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Production of Ginsenosides by Hairy Root Cultures of Panax ginseng

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Production of Plant Derived Natural Compounds through Hairy Root Culture

Abstract

Panax ginseng C. A. Meyer, commonly known as ginseng, is a popular medicinal plant, used as a traditional medicine in many countries. Ginsenosides are triterpene compounds which have multiple biological and pharmaceutical applications including neuroprotection, anticancer, antidiabetic, hepatoprotective, and immunomodulatory activities. Cultivation of ginseng till harvest of matured roots takes 5–7 years, whereas wild ginseng is rare and a highly expensive commodity. Therefore, many researchers studied biotechnological means especially cell and organ cultures for the production of ginsenosides. Transformed hairy roots were induced in ginseng, and they were cultured in vitro for biomass and secondary metabolite production. Various chemical and physical parameters have been worked out for optimal biomass and ginsenoside accumulation. Several researchers have tested bioreactor system for cultivation of ginseng hairy roots to produce ginsenosides. This review highlights the recent progress in the hairy root induction, selection of elite clones, establishment of suspension culture, strategies adopted for biomass, and bioactive compound production.

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Acknowledgments

HNM is thankful to KOSEF, Republic of Korea, for awarding Brain Pool Fellowship. This work is partly supported by DST-PURSE Phase 2 program.

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Authors and Affiliations

  1. Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, Republic of Korea

    Hosakatte Niranjana Murthy, So Young Park & Kee Yoeup Paek

  2. Department of Botany, Karnatak University, Dharwad, India

    Hosakatte Niranjana Murthy

Authors
  1. Hosakatte Niranjana Murthy
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  2. So Young Park
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  3. Kee Yoeup Paek
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Correspondence to Hosakatte Niranjana Murthy .

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Editors and Affiliations

  1. Biological and Health Sciences Center, Federal University of Maranhao, Sao Luis, Maranhão, Brazil

    Sonia Malik

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Murthy, H.N., Park, S.Y., Paek, K.Y. (2017). Production of Ginsenosides by Hairy Root Cultures of Panax ginseng . In: Malik, S. (eds) Production of Plant Derived Natural Compounds through Hairy Root Culture . Springer, Cham. https://doi.org/10.1007/978-3-319-69769-7_11

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