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Technical Aspects of Renal Pathology

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Pediatric Nephrology

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Abstract

This chapter reviews technical aspects and different methods of obtaining kidney biopsy material and allocation of the biopsy specimens. We describe the types of microscopy used to analyze the tissue, including light microscopy with special stains, immunofluorescence microscopy, including salvage techniques from paraffin tissue, and electron microscopy. We describe normal morphology and common, classic morphologic patterns of injury. We also describe selected specific patterns of injury, including mesangial versus endocapillary hypercellularity, membranoproliferative pattern, exudative pattern, crescents, segmental sclerosis, thrombosis, acute tubular injury, interstitial fibrosis/tubular atrophy, and acute interstitial nephritis. Lastly, prognostic implications of biopsy findings and new methods on the horizon are briefly discussed.

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Authors and Affiliations

  1. Arkana Laboratories, Little Rock, AR, USA

    Patrick D. Walker

  2. Institut für Pathologie, Koln, Germany

    Jan U. Becker

  3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Agnes B. Fogo

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  1. Patrick D. Walker
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  2. Jan U. Becker
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  3. Agnes B. Fogo
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Correspondence to Agnes B. Fogo .

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Editors and Affiliations

  1. Division of Nephrology, Bambino Gesù Children’s Hospital –, ROMA, Roma, Italy

    Francesco Emma

  2. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, OH, USA

    Stuart Goldstein

  3. Division of Nephrology, All India Institute of Medical Sciences, Ansari Nagar East, Delhi, India

    Arvind Bagga

  4. Division of Pediatric Nephrology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

    Carlton M. Bates

  5. Renal Unit, Graet Ormond Street Hospital, London, UK

    Rukshana Shroff

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Walker, P.D., Becker, J.U., Fogo, A.B. (2021). Technical Aspects of Renal Pathology. In: Emma, F., Goldstein, S., Bagga, A., Bates, C.M., Shroff, R. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_22-2

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  • DOI: https://doi.org/10.1007/978-3-642-27843-3_22-2

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  1. Latest

    Technical Aspects of Renal Pathology
    Published:
    16 March 2022

    DOI: https://doi.org/10.1007/978-3-642-27843-3_22-2

  2. Original

    Pediatric Renal Pathology
    Published:
    20 November 2014

    DOI: https://doi.org/10.1007/978-3-642-27843-3_22-1

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