Special Aspects of ICU Care: Is There an Art to It?

  • Chapter
  • First Online:
Supportive Care Strategies

Abstract

Intensive care unit (ICU) admission is common following hematopoietic cell transplant, and patients who develop critical illness following transplant experience high mortality. Given the significant potential for morbidity and mortality among critically ill patients who have undergone hematopoietic cell transplant, high-quality supportive care for these patients and their family members is essential. In addition to the key components of supportive care—high-quality communication, symptom control, and emotional and spiritual support—special aspects of supportive care for critically ill patients undergoing transplant warrant consideration. First, high-quality communication between providers of different disciplines must be considered as essential as communication with the patient and family. Second, early involvement of specialty supportive care providers should occur, particularly when symptom management or psychosocial concerns are prominent or the risk of death is very high. Finally, for patients facing death in the ICU, providers should consider several end-of-life care issues unique to this population, including the support of patients and family members as they cope with a major shift in the focus of care, challenges related to maintaining social support networks, and the need to foster closure of the therapeutic relationship with outpatient providers. This chapter will focus on these specific aspects of ICU care for patients who have undergone hematopoietic cell transplant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
EUR 160.49
Price includes VAT (Germany)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Afessa B, Litzow MR, Tefferi A (2001) Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant 28:425–434

    CAS  PubMed  Google Scholar 

  • Afessa B, Tefferi A, Dunn WF et al (2003) Intensive care unit support and Acute Physiology and Chronic Health Evaluation III performance in hematopoietic stem cell transplant recipients. Crit Care Med 31:1715–1721

    PubMed  Google Scholar 

  • Agarwal S, O’Donoghue S, Gowardman J et al (2012) Intensive care unit experience of haemopoietic stem cell transplant patients. Intern Med J 42:748–754

    CAS  PubMed  Google Scholar 

  • Azoulay E, Timsit JF, Sprung CL et al (2009) Prevalence and factors of intensive care unit conflicts: the conflicus study. Am J Respir Crit Care Med 180:853–860

    PubMed  Google Scholar 

  • Back AL, Young JP, McCown E et al (2009) Abandonment at the end of life from patient, caregiver, nurse, and physician perspectives: loss of continuity and lack of closure. Arch Intern Med 169:474–479

    PubMed  PubMed Central  Google Scholar 

  • Bayraktar UD, Nates JL (2016) Intensive care outcomes in adult hematopoietic stem cell transplantation patients. World J Clin Oncol 7:98–105

    PubMed  PubMed Central  Google Scholar 

  • Bayraktar UD, Shpall EJ, Liu P et al (2013) Hematopoietic cell transplantation-specific comorbidity index predicts inpatient mortality and survival in patients who received allogeneic transplantation admitted to the intensive care unit. J Clin Oncol 31:4207–4214

    PubMed  PubMed Central  Google Scholar 

  • Benz R, Schanz U, Maggiorini M et al (2014) Risk factors for ICU admission and ICU survival after allogeneic hematopoietic SCT. Bone Marrow Transplant 49:62–65

    CAS  PubMed  Google Scholar 

  • Bevans MF, Mitchell SA, Barrett JA et al (2014) Symptom distress predicts long-term health and well-being in allogeneic stem cell transplantation survivors. Biol Blood Marrow Transplant 20:387–395

    PubMed  Google Scholar 

  • Boyaci N, Aygencel G, Turkoglu M et al (2014) The intensive care management process in patients with hematopoietic stem cell transplantation and factors affecting their prognosis. Hematology 19:338–345

    PubMed  Google Scholar 

  • Brummel NE, Bell SP, Girard TD et al (2017) Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med 196(1):64–72

    PubMed  PubMed Central  Google Scholar 

  • Button EB, Gavin NC, Keogh SJ (2014) Exploring palliative care provision for recipients of allogeneic hematopoietic stem cell transplantation who relapsed. Oncol Nurs Forum 41:370–381

    PubMed  Google Scholar 

  • Chaudhry HM, Bruce AJ, Wolf RC et al (2016) The incidence and severity of oral mucositis among allogeneic hematopoietic stem cell transplantation patients: a systematic review. Biol Blood Marrow Transplant 22:605–616

    PubMed  Google Scholar 

  • Cohen MZ, Rozmus CL, Mendoza TR et al (2012) Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation. J Pain Symptom Manag 44:168–180

    Google Scholar 

  • Crawford SW, Hackman RC (1993) Clinical course of idiopathic pneumonia after bone marrow transplantation. Am Rev Respir Dis 147:1393–1400

    CAS  PubMed  Google Scholar 

  • Danjoux Meth N, Lawless B, Hawryluck L (2009) Conflicts in the ICU: perspectives of administrators and clinicians. Intensive Care Med 35:2068–2077

    PubMed  Google Scholar 

  • DeKeyser GF, Engelberg R, Torres N et al (2016) Development of a model of interprofessional shared clinical decision making in the ICU: a mixed-methods study. Crit Care Med 44:680–689

    Google Scholar 

  • Drew D, Goodenough B, Maurice L et al (2005) Parental grieving after a child dies from cancer: is stress from stem cell transplant a factor? Int J Palliat Nurs 11:266–273

    PubMed  Google Scholar 

  • Durbin CG Jr (2006) Team model: advocating for the optimal method of care delivery in the intensive care unit. Crit Care Med 34:S12–S17

    PubMed  Google Scholar 

  • El-Jawahri A, LeBlanc T, VanDusen H et al (2016a) Effect of inpatient palliative care on quality of life 2 weeks after hematopoietic stem cell transplantation: a randomized clinical trial. JAMA 316:2094–2103

    PubMed  PubMed Central  Google Scholar 

  • El-Jawahri AR, Vandusen HB, Traeger LN et al (2016b) Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation. Cancer 122:806–812

    PubMed  Google Scholar 

  • Escobar K, Rojas P, Ernst D et al (2015) Admission of hematopoietic cell transplantation patients to the intensive care unit at the Pontificia Universidad Catolica de Chile Hospital. Biol Blood Marrow Transplant 21:176–179

    PubMed  Google Scholar 

  • Fassier T, Azoulay E (2010) Conflicts and communication gaps in the intensive care unit. Curr Opin Crit Care 16:654–665

    PubMed  Google Scholar 

  • Faucher E, Cour M, Jahandiez V et al (2016) Short- and long-term outcomes in onco-hematological patients admitted to the intensive care unit with classic factors of poor prognosis. Oncotarget 7:22427–22438

    PubMed  PubMed Central  Google Scholar 

  • Hashem MD, Nallagangula A, Nalamalapu S et al (2016) Patient outcomes after critical illness: a systematic review of qualitative studies following hospital discharge. Crit Care 20:345

    PubMed  PubMed Central  Google Scholar 

  • Huynh TN, Weigt SS, Belperio JA et al (2009) Outcome and prognostic indicators of patients with hematopoietic stem cell transplants admitted to the intensive care unit. J Transp Secur 2009:917294

    Google Scholar 

  • Iverson E, Celious A, Kennedy CR et al (2014) Factors affecting stress experienced by surrogate decision makers for critically ill patients: implications for nursing practice. Intensive Crit Care Nurs 30:77–85

    PubMed  Google Scholar 

  • Jalmsell L, Onelov E, Steineck G et al (2011) Hematopoietic stem cell transplantation in children with cancer and the risk of long-term psychological morbidity in the bereaved parents. Bone Marrow Transplant 46:1063–1070

    CAS  PubMed  Google Scholar 

  • Kamal AH, Bull JH, Swetz KM et al (2017) Future of the palliative care workforce: preview to an impending crisis. Am J Med 130:113–114

    PubMed  Google Scholar 

  • Kantrow SP, Hackman RC, Boeckh M et al (1997) Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation. Transplantation 63:1079–1086

    CAS  PubMed  Google Scholar 

  • Kew AK, Couban S, Patrick W et al (2006) Outcome of hematopoietic stem cell transplant recipients admitted to the intensive care unit. Biol Blood Marrow Transplant 12:301–305

    PubMed  Google Scholar 

  • Kim MM, Barnato AE, Angus DC et al (2010) The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med 170:369–376

    PubMed  PubMed Central  Google Scholar 

  • Kroschinsky F, Weise M, Illmer T et al (2002) Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies. Intensive Care Med 28:1294–1300

    PubMed  Google Scholar 

  • Lengline E, Chevret S, Moreau AS et al (2015) Changes in intensive care for allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant 50:840–845

    CAS  PubMed  Google Scholar 

  • Lupu D (2010) Estimate of current hospice and palliative medicine physician workforce shortage. J Pain Symptom Manag 40:899–911

    Google Scholar 

  • Martins Pereira S, Teixeira CM, Carvalho AS et al (2016) Compared to palliative care, working in intensive care more than doubles the chances of burnout: results from a Nationwide Comparative Study. PLoS One 11:e0162340

    PubMed  PubMed Central  Google Scholar 

  • Mayer S, Pastores SM, Riedel E et al (2017) Short- and long-term outcomes of adult allogeneic hematopoietic stem cell transplant patients admitted to the intensive care unit in the peritransplant period. Leuk Lymphoma 58:382–390

    PubMed  Google Scholar 

  • McNeese NJ, Khera N, Wordingham SE et al (2016) Team cognition as a means to improve care delivery in critically ill patients with cancer after hematopoietic cell transplantation. J Oncol Pract 12:1091–1099

    PubMed  Google Scholar 

  • Mielcarek M, Storer BE, Flowers ME et al (2007) Outcomes among patients with recurrent high-risk hematologic malignancies after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 13:1160–1168

    PubMed  Google Scholar 

  • Mokart D, Granata A, Crocchiolo R et al (2015) Allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning regimen: outcomes of patients admitted to intensive care unit. J Crit Care 30:1107–1113

    PubMed  Google Scholar 

  • Mosher CE, Redd WH, Rini CM et al (2009) Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: a review of the literature. Psychooncology 18:113–127

    PubMed  PubMed Central  Google Scholar 

  • Odejide OO, Salas Coronado DY, Watts CD et al (2014) End-of-life care for blood cancers: a series of focus groups with hematologic oncologists. J Oncol Pract 10:e396–e403

    PubMed  PubMed Central  Google Scholar 

  • Pallua S, Giesinger J, Oberguggenberger A et al (2010) Impact of GvHD on quality of life in long-term survivors of haematopoietic transplantation. Bone Marrow Transplant 45:1534–1539

    CAS  PubMed  Google Scholar 

  • Paz HL, Crilley P, Weinar M et al (1993) Outcome of patients requiring medical ICU admission following bone marrow transplantation. Chest 104:527–531

    CAS  PubMed  Google Scholar 

  • Pene F, Aubron C, Azoulay E et al (2006) Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports. J Clin Oncol 24:643–649

    PubMed  Google Scholar 

  • Platon L, Amigues L, Ceballos P et al (2016) A reappraisal of ICU and long-term outcome of allogeneic hematopoietic stem cell transplantation patients and reassessment of prognosis factors: results of a 5-year cohort study (2009–2013). Bone Marrow Transplant 51:256–261

    CAS  PubMed  Google Scholar 

  • Price KJ, Thall PF, Kish SK et al (1998) Prognostic indicators for blood and marrow transplant patients admitted to an intensive care unit. Am J Respir Crit Care Med 158:876–884

    CAS  PubMed  Google Scholar 

  • Reeves S, McMillan SE, Kachan N et al (2015) Interprofessional collaboration and family member involvement in intensive care units: emerging themes from a multi-sited ethnography. J Interprof Care 29:230–237

    PubMed  Google Scholar 

  • Roeland E, Ku G (2015) Spanning the canyon between stem cell transplantation and palliative care. Hematology Am Soc Hematol Educ Program 2015:484–489

    PubMed  Google Scholar 

  • Roeland E, Mitchell W, Elia G et al (2010a) Symptom control in stem cell transplantation: a multidisciplinary palliative care team approach. Part 1: physical symptoms. J Support Oncol 8:100–116

    CAS  PubMed  Google Scholar 

  • Roeland E, Mitchell W, Elia G et al (2010b) Symptom control in stem cell transplantation: a multidisciplinary palliative care team approach. Part 2: psychosocial concerns. J Support Oncol 8:179–183

    PubMed  Google Scholar 

  • Saillard C, Blaise D, Mokart D (2016) Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis. Bone Marrow Transplant 51:1050–1061

    CAS  PubMed  Google Scholar 

  • Scales DC, Thiruchelvam D, Kiss A et al (2008) Intensive care outcomes in bone marrow transplant recipients: a population-based cohort analysis. Crit Care 12:R77–R77

    PubMed  PubMed Central  Google Scholar 

  • Soubani AO, Kseibi E, Bander JJ et al (2004) Outcome and prognostic factors of hematopoietic stem cell transplantation recipients admitted to a medical ICU. Chest 126:1604–1611

    PubMed  Google Scholar 

  • Townsend WM, Holroyd A, Pearce R et al (2013) Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning. Br J Haematol 161:578–586

    PubMed  PubMed Central  Google Scholar 

  • Trinkaus MA, Lapinsky SE, Crump M et al (2009) Predictors of mortality in patients undergoing autologous hematopoietic cell transplantation admitted to the intensive care unit. Bone Marrow Transplant 43:411–415

    CAS  PubMed  Google Scholar 

  • Truog RD, Campbell ML, Curtis JR et al (2008) Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care Medicine. Crit Care Med 36:953–963

    PubMed  Google Scholar 

  • Yanik GA, Horowitz MM, Weisdorf DJ et al (2014) Randomized, double-blind, placebo-controlled trial of soluble tumor necrosis factor receptor: enbrel (etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: blood and marrow transplant clinical trials network protocol. Biol Blood Marrow Transplant 20:858–864

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ann C. Long .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Long, A.C. (2020). Special Aspects of ICU Care: Is There an Art to It?. In: Finn, L., Roche Green, A.R. (eds) Supportive Care Strategies. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-59014-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59014-1_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59013-4

  • Online ISBN: 978-3-319-59014-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Navigation