Abstract
An imbalance between the production of free radicals and availability of appropriate antioxidant species is termed as oxidative stress. We review some of the evidence implicating an important role for oxidative stress in the pathophysiology of cardiovascular disease. A major contributor to oxidative stress is a family of reactive oxygen species (ROS) that are unstable molecules and contain one or more unpaired electrons in atomic or molecular orbitals that readily react with other molecules. Not only can ROS contribute to oxidative stress in general, but individual species of ROS have their own distinct properties and may activate diverse signaling pathways. Activation of these signaling pathways leads to distinct pathological changes associated with cardiovascular disease cascades.
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Elahi, M.M., Chuang, A., Matata, B.M. (2014). Overview of Oxidative Stress and Cardiovascular Disease. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_42
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