SpringerLink
Log in

The Biology and Epidemiology of Mycobacterium canettii

  • Chapter
  • First Online:
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1019))

Abstract

Genome-based insights into the evolution of Mycobacterium tuberculosis and other tuberculosis-causing mycobacteria are constantly increasing. In particular, the recent genomic and functional characterization of several Myocbacterium canettii strains, which are thought to resemble in many aspects the putative common ancestor of the members of the M. tuberculosis complex (MTBC), has consolidated a plausible scenario of the early evolution of tuberculosis-causing mycobacteria, in which the clonal MTBC, comprising numerous key pathogens of mammalian hosts, has evolved from a generalist mycobacterium living in the environment. These studies also have considerably enriched our knowledge on selected molecular events that likely have contributed to the incursion, maintenance and spread of the MTBC members in diverse mammalian hosts. Here, we summarize and discuss recently revealed molecular and evolutionary aspects and emphasize the vast utility of M. canettii strains for identifying the mechanisms that contributed to the global emergence of M. tuberculosis as one of the most important human pathogens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (France)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 149.79
Price includes VAT (France)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 189.89
Price includes VAT (France)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
EUR 189.89
Price includes VAT (France)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Alexander KA, Laver PN, Michel AL, Williams M, van Helden PD, Warren RM, Gey van Pittius NC (2010) Novel Mycobacterium tuberculosis complex pathogen, M. mungi. Emerg Infect Dis 16(8):1296–1299

    Article  PubMed  PubMed Central  Google Scholar 

  • Alexander KA, Sanderson CE, Larsen MH, Robbe-Austerman S, Williams MC, Palmer MV (2016) Emerging tuberculosis pathogen hijacks social communication behavior in the group-living banded mongoose (Mungos mungo). MBio 7(3):e00281–e00216

    CAS  PubMed  PubMed Central  Google Scholar 

  • Aranaz A, Liebana E, Gomez-Mampaso E, Galan JC, Cousins D, Ortega A, Blazquez J, Baquero F, Mateos A, Suarez G, Dominguez L (1999) Mycobacterium tuberculosis subsp. caprae subsp. nov.: a taxonomic study of a new member of the Mycobacterium tuberculosis complex isolated from goats in Spain. Int J Syst Bacteriol 49(Pt 3):1263–1273

    Article  CAS  PubMed  Google Scholar 

  • Banu S, Honore N, Saint-Joanis B, Philpott D, Prevost MC, Cole ST (2002) Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? Mol Microbiol 44(1):9–19

    Article  CAS  PubMed  Google Scholar 

  • Blouin Y, Hauck Y, Soler C, Fabre M, Vong R, Dehan C, Cazajous G, Massoure PL, Kraemer P, Jenkins A, Garnotel E, Pourcel C, Vergnaud G (2012) Significance of the identification in the Horn of Africa of an exceptionally deep branching Mycobacterium tuberculosis clade. PLoS One 7(12):e52841

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blouin Y, Cazajous G, Dehan C, Soler C, Vong R, Hassan MO, Hauck Y, Boulais C, Andriamanantena D, Martinaud C, Martin E, Pourcel C, Vergnaud G (2014) Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti. Emerg Infect Dis 20(1):21–28

    Article  PubMed  PubMed Central  Google Scholar 

  • Boritsch EC, Brosch R (2016) Evolution of Mycobacterium tuberculosis: new insights into pathogenicity and drug resistance. Microbiol Spectr 4(5):TBTB2-0020-2016

    Google Scholar 

  • Boritsch EC, Supply P, Honore N, Seemann T, Stinear TP, Brosch R (2014) A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent. Mol Microbiol 93(5):835–852

    Article  CAS  PubMed  Google Scholar 

  • Boritsch EC, Frigui W, Cascioferro A, Malaga W, Etienne G, Laval F, Pawlik A, Le Chevalier F, Orgeur M, Ma L, Bouchier C, Stinear TP, Supply P, Majlessi L, Daffe M, Guilhot C, Brosch R (2016a) pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence. Nat Microbiol 1(2):15019

    Article  CAS  PubMed  Google Scholar 

  • Boritsch EC, Khanna V, Pawlik A, Honore N, Navas VH, Ma L, Bouchier C, Seemann T, Supply P, Stinear TP, Brosch R (2016b) Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria. Proc Natl Acad Sci U S A 113(35):9876–9881

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bos KI, Harkins KM, Herbig A, Coscolla M, Weber N, Comas I, Forrest SA, Bryant JM, Harris SR, Schuenemann VJ, Campbell TJ, Majander K, Wilbur AK, Guichon RA, Wolfe Steadman DL, Cook DC, Niemann S, Behr MA, Zumarraga M, Bastida R, Huson D, Nieselt K, Young D, Parkhill J, Buikstra JE, Gagneux S, Stone AC, Krause J (2014) Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis. Nature 514(7523):494–497

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bottai D, Brosch R (2009) Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families. Mol Microbiol 73(3):325–328

    Article  CAS  PubMed  Google Scholar 

  • Brisse S, Supply P, Brosch R, Vincent V, Gutierrez MC (2006) “A re-evaluation of M. prototuberculosis”: continuing the debate. PLoS Pathog 2(9):e95

    Article  PubMed  PubMed Central  Google Scholar 

  • Brosch R, Guilhot C (2015) Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans. Med Sci (Paris) 31(2):123–126

    Article  Google Scholar 

  • Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST (2002) A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc Natl Acad Sci U S A 99(6):3684–3689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cadieux N, Parra M, Cohen H, Maric D, Morris SL, Brennan MJ (2011) Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 protein. Microbiology 157(Pt 3):793–804

    Article  CAS  PubMed  Google Scholar 

  • Canetti G (1965) The J. Burns Amberson lecture. Present aspects of bacterial resistance in tuberculosis. Am Rev Respir Dis 92:687

    CAS  PubMed  Google Scholar 

  • Carver T, Berriman M, Tivey A, Patel C, Bohme U, Barrell BG, Parkhill J, Rajandream MA (2008) Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database. Bioinformatics 24(23):2672–2676

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393(6685):537–544

    Article  CAS  PubMed  Google Scholar 

  • Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S, Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S (2013) Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet 45(10):1176–1182

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Comas I, Hailu E, Kiros T, Bekele S, Mekonnen W, Gumi B, Tschopp R, Ameni G, Hewinson RG, Robertson BD, Goig GA, Stucki D, Gagneux S, Aseffa A, Young D, Berg S (2015) Population genomics of Mycobacterium tuberculosis in Ethiopia contradicts the virgin soil hypothesis for human tuberculosis in Sub-Saharan Africa. Curr Biol 25(24):3260–3266

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coros A, Callahan B, Battaglioli E, Derbyshire KM (2008) The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis. Mol Microbiol 69(4):794–808

    CAS  PubMed  PubMed Central  Google Scholar 

  • Coscolla M, Lewin A, Metzger S, Maetz-Rennsing K, Calvignac-Spencer S, Nitsche A, Dabrowski PW, Radonic A, Niemann S, Parkhill J, Couacy-Hymann E, Feldman J, Comas I, Boesch C, Gagneux S, Leendertz FH (2013) Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee. Emerg Infect Dis 19(6):969–976

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cousins DV, Bastida R, Cataldi A, Quse V, Redrobe S, Dow S, Duignan P, Murray A, Dupont C, Ahmed N, Collins DM, Butler WR, Dawson D, Rodriguez D, Loureiro J, Romano MI, Alito A, Zumarraga M, Bernardelli A (2003) Tuberculosis in seals caused by a novel member of the Mycobacterium tuberculosis complex: Mycobacterium pinnipedii sp. nov. Int J Syst Evol Microbiol 53(Pt 5):1305–1314

    Article  CAS  PubMed  Google Scholar 

  • Daffe M, McNeil M, Brennan PJ (1991) Novel type-specific lipooligosaccharides from Mycobacterium tuberculosis. Biochemistry 30(2):378–388

    Article  CAS  PubMed  Google Scholar 

  • de Jong BC, Antonio M, Gagneux S (2010) Mycobacterium africanum – review of an important cause of human tuberculosis in West Africa. PLoS Negl Trop Dis 4(9):e744

    Article  PubMed  PubMed Central  Google Scholar 

  • Delogu G, Pusceddu C, Bua A, Fadda G, Brennan MJ, Zanetti S (2004) Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Mol Microbiol 52(3):725–733

    Article  CAS  PubMed  Google Scholar 

  • Derbyshire KM, Gray TA (2014) Distributive conjugal transfer: new insights into horizontal gene transfer and genetic exchange in Mycobacteria. Microbiol Spectr 2(1):04

    Article  PubMed  PubMed Central  Google Scholar 

  • Domogalla J, Prodinger WM, Blum H, Krebs S, Gellert S, Muller M, Neuendorf E, Sedlmaier F, Buttner M (2013) Region of difference 4 in alpine Mycobacterium caprae isolates indicates three variants. J Clin Microbiol 51(5):1381–1388

    Article  PubMed  PubMed Central  Google Scholar 

  • Dormans J, Burger M, Aguilar D, Hernandez-Pando R, Kremer K, Roholl P, Arend SM, van Soolingen D (2004) Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse model. Clin Exp Immunol 137(3):460–468

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fabre M, Koeck JL, Le Fleche P, Simon F, Herve V, Vergnaud G, Pourcel C (2004) High genetic diversity revealed by variable-number tandem repeat genoty** and analysis of hsp65 gene polymorphism in a large collection of “Mycobacterium canettii” strains indicates that the M. tuberculosis complex is a recently emerged clone of “M. canettii”. J Clin Microbiol 42(7):3248–3255

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fabre M, Hauck Y, Soler C, Koeck JL, van Ingen J, van Soolingen D, Vergnaud G, Pourcel C (2010) Molecular characteristics of “Mycobacterium canettii” the smooth Mycobacterium tuberculosis bacilli. Infect Genet Evol J Mol Epidemiol Evol Genet Infect Dis 10(8):1165–1173

    CAS  Google Scholar 

  • Feuerriegel S, Koser CU, Richter E, Niemann S (2013) Mycobacterium canettii is intrinsically resistant to both pyrazinamide and pyrazinoic acid. J Antimicrob Chemother 68(6):1439–1440

    Article  CAS  PubMed  Google Scholar 

  • Feuerriegel S, Koser CU, Niemann S (2014) Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex. J Antimicrob Chemother 69(5):1205–1210

    Article  CAS  PubMed  Google Scholar 

  • Gagneux S, Small PM (2007) Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development. Lancet Infect Dis 7(5):328–337

    Article  PubMed  Google Scholar 

  • Gagneux S, Deriemer K, Van T, Kato-Maeda M, de Jong BC, Narayanan S, Nicol M, Niemann S, Kremer K, Gutierrez MC, Hilty M, Hopewell PC, Small PM (2006) Variable host-pathogen compatibility in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 103:2869–2873

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garnier T, Eiglmeier K, Camus JC, Medina N, Mansoor H, Pryor M, Duthoy S, Grondin S, Lacroix C, Monsempe C, Simon S, Harris B, Atkin R, Doggett J, Mayes R, Keating L, Wheeler PR, Parkhill J, Barrell BG, Cole ST, Gordon SV, Hewinson RG (2003) The complete genome sequence of Mycobacterium bovis. Proc Natl Acad Sci U S A 100(13):7877–7882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gonzalo-Asensio J, Malaga W, Pawlik A, Astarie-Dequeker C, Passemar C, Moreau F, Laval F, Daffe M, Martin C, Brosch R, Guilhot C (2014) Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator. Proc Natl Acad Sci U S A 111(31):11491–11496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gopinath K, Moosa A, Mizrahi V, Warner DF (2013) Vitamin B(12) metabolism in Mycobacterium tuberculosis. Future Microbiol 8(11):1405–1418

    Article  CAS  PubMed  Google Scholar 

  • Gray TA, Krywy JA, Harold J, Palumbo MJ, Derbyshire KM (2013) Distributive conjugal transfer in mycobacteria generates progeny with meiotic-like genome-wide mosaicism, allowing map** of a mating identity locus. PLoS Biol 11(7):e1001602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Groschel MI, Sayes F, Simeone R, Majlessi L, Brosch R (2016) ESX secretion systems: mycobacterial evolution to counter host immunity. Nat Rev Microbiol 14(11):677–691

    Article  CAS  PubMed  Google Scholar 

  • Gutierrez MC, Brisse S, Brosch R, Fabre M, Omais B, Marmiesse M, Supply P, Vincent V (2005) Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog 1(1):e5

    Article  PubMed  PubMed Central  Google Scholar 

  • Hendrix RW, Smith MC, Burns RN, Ford ME, Hatfull GF (1999) Evolutionary relationships among diverse bacteriophages and prophages: all the world’s a phage. Proc Natl Acad Sci U S A 96(5):2192–2197

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horstkotte MA, Sobottka I, Schewe CK, Schafer P, Laufs R, Rusch-Gerdes S, Niemann S (2001) Mycobacterium microti llama-type infection presenting as pulmonary tuberculosis in a human immunodeficiency virus-positive patient. J Clin Microbiol 39(1):406–407

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, Kuijper S, Bunschoten A, Molhuizen H, Shaw R, Goyal M, van Embden J (1997) Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol 35(4):907–914

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kelley DS, Lennon CW, Belfort M, Novikova O (2016) Mycobacteriophages as incubators for intein dissemination and evolution. MBio 7(5):e01537–e01516

    Article  PubMed  PubMed Central  Google Scholar 

  • Kiers A, Klarenbeek A, Mendelts B, Van Soolingen D, Koeter G (2008) Transmission of Mycobacterium pinnipedii to humans in a zoo with marine mammals. Int J Tuberc Lung Dis 12(12):1469–1473

    CAS  PubMed  Google Scholar 

  • Koeck JL, Bernatas JJ, Gerome P, Fabre M, Houmed A, Herve V, Teyssou R (2002) Epidemiology of resistance to antituberculosis drugs in Mycobacterium tuberculosis complex strains isolated from adenopathies in Djibouti. Prospective study carried out in 1999. Med Trop (Mars) 62(1):70–72

    CAS  Google Scholar 

  • Koeck JL, Fabre M, Simon F, Daffe M, Garnotel E, Matan AB, Gerome P, Bernatas JJ, Buisson Y, Pourcel C (2011) Clinical characteristics of the smooth tubercle bacilli ‘Mycobacterium canettii’ infection suggest the existence of an environmental reservoir. Clin Microbiol Infect 17(7):1013–1019

    Article  PubMed  Google Scholar 

  • Koro Koro F, Kamdem Simo Y, Piam FF, Noeske J, Gutierrez C, Kuaban C, Eyangoh SI (2013) Population dynamics of tuberculous Bacilli in Cameroon as assessed by spoligoty**. J Clin Microbiol 51(1):299–302

    Article  PubMed  PubMed Central  Google Scholar 

  • Kremer K, van Soolingen D, Frothingham R, Haas WH, Hermans PW, Martin C, Palittapongarnpim P, Plikaytis BB, Riley LW, Yakrus MA, Musser JM, van Embden JD (1999) Comparison of methods based on different molecular epidemiological markers for ty** of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility. J Clin Microbiol 37(8):2607–2618

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lemassu A, Levy-Frebault VV, Laneelle MA, Daffe M (1992) Lack of correlation between colony morphology and lipooligosaccharide content in the Mycobacterium tuberculosis complex. J Gen Microbiol 138(7):1535–1541

    Article  CAS  PubMed  Google Scholar 

  • Magee JG, Ward AC (2012) Genus I. Mycobacterium. In: Goodfellow M, Kämpfer P, Busse HJ et al (eds) Bergey’s manual of systematic bacteriology, the actinobacteria, vol 5, 2nd edn. Springer, New York, pp 312–375

    Google Scholar 

  • Makarova KS, Haft DH, Barrangou R, Brouns SJ, Charpentier E, Horvath P, Moineau S, Mojica FJ, Wolf YI, Yakunin AF, van der Oost J, Koonin EV (2011) Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol 9(6):467–477

    Article  CAS  PubMed  Google Scholar 

  • Mortimer TD, Pepperell CS (2014) Genomic signatures of distributive conjugal transfer among mycobacteria. Genome Biol Evol 6(9):2489–2500

    Article  PubMed  PubMed Central  Google Scholar 

  • Mostowy S, Cousins D, Behr MA (2004) Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex. J Bacteriol 186(1):104–109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muller B, Durr S, Alonso S, Hattendorf J, Laisse CJ, Parsons SD, van Helden PD, Zinsstag J (2013) Zoonotic Mycobacterium bovis-induced tuberculosis in humans. Emerg Infect Dis 19(6):899–908

    Article  PubMed  PubMed Central  Google Scholar 

  • Namouchi A, Didelot X, Schock U, Gicquel B, Rocha EP (2012) After the bottleneck: genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection. Genome Res 22(4):721–734

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nebenzahl-Guimaraes H, Yimer SA, Holm-Hansen C, de Beer J, Brosch R, van Soolingen D (2016) Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: “Aethiops vetus”. Microbial Genomics 2:e000063. doi:10.1099/mgen.0.000063

    Article  PubMed  PubMed Central  Google Scholar 

  • Panas MW, Jain P, Yang H, Mitra S, Biswas D, Wattam AR, Letvin NL, Jacobs WR Jr (2014) Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids. Proc Natl Acad Sci U S A 111(37):13264–13271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parsons SD, Drewe JA, Gey van Pittius NC, Warren RM, van Helden PD (2013) Novel cause of tuberculosis in meerkats, South Africa. Emerg Infect Dis 19(12):2004–2007

    Article  PubMed  PubMed Central  Google Scholar 

  • Perez E, Samper S, Bordas Y, Guilhot C, Gicquel B, Martin C (2001) An essential role for phoP in Mycobacterium tuberculosis virulence. Mol Microbiol 41(1):179–187

    Article  CAS  PubMed  Google Scholar 

  • Pfyffer GE, Auckenthaler R, van Embden JD, van Soolingen D (1998) Mycobacterium canettii, the smooth variant of M. tuberculosis, isolated from a Swiss patient exposed in Africa. Emerg Infect Dis 4(4):631–634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smith NH (2006) A re-evaluation of M. prototuberculosis. PLoS Pathog 2(9):e98

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith NH, Hewinson RG, Kremer K, Brosch R, Gordon SV (2009a) Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis. Nat Rev Microbiol 7(7):537–544

    Article  CAS  PubMed  Google Scholar 

  • Smith NH, Crawshaw T, Parry J, Birtles RJ (2009b) Mycobacterium microti: More diverse than previously thought. J Clin Microbiol 47(8):2551–2559

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Somoskovi A, Dormandy J, Parsons LM, Kaswa M, Goh KS, Rastogi N, Salfinger M (2007) Sequencing of the pncA gene in members of the Mycobacterium tuberculosis complex has important diagnostic applications: Identification of a species-specific pncA mutation in “Mycobacterium canettii” and the reliable and rapid predictor of pyrazinamide resistance. J Clin Microbiol 45(2):595–599.

    Google Scholar 

  • Somoskovi A, Dormandy J, Mayrer AR, Carter M, Hooper N, Salfinger M (2009) “Mycobacterium canettii” isolated from a human immunodeficiency virus-positive patient: first case recognized in the United States. J Clin Microbiol 47(1):255–257.

    Google Scholar 

  • Supply P, Marceau M, Mangenot S, Roche D, Rouanet C, Khanna V, Majlessi L, Criscuolo A, Tap J, Pawlik A, Fiette L, Orgeur M, Fabre M, Parmentier C, Frigui W, Simeone R, Boritsch EC, Debrie AS, Willery E, Walker D, Quail MA, Ma L, Bouchier C, Salvignol G, Sayes F, Cascioferro A, Seemann T, Barbe V, Locht C, Gutierrez MC, Leclerc C, Bentley SD, Stinear TP, Brisse S, Médigue C, Parkhill J, Cruveiller S, Brosch R (2013) Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet 45:172–179

    Article  CAS  PubMed  Google Scholar 

  • van Ingen J, Rahim Z, Mulder A, Boeree MJ, Simeone R, Brosch R, van Soolingen D (2012) Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies. Emerg Infect Dis 18(4):653–655

    Article  PubMed  PubMed Central  Google Scholar 

  • van Soolingen D, Hoogenboezem T, de Haas PE, Hermans PW, Koedam MA, Teppema KS, Brennan PJ, Besra GS, Portaels F, Top J, Schouls LM, van Embden JD (1997) A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa. Int J Syst Bacteriol 47(4):1236–1245

    Article  PubMed  Google Scholar 

  • van Soolingen D, van der Zanden AG, de Haas PE, Noordhoek GT, Kiers A, Foudraine NA, Portaels F, Kolk AH, Kremer K, van Embden JD (1998) Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers. J Clin Microbiol 36(7):1840–1845

    PubMed  PubMed Central  Google Scholar 

  • Wells AQ (1937) Tuberculosis in wild voles. Lancet 1221

    Google Scholar 

  • Young DB, Comas I, de Carvalho LP (2015) Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis. Front Mol Biosci 2:6

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We are grateful to our colleagues who were involved in the different research projects that are summarized and reviewed in this chapter. Support by grants from the European Union (H2020-PHC-643381), the Agence National de Recherche (ANR-14-JAMR-001-02), the Fondation pour la Recherche Médicale (DEQ20130326471), the Institut Pasteur (PTR 314 and PTR 383), and Genoscope collaborative grant 114 are gratefully acknowledged. P.S. is a consultant for Genoscreen. R.B. is a member of the LabEx consortium IBEID at the Institut Pasteur.

Author information

Authors and Affiliations

  1. Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR 8204 - CIIL - Centre d’Infection et d’Immunité de Lille, F-59000, Lille, France

    Philip Supply

  2. Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, 75724, Paris Cedex 15, France

    Roland Brosch

Authors
  1. Philip Supply
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roland Brosch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roland Brosch .

Editor information

Editors and Affiliations

  1. Swiss Tropical & Public Health Institute, University of Basel, Basel, Switzerland

    Sebastien Gagneux

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Supply, P., Brosch, R. (2017). The Biology and Epidemiology of Mycobacterium canettii . In: Gagneux, S. (eds) Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control. Advances in Experimental Medicine and Biology, vol 1019. Springer, Cham. https://doi.org/10.1007/978-3-319-64371-7_2

Download citation

Publish with us

Policies and ethics

Search

Navigation