaling regulates epithelial mesenchymal transition in EBV infected epithelial cells. Exp Cell Res. 2009;315:1819–31.

    Article  CAS  PubMed  Google Scholar 

  57. Malizia AP, Egan JJ, Doran PP. IL-4 increases CD21-dependent infection of pulmonary alveolar epithelial type II cells by EBV. Mol Immunol. 2009;46:1905–10.

    Article  CAS  PubMed  Google Scholar 

  58. Pozharskaya V, Torres-Gonzalez E, Rojas M, Gal A, Amin M, Dollard S, Roman J, Stecenko AA, Mora AL. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS One. 2009;4:e7559.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. Pulkkinen V, Salmenkivi K, Kinnula VL, Sutinen E, Halme M, Hodgson U, Lehto J, Jaaskelainen A, Piiparinen H, Kere J, Lautenschlager I, Lappalainen M, Myllarniemi M. A novel screening method detects herpesviral DNA in the idiopathic pulmonary fibrosis lung. Ann Med. 2012;44:178–86.

    Article  CAS  PubMed  Google Scholar 

  60. Vannella KM, Luckhardt TR, Wilke CA, van Dyk LF, Toews GB, Moore BB. Latent herpesvirus infection augments experimental pulmonary fibrosis. Am J Respir Crit Care Med. 2010;181:465–77.

    Article  CAS  PubMed  Google Scholar 

  61. Sides MD, Klingsberg RC, Shan B, Gordon KA, Nguyen HT, Lin Z, Takahashi T, Flemington EK, Lasky JA. The Epstein-Barr virus latent membrane protein 1 and transforming growth factor-beta1 synergistically induce epithelial-mesenchymal transition in lung epithelial cells. Am J Respir Cell Mol Biol. 2011;44:852–62.

    Article  CAS  PubMed  Google Scholar 

  62. Egan JJ, Adamali HI, Lok SS, Stewart JP, Woodcock AA. Ganciclovir antiviral therapy in advanced idiopathic pulmonary fibrosis: an open pilot study. Pulm Med. 2011;2011:240805.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Tuder RM, Lee SD, Cool CC. Histopathology of pulmonary hypertension. Chest. 1998;114:1S–6.

    Article  CAS  PubMed  Google Scholar 

  64. Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation. 2002;105:1672–8.

    Article  CAS  PubMed  Google Scholar 

  65. Rabinovitch M. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest. 2012;122:4306–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Schiavon M, Fadini GP, Lunardi F, Agostini C, Boscaro E, Calabrese F, Marulli G, Rea F. Increased tissue endothelial progenitor cells in end-stage lung diseases with pulmonary hypertension. J Heart Lung Transplant. 2012;31:1025–30.

    Article  PubMed  Google Scholar 

  67. Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb SB, Levvey BJ, Lund LH, Meiser B, Rossano JW, Stehlik J. The Registry of the International Society for heart and lung transplantation: thirty-second official adult lung and heart-lung transplantation report–2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34(10):1264–77.

    Google Scholar 

  68. Stewart S, Fishbein MC, Snell GI, Berry GJ, Boehler A, Burke MM, Glanville A, Gould FK, Magro C, Marboe CC, McNeil KD, Reed EF, Reinsmoen NL, Scott JP, Studer SM, Tazelaar HD, Wallwork JL, Westall G, Zamora MR, Zeevi A, Yousem SA. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant. 2007;26:1229–42.

    Article  PubMed  Google Scholar 

  69. Masson E, Stern M, Chabod J, Thevenin C, Gonin F, Rebibou JM, Tiberghien P. Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies. J Heart Lung Transplant. 2007;26:642–5.

    Article  PubMed  Google Scholar 

  70. Dawson KL, Parulekar A, Seethamraju H. Treatment of hyperacute antibody-mediated lung allograft rejection with eculizumab. J Heart Lung Transplant. 2012;31:1325–6.

    Article  PubMed  Google Scholar 

  71. Estenne M, Maurer JR, Boehler A, Egan JJ, Frost A, Hertz M, Mallory GB, Snell GI, Yousem S. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21:297–310.

    Article  PubMed  Google Scholar 

  72. Berry G, Burke M, Andersen C, Angelini A, Bruneval P, Calabrese F, Fishbein MC, Goddard M, Leone O, Maleszewski J, Marboe C, Miller D, Neil D, Padera R, Rassl D, Revello M, Rice A, Stewart S, Yousem SA. Pathology of pulmonary antibody-mediated rejection: 2012 update from the pathology council of the ISHLT. J Heart Lung Transplant. 2013;32:14–21.

    Article  PubMed  Google Scholar 

  73. Sato M, Waddell TK, Wagnetz U, Roberts HC, Hwang DM, Haroon A, Wagnetz D, Chaparro C, Singer LG, Hutcheon MA, Keshavjee S. Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction. J Heart Lung Transplant. 2011;30:735–42.

    Article  PubMed  Google Scholar 

  74. Verleden GM, Vos R, Verleden SE, De Wever W, De Vleeschauwer SI, Willems-Widyastuti A, Scheers H, Dupont LJ, Van Raemdonck DE, Vanaudenaerde BM. Survival determinants in lung transplant patients with chronic allograft dysfunction. Transplantation. 2011;92:703–8.

    Article  PubMed  Google Scholar 

  75. Frankel SK, Cool CD, Lynch DA, Brown KK. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest. 2004;126:2007–13.

    Article  PubMed  Google Scholar 

  76. Ofek E, Sato M, Saito T, Wagnetz U, Roberts HC, Chaparro C, Waddell TK, Singer LG, Hutcheon MA, Keshavjee S, Hwang DM. Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis. Mod Pathol. 2013;26:350–6.

    Article  CAS  PubMed  Google Scholar 

  77. von der Thusen JH, Hansell DM, Tominaga M, Veys PA, Ashworth MT, Owens CM, Nicholson AG. Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation. Mod Pathol. 2011;24:1633–9.

    Article  PubMed  Google Scholar 

  78. Reddy TL, Tominaga M, Hansell DM, von der Thusen J, Rassl D, Parfrey H, Guy S, Twentyman O, Rice A, Maher TM, Renzoni EA, Wells AU, Nicholson AG. Pleuroparenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur Respir J. 2012;40:377–85.

    Article  PubMed  Google Scholar 

  79. Valantine HA, Luikart H, Doyle R, Theodore J, Hunt S, Oyer P, Robbins R, Berry G, Reitz B. Impact of cytomegalovirus hyperimmune globulin on outcome after cardiothoracic transplantation: a comparative study of combined prophylaxis with CMV hyperimmune globulin plus ganciclovir versus ganciclovir alone. Transplantation. 2001;72:1647–52.

    Article  CAS  PubMed  Google Scholar 

  80. Weill D, Lock BJ, Wewers DL, Young KR, Zorn GL, Early L, Kirklin JK, McGiffin DC. Combination prophylaxis with ganciclovir and cytomegalovirus (CMV) immune globulin after lung transplantation: effective CMV prevention following daclizumab induction. Am J Transplant. 2003;3:492–6.

    Article  CAS  PubMed  Google Scholar 

  81. Palmer SM, Limaye AP, Banks M, Gallup D, Chapman J, Lawrence EC, Dunitz J, Milstone A, Reynolds J, Yung GL, Chan KM, Aris R, Garrity E, Valentine V, McCall J, Chow SC, Davis RD, Avery R. Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial. Ann Intern Med. 2010;152:761–9.

    Article  PubMed  Google Scholar 

  82. Arbustini E, Grasso M, Diegoli M, Percivalle E, Grossi P, Bramerio M, Campana C, Goggi C, Gavazzi A, Vigano M. Histopathologic and molecular profile of human cytomegalovirus infections in patients with heart transplants. Am J Clin Pathol. 1992;98:205–13.

    Article  CAS  PubMed  Google Scholar 

  83. Lu DY, Qian J, Easley KA, Waldrop SM, Cohen C. Automated in situ hybridization and immunohistochemistry for cytomegalovirus detection in paraffin-embedded tissue sections. Appl Immunohistochem Mol Morphol. 2009;17:158–64.

    Article  CAS  PubMed  Google Scholar 

  84. Riise GC, Andersson R, Bergstrom T, Lundmark A, Nilsson FN, Olofsson S. Quantification of cytomegalovirus DNA in BAL fluid: a longitudinal study in lung transplant recipients. Chest. 2000;118:1653–60.

    Article  CAS  PubMed  Google Scholar 

  85. Westall GP, Michaelides A, Williams TJ, Snell GI, Kotsimbos TC. Human cytomegalovirus load in plasma and bronchoalveolar lavage fluid: a longitudinal study of lung transplant recipients. J Infect Dis. 2004;190:1076–83.

    Article  PubMed  Google Scholar 

  86. Calabrese F, Lunardi F, Popper H. Molecular diagnosis in lung diseases. Front Biosci (Landmark Ed). 2015;20:644–88.

    Article  Google Scholar 

  87. You XM, Steinmuller C, Wagner TO, Bruggeman CA, Haverich A, Steinhoff G. Enhancement of cytomegalovirus infection and acute rejection after allogeneic lung transplantation in the rat: virus-induced expression of major histocompatibility complex class II antigens. J Heart Lung Transplant. 1996;15:1108–19.

    CAS  PubMed  Google Scholar 

  88. Halenius A, Gerke C, Hengel H. Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets-but how many arrows in the quiver? Cell Mol Immunol. 2015;12:139–53.

    Article  CAS  PubMed  Google Scholar 

  89. Penn I. Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl. 1998;12:147–58.

    Google Scholar 

  90. Gutierrez-Dalmau A, Campistol JM. Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review. Drugs. 2007;67:1167–98.

    Article  CAS  PubMed  Google Scholar 

  91. Calabrese F, Loy M, Lunardi F, Marino D, Aversa SM, Rea F. Acute cellular rejection and Epstein-Barr virus-related post-transplant lymphoproliferative disorder in a pediatric lung transplant with low viral load. Transpl Infect Dis. 2010;12:342–6.

    Article  CAS  PubMed  Google Scholar 

  92. Glotz D, Chapman JR, Dharnidharka VR, Hanto DW, Castro MC, Hirsch HH, Leblond V, Mehta AK, Moulin B, Pagliuca A, Pascual J, Rickinson AB, Russo FP, Trappe RU, Webster AC, Zuckermann AO, Gross TG. The Seville expert workshop for progress in posttransplant lymphoproliferative disorders. Transplantation. 2012;94:784–93.

    Article  PubMed  Google Scholar 

  93. Paya CV. Indirect effects of CMV in the solid organ transplant patient. Transpl Infect Dis. 1999;1 Suppl 1:8–12.

    PubMed  Google Scholar 

  94. Rashtak S, Dierkhising RA, Kremers WK, Peters SG, Cassivi SD, Otley CC. Incidence and risk factors for skin cancer following lung transplantation. J Am Acad Dermatol. 2015;72:92–8.

    Article  PubMed  Google Scholar 

  95. Harwood CA, Surentheran T, McGregor JM, Spink PJ, Leigh IM, Breuer J, Proby CM. Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol. 2000;61:289–97.

    Article  CAS  PubMed  Google Scholar 

  96. Feist A, Lee R, Osborne S, Lane J, Yung G. Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole. J Heart Lung Transplant. 2012;31:1177–81.

    Article  PubMed  Google Scholar 

  97. Dufek S, Haitel A, Muller-Sacherer T, Aufricht C. Duct Bellini carcinoma in association with BK virus nephropathy after lung transplantation. J Heart Lung Transplant. 2013;32:378–9.

    Article  PubMed  Google Scholar 

  98. Torbenson M, Wang J, Nichols L, Randhawa P, Nalesnik MA. Renal cortical neoplasms in long term survivors of solid organ transplantation. Transplantation. 2000;69:864–8.

    Article  CAS  PubMed  Google Scholar 

  99. Collins J, Kazerooni EA, Lacomis J, McAdams HP, Leung AN, Shiau M, Semenkovich J, Love RB. Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology. 2002;224:131–8.

    Article  PubMed  Google Scholar 

  100. Penn I. Kaposi’s sarcoma in transplant recipients. Transplantation. 1997;64:669–73.

    Article  CAS  PubMed  Google Scholar 

  101. Nannini N, Rebusso A, Lunardi F, Loy M, Calabrese F, Battistella L, Schiavon M, Rea F, Calabrese F. A symptomatic pulmonary allograft Kaposi’s sarcoma: a case report. Exp Clin Transplant. 2016 Jan 14. [Epub ahead of print].

    Google Scholar 

  102. Regamey N, Tamm M, Wernli M, Witschi A, Thiel G, Cathomas G, Erb P. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med. 1998;339:1358–63.

    Article  CAS  PubMed  Google Scholar 

  103. Piselli P, Busnach G, Citterio F, Frigerio M, Arbustini E, Burra P, Pinna AD, Bresadola V, Ettorre GM, Baccarani U, Buda A, Lauro A, Zanus G, Cimaglia C, Spagnoletti G, Lenardon A, Agozzino M, Gambato M, Zanfi C, Miglioresi L, Di Gioia P, Mei L, Ippolito G, Serraino D, Immunosuppression and Cancer Study Group. Risk of Kaposi sarcoma after solid-organ transplantation: multicenter study in 4,767 recipients in Italy, 1970–2006. Transplant Proc. 2009;41:1227–30.

    Article  CAS  PubMed  Google Scholar 

  104. Smith DM, Agura ED, Ausloos K, Ring WS, Domiati-Saad R, Klintmalm GB. Graft-vs-host disease as a complication of lung transplantation. J Heart Lung Transplant. 2006;25:1175–7.

    Article  PubMed  Google Scholar 

  105. Assi MA, Pulido JS, Peters SG, McCannel CA, Razonable RR. Graft-vs.-host disease in lung and other solid organ transplant recipients. Clin Transplant. 2007;21:1–6.

    Article  PubMed  Google Scholar 

  106. Worel N, Bojic A, Binder M, Jaksch P, Mitterbauer G, Streubel B, Thalhammer F, Staudinger T, Laczika KF, Locker GJ. Catastrophic graft-versus-host disease after lung transplantation proven by PCR-based chimerism analysis. Transpl Int. 2008;21:1098–101.

    PubMed  Google Scholar 

  107. Kazerooni EA, Jackson C, Cascade PN. Sarcoidosis: recurrence of primary disease in transplanted lungs. Radiology. 1994;192:461–4.

    Article  CAS  PubMed  Google Scholar 

  108. Martinez FJ, Orens JB, Deeb M, Brunsting LA, Flint A, Lynch 3rd JP. Recurrence of sarcoidosis following bilateral allogeneic lung transplantation. Chest. 1994;106:1597–9.

    Article  CAS  PubMed  Google Scholar 

  109. Calabrese F, Giacometti C, Rea F, Loy M, Sartori F, Di Vittorio G, Abudureheman A, Thiene G, Valente M. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation. 2002;74:1643–5.

    Article  PubMed  Google Scholar 

  110. Gabbay E, Dark JH, Ashcroft T, Milne D, Gibson GJ, Healy M, Corris PA. Recurrence of Langerhans’ cell granulomatosis following lung transplantation. Thorax. 1998;53:326–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Habib SB, Congleton J, Carr D, Partridge J, Corrin B, Geddes DM, Banner N, Yacoub M, Burke M. Recurrence of recipient Langerhans’ cell histiocytosis following bilateral lung transplantation. Thorax. 1998;53:323–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. O’Brien JD, Lium JH, Parosa JF, Deyoung BR, Wick MR, Trulock EP. Lymphangiomyomatosis recurrence in the allograft after single-lung transplantation. Am J Respir Crit Care Med. 1995;151:2033–6.

    Article  PubMed  Google Scholar 

  113. Bittmann I, Dose TB, Muller C, Dienemann H, Vogelmeier C, Lohrs U. Lymphangioleiomyomatosis: recurrence after single lung transplantation. Hum Pathol. 1997;28:1420–3.

    Article  CAS  PubMed  Google Scholar 

  114. Verleden GM, Sels F, Van Raemdonck D, Verbeken EK, Lerut T, Demedts M. Possible recurrence of desquamative interstitial pneumonitis in a single lung transplant recipient. Eur Respir J. 1998;11:971–4.

    Article  CAS  PubMed  Google Scholar 

  115. Baz MA, Kussin PS, Van Trigt P, Davis RD, Roggli VL, Tapson VF. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med. 1995;151:895–8.

    Article  CAS  PubMed  Google Scholar 

  116. Mal H, Guignabert C, Thabut G, d’Ortho MP, Brugiere O, Dauriat G, Marrash-Chahla R, Rangheard AS, Leseche G, Fournier M. Recurrence of pulmonary emphysema in an alpha-1 proteinase inhibitor-deficient lung transplant recipient. Am J Respir Crit Care Med. 2004;170:811–4.

    Article  PubMed  Google Scholar 

  117. Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH. Sirolimus-associated pulmonary toxicity. Transplantation. 2004;77:1215–20.

    Article  CAS  PubMed  Google Scholar 

  118. Garrean S, Massad MG, Tshibaka M, Hanhan Z, Caines AE, Benedetti E. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant. 2005;19:698–703.

    Article  PubMed  Google Scholar 

  119. Hamour IM, Mittal TK, Bell AD, Banner NR. Reversible sirolimus-associated pneumonitis after heart transplantation. J Heart Lung Transplant. 2006;25:241–4.

    Article  PubMed  Google Scholar 

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  1. University of Padova Medical School, Department of Cardiothoracic and Vascular Sciences, Pathological Anatomy Section, Padova, Italy

    Fiorella Calabrese PhD

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Calabrese, F. (2017). Lung Transplantation-Related Pathology. In: Pathology of Lung Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50491-8_16

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