SpringerLink
Log in

Vaccines Against Peste des Petits Ruminants Virus

  • Chapter
  • First Online:
Peste des Petits Ruminants Virus

Abstract

Peste des petits ruminants (PPR) is an acute and highly contagious viral disease of sheep, goats and wild ruminants. The disease is controlled by the use of live-attenuated vaccines that give a lifelong immunity. Currently, several PPR vaccines are available for use in the field that are based on the tissue culture passage attenuation of wild-type PPR isolates. Four such preparations, viz., PPRV/Nigeria/75, PPRV/Sungri/96, PPRV/Arasur/87 and PPRV/Coimbatore/97 are licensed for use. The PPR vaccines comprising of PPRV/Nigeria/75 and PPRV/Sungri/96 are commercially available. While highly efficacious, a drawback to these vaccines is the requirement of a cold chain to preserve vaccine titre in the field. Thermostable live-attenuated vaccines have recently been developed in an attempt to circumvent the problems associated with the maintenance of a cold chain in tropical and subtropical countries. Despite this issue, targeted vaccination programmes for PPR in high-risk populations of sheep and goats constitute an effective control strategy. Lessons learnt from the rinderpest eradication programme suggest that the availability of a DIVA vaccine, to enable the differentiation between infected and vaccinated animals (DIVA), and a companion diagnostic test would greatly aid both the control and the surveillance for PPRV although it is recognised that eradication could be achieved in the absence of these tools. In this chapter, we discuss both the current and potential future vaccine strategies for PPRV and highlight elements of vaccines that are highly desirable in newer vaccine preparations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Anderson J, Mc Kay J (1994) The detection of antibodies against peste des petits ruminants virus in cattle, sheep and goats and the possible implications to rinderpest control programmes. Epidemio Infect 112:225–231

    Article  CAS  Google Scholar 

  • Anon (2008) Annual Report (2007–2008). Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India, pp 26–27

    Google Scholar 

  • Asim M, Rashid A, Chaudhary AH, Noor MS (2009) Production of homologous live attenuated cell culture vaccine for the control of peste des petits ruminants in small ruminants. Pakistan Vet J 29(2):72–74

    CAS  Google Scholar 

  • Balamurugan V, Sen A, Saravanan P, Singh RP, Singh RK, Bandyopadhyay SK (2006) One step multiplex RT-PCR for the detection of peste des petits ruminants virus in clinical samples. Vet Res Commun 30:655–666

    Article  CAS  PubMed  Google Scholar 

  • Balamurugan V, Singh RP, Saravanan P, Sen A, Sarkar J, Sahay B, Rasool TJ, Singh RK (2007) Development of an indirect ELISA for the detection of antibodies against peste des petits ruminants virus in small ruminants. Vet Res Commun 31:355–364

    Article  CAS  PubMed  Google Scholar 

  • Benazet BGH (1973) La peste des petits ruminants: Etude experimentale de la vaccination C.f. Taylor WP (1984)

    Google Scholar 

  • Berhe G, Minet C, Le Goff C et al (2003) Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections. J Virol 77:1571–1577

    Google Scholar 

  • Bhanuprakash V, Indrani BK, Hosamani M, Singh RK (2006) The current status of sheep pox disease. Comp Immunol Microbiol Infect Dis 29:27–60

    Article  CAS  PubMed  Google Scholar 

  • Bourdin P, Rioche M, Laurent A (1970) Emploi d’un vaccin anti-bovipestique produit sur cultures cellulaires dans la prophylaxie de la peste des petits ruminants au Dahomey. Rev Elev Med Vet Pays Trop 23:295–300

    Google Scholar 

  • Chaudhary SS, Pandey KD, Singh RP, Verma PC, Gupta PK (2009) A Vero cell derived combined vaccine against sheep pox and peste des petits ruminants for sheep. Vaccine 27(19–28):548–2553

    Google Scholar 

  • Couacy-Hymann ERF, Bidjeh K, Angba A, Domenech J, Diallo A (1995) Protection of goats against rinderpest by vaccination with attenuated peste des petits ruminants virus. Res Vet Sci 59:106–109

    Article  CAS  PubMed  Google Scholar 

  • Couacy-Hymann ERF, Hurard C, Guillou JP, Libeau G, Diallo A (2002) Rapid and sensitive detection of peste des petits ruminants virus by a polymerase chain reaction assay. J Virol Methods 100:17–25

    Article  CAS  PubMed  Google Scholar 

  • Dardiri AH, De Boer CJ, Hadry FM (1976) Response of American goats and cattle to peste des petits ruminants. In: Proceedings of the 19th annual meeting of the American Association of Veterinary Laboratory Diagnosticians, pp. 337–344

    Google Scholar 

  • Diallo A, Minet C, Le Goff C et al (2007) The threat of peste des petits ruminants: progress in vaccine development for disease control. Vaccine 25:5591–5597

    Google Scholar 

  • Diallo A, Taylor WP, Lefevre PC, Provosta A (1989) Attenuation of a virulent PPR strain potential homologus live vaccine. Rev Elev Med Vet Pays Trop 42(3):311–319

    CAS  PubMed  Google Scholar 

  • FAO (2010) ‘Deadly animal virus Peste des Petits Ruminants threatens to spread to souther Africa’, Goal Geology, viewed 16 January 2011, from www.animal-virus-peste-des-petits-ruminants-threatens-to-spread-to-southern-africa/8302/. Accessed 8 Nov 2013

  • Forsyth MA, Barrett T (1995) Detection and differentiation of rinderpest and peste des petits ruminants viruses in diagnostic and experimental samples by polymerase chain reaction using P and F gene-specific primers. Virus Res 39:151–163

    Article  CAS  PubMed  Google Scholar 

  • Gibbs EPJ, Taylor WP, Lawman MJP, Bryant J (1979) Classification of peste des petits ruminants virus as the fourth member of the genus Morbillivirus. Intervirology 11:268–274

    Article  CAS  PubMed  Google Scholar 

  • Gilbert Y, Monnier J (1962) Adaptation of the virus of peste des petits ruminants to tissue cultures. Rev Elev Med Vet Pays trop 15(4):321–335

    Google Scholar 

  • Guillemin F, Mosienyane M, Richard T, Mannathoko M (1987) Immune response and challenge of cattle vaccinated simultaneously against rinderpest and foot-and-mouth disease. Revue d'elevage et de Medecine Veterinaire des Pays Tropicaux 40:225–229

    Google Scholar 

  • Hedger RS, Taylor WP, Barnett IT, Riek R, Harpham D (1986) Simultaneous vaccination of cattle against foot-and-mouth disease and rinderpest. Trop Anim Health Prod 18:21–25

    Google Scholar 

  • Hosamani M, Singh SK, Mondal B, Sen A, Bhanuprakash V, Bandyopadhyay SK, Yadav MP, Singh RK (2006) A bivalent vaccine against goat pox and Peste des Petits ruminants induces protective immune response in goats. Vaccine 24:6058–6064

    Article  CAS  PubMed  Google Scholar 

  • Kathuria BK, Uppal PK, Kumar S (1976) Studies on simuktaneous vaccination of cattle against rinderpest and foot and mouth disease. Indian Vet J 53:571–576.

    Google Scholar 

  • Laurent A (1968) Aspects biologiques de la multiplication du virus de la peste des petits ruminants sur les cultures cellulaire. Rev Elev Méd Vét Pays Trop 21:297–308

    CAS  PubMed  Google Scholar 

  • Macadam I, Ezebuiro EO, Oreffo VOC (1964) The response of zebu cattle to mixed contagious bovine pleuro-pneumonia and tissue culture rinderpest vaccines. Bull Epizoot Dis Afr 12:237–240

    Google Scholar 

  • Mariner JC, van den Ende MC, House JA, Mebus CA, Salifou S, Stem C (1990) The serological response to a thermostable Vero cell-adapted rinderpest vaccine under field conditions in Niger. Vet Microbiol 22:119–127

    Google Scholar 

  • Matrencher A, Zoyem N, Diallo A (1997) Experimental study of a mixed vaccine against Peste des petits ruminants and capripox infection in goats in northern Cameroon. Small Ruminant Res 26:39–44

    Article  Google Scholar 

  • Mornet P, Orue J, Gillbert Y, Thiery G, Sow M (1956) La peste des petits Ruminants en Afrique occidentale française ses rapports avec la Peste Bovine. Revue d’elevage et de Medecine Veterinaire des Pays Tropicaux 9:313–342

    Google Scholar 

  • Palaniswami KS (2005) Peste des petits ruminants: strategies for control and eradication. Presented at: national seminar on pesticide, antibiotic residues and other toxins in feed, livestock and poultry products and strategies for control and eradication of peste des petits ruminants. Bangalore, India, 10–11 december 2005

    Google Scholar 

  • Perry BD, Randolph TF, McDermott JJ, Sones KR, Thornton PK (2002) Investing in Animal Health Research to Alleviate Poverty. Nairobi, Kenya, International Livestock Research Institute

    Google Scholar 

  • Plowright W, Ferris RD (1959a) Studies with Rinderpest virus in tissue culture. J Comp Pathol 69:152–171

    Article  CAS  PubMed  Google Scholar 

  • Plowright W, Ferris RD (1959b) Studies with Rinderpest virus in tissue culture II: pathogenicity of cattle for culture passaged virus. J Comp Pathol 69:173–184

    Article  CAS  PubMed  Google Scholar 

  • Plowright W, Ferris RD (1962) Studies with Rinderpest virus in tissue culture: the use of attenuated virus as a vaccine for cattle. Res Vet Sci 3:172

    Google Scholar 

  • Plowright W, Herniman KA, Rampton CS (1971) Studies on rinderpest culture vaccine. IV. The stability of the reconstituted product. Res Vet Sci 12:40–46

    Google Scholar 

  • Plowright W, Rampton CS, Taylor WP, Herniman KA (1970) Studies on rinderpest culture vaccine. III. Stability of the lyophilised product. Res Vet Sci 11:71–81

    Google Scholar 

  • Provost A., Borredon C, Queval R (1969) Recherches immunologiques sur la peri-pneumonie. XI. Un vaccin vivant mixte antibovipestique antiperipneumonique inocule en un seul temps. Conception-production-controles. Bull Off Int Epizoot 72:166–203

    Google Scholar 

  • Rajak KK, Sreenivasa BP, Hosamani M, Singh RP, Singh SK, Singh RK, Bandyopadhyay SK (2005) Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats. Comp Immunol Microbiol Infect Dis 28:287–296

    Article  CAS  PubMed  Google Scholar 

  • Riyesh T, Balamurugan V, Sen A, Bhanuprakash V, Venkatesan G, Yadav V, Singh RK (2011) Evaluation of efficacy of stabilizers on the thermostability of live attenuated thermo-adapted Peste des petits ruminants vaccines. Virol Sin 26(5):324–337

    Article  CAS  PubMed  Google Scholar 

  • Roeder PL (2011) Rinderpest: the end of cattle plague. Prev Vet Med 102:98–106

    Article  PubMed  Google Scholar 

  • Saravanan P, Singh RP, Balamurugan V, Dhar P, Sreenivasa BP, Muthuchelvan D, Sen A, Aleyas AG, Singh RK, Bandyopadhyay SK (2004) Development of a N gene-based PCR-ELISA for detection of Peste-des-petits ruminants virus in clinical samples. Acta Virol 48(4):249–255

    CAS  PubMed  Google Scholar 

  • Saravanan P, Balamurugan V, Sen A et al (2010a) Longterm immune response of goats to a Vero cell adapted live attenuated homologous PPR vaccine. Indian Vet J 87:1–3

    CAS  Google Scholar 

  • Saravanan P, Sen A, Balamurugan V, Palaniswami KS, Nachimuthu K, Thangavelu A, Dhinakarraj G, Hegde R, Singh RK (2010b) Comparative efficacy of peste des petits ruminants (PPR) vaccines. Biologicals 38:479–485

    Article  CAS  PubMed  Google Scholar 

  • Sarkar J, Sreenivasa BP, Singh RP, Dhar P, Bandyopadhyay SK (2003) Comparative efficacy of various chemical stabilizers on the thermostability of a live-attenuated peste des petits ruminants (PPR) vaccine. Vaccine 21:4728–4735

    Article  CAS  PubMed  Google Scholar 

  • Sen A, Saravanan P, Balamurugan V, Rajak KK, Sudhakar SB, Bhanuprakash V, Parida S, Singh RK (2010) Vaccines against peste des petits ruminants virus. Expert Rev Vaccines 9:785–796

    Article  CAS  PubMed  Google Scholar 

  • Singh RP (2011) Control strategies for peste des petits ruminants in small ruminants of India. Revue Scientifique et Technique 30:879–887

    Google Scholar 

  • Singh RP, Sreenivasa BP, Bandyopadhyay SK (2004a) Prevalence and distribution of peste des petits ruminants (PPR) virus infection in small ruminants in India. Rev Sci tech int Epiz 23:807–819

    CAS  Google Scholar 

  • Singh RP, Sreenivasa BP, Dhar P, Bandyopadhyay SK (2004b) A sandwich-ELISA for the diagnosis of Peste des petits ruminants (PPR) infection in small ruminants using anti-nucleocapsid protein monoclonal antibody. Arch Virol 149:2155–2170

    Article  CAS  PubMed  Google Scholar 

  • Singh RK, Balamurugan V, Bhanuprakash V, Sen A, Saravanan P, Yadav MP (2009) Possible control and eradication of peste des petits ruminants from India: technical aspects. Vet Italiana 45(3):449–462

    Google Scholar 

  • Singh RP, De UK, Pandey KD (2010) Virological and antigenic characterization of two peste des petits ruminants (PPR) vaccine viruses of Indian origin. Comp Immunol Microbiol Infect Dis 33:343–353

    Article  CAS  PubMed  Google Scholar 

  • Sreenivasa BP, Dhar P, Singh RP and Bandyopadhyay SK (2000) Evaluation of an indigenously developed homologous live attenuated cell culture vaccine against peste des petits ruminants infection of small ruminants. Abstract in the proceedings of “XX Annual Conference of Indian Association of Veterinary Microbiologists, Immunologists and Specialists in Infectious Diseases”, p 84, Pantnagar, India, 14–16 october 2000

    Google Scholar 

  • Taylor WP (1979) Protection of goats against peste-des-petits-ruminants with attenuated rinderpest virus. Res Vet Sci 27:321–324

    Google Scholar 

  • Taylor WP, Abegunde A (1979) The isolation of peste des petits ruminants virus from Nigerian sheep and goats. Res Vet Sci 26(1):94–96

    CAS  PubMed  Google Scholar 

  • Worrall EE, Litamoi JK, Seck BM, Ayelet G (2000) Xerovac: an ultra rapid method for the dehydaration and preservation of live attenuated rinderpest and peste des petits ruminants vaccines. Vaccine 19:834–839

    Article  CAS  PubMed  Google Scholar 

  • Yadav V, Balamurugan V, Bhanuprakash V, Sen A, Bhanot V, Venkatesan G, Riyesh T, Singh RK (2009) Expression of Peste des petits ruminants virus nucleocapsid protein in prokaryotic system and its potential use as a diagnostic antigen or immunogen. J Virol Methods 162:56–63

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Indian Veterinary Research Institute, Bareilly, 263138, Uttar Pradesh, India

    R. K. Singh

  2. Division of Virology, Indian Veterinary Research Institute, Campus Mukteswar, Nainital, 263138, Uttarakhand, India

    K. K. Rajak & D. Muthuchelvan

  3. Animal and Plant Health Agency, Woodham Lane, Weybridge, Surrey, KT15 3NB, UK

    Ashley C. Banyard

  4. The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK

    Satya Parida

Authors
  1. R. K. Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. K. Rajak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Muthuchelvan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ashley C. Banyard
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Satya Parida
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. K. Singh .

Editor information

Editors and Affiliations

  1. The Pirbright Institute, Pirbright, Surrey, United Kingdom

    Muhammad Munir

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Singh, R.K., Rajak, K.K., Muthuchelvan, D., Banyard, A.C., Parida, S. (2015). Vaccines Against Peste des Petits Ruminants Virus. In: Munir, M. (eds) Peste des Petits Ruminants Virus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45165-6_11

Download citation

Publish with us

Policies and ethics

Search

Navigation