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Mechanisms of Pain

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Pain Imaging

Abstract

The chapter describes in summary the main mechanism of pain based on peripheral receptors and biochemical mediators. The pathways of pain and the central nervous system centers for pain are described. Different and the current hypothesis of pain modulation, sensitization, and manipulation are described. The concept of pain matrix based on the modern functional neuromaging in humans is reported. The descending control of brainstem on spinal mechanisms and the importance of attention and cognitive state on pain perception and elaboration are described.

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Authors and Affiliations

  1. Clinical Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

    Paolo Manganotti

  2. Clinical Neurology Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, GB Rossi Hospital, Verona, Italy

    Stefano Tamburin

Authors
  1. Paolo Manganotti
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  2. Stefano Tamburin
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Corresponding author

Correspondence to Paolo Manganotti .

Editor information

Editors and Affiliations

  1. Department of Radiology, Cattinara Hospital, University of Trieste, Trieste, Italy

    Maria Assunta Cova

  2. Department of Radiology, Maggiore Hospital, Trieste, Italy

    Fulvio Stacul

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Manganotti, P., Tamburin, S. (2019). Mechanisms of Pain. In: Cova, M., Stacul, F. (eds) Pain Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-99822-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-99822-0_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-99821-3

  • Online ISBN: 978-3-319-99822-0

  • eBook Packages: MedicineMedicine (R0)

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