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Neurodevelopmental Effects of Serotonin on the Brainstem Respiratory Network

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The Plastic Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1015))

Abstract

Serotonin has multiple roles during development of the nervous system. Human pathologies, mouse genetic models, and pharmacological experiments have demonstrated a role of serotonin in the development of neural networks. Here we summarize evidence showing that serotonin is important for the brainstem respiratory network. The available data highlight the role of serotonin as a developmental signal that previously has not been specifically considered for the respiratory network.

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Abbreviations

5-HT:

5-hydroxytryptamine, serotonin

5-HTergic:

Serotonergic

5-HTP:

5-hydroxytryptophan

5-HTR:

Serotonin receptors

BDNF:

Brain-derived neurotrophic factor

E:

Embryonic day

KO:

Knock out

MAO-A:

Monoamine oxidase A

NTS:

Nucleus tractus solitarii

P:

Postnatal day

PCPA:

Para-chlorophenylalanine

pFRG:

Parafacial respiratory group

preBötC:

preBötzinger complex

RPG:

Respiratory pattern generator

RTN:

Retrotrapezoid nucleus

SERT:

Serotonin transporter

SIDS:

Sudden infant death syndrome

SSRIs:

Selective serotonin reuptake inhibitors

TPH:

Tryptophan hydroxylase

Trp:

Tryptophan

VMAT:

Vesicular monoamine transporter

XII:

Hypoglossal nucleus

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Acknowledgment

Grants Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) # 1171434 (JE) and DICYT-USACH. K. Bravo is a PhD candidate at PhD Program in Neuroscience, Universidad de Santiago de Chile.

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  1. Laboratorio de Sistemas Neurales, Facultad de Química y Biología, Departamento de Biología, Universidad de Santiago de Chile, USACH, PO 9170022, Santiago, Chile

    Karina Bravo PhD, Jaime Eugenín PhD & Isabel Llona PhD

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  1. Pontificia Universidad Católica de Chile, Santiago, Chile

    Rommy von Bernhardi

  2. Universidad de Santiago de Chile, Santiago, Chile

    Jaime Eugenín

  3. University of Miami, Miami, USA

    Kenneth J Muller

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Bravo, K., Eugenín, J., Llona, I. (2017). Neurodevelopmental Effects of Serotonin on the Brainstem Respiratory Network. In: von Bernhardi, R., Eugenín, J., Muller, K. (eds) The Plastic Brain. Advances in Experimental Medicine and Biology, vol 1015. Springer, Cham. https://doi.org/10.1007/978-3-319-62817-2_11

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