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Contrast Induced Nephropathy

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Cardio-Nephrology

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Abstract

Contrast induced nephropathy continues to be a common cause of acute kidney injury and is associated with significant mortality and morbidity. The pathogenesis involves tubular injury from renal ischemia, reactive oxygen species as well as direct cytotoxic effects of the contrast media. Prevention remains the best option for management of patients at risk. Though multiple strategies have been evaluated, only a few have been shown to be of definite benefit. Novel strategies to reduce contrast volume as well as those targeted at the inflammatory response to tubular ischemia hold promise in being able to reduce nephron loss after dye exposure.

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Author information

Authors and Affiliations

  1. Department of Medicine, Penn Presbyterian Medical Center, Perelman School of Medicine of the University of Pennsylvania, 39th and Market Streets, MOB Suite 240, Philadelphia, PA, 19104, USA

    Michael R. Rudnick

  2. Renal, Electrolyte and Hypertension Division, Department of Medicine, Hospital of University of Pennsylvania, 3400 Spruce Street, Founders 1, Philadelphia, PA, 19104, USA

    Jatinder Kohli

  3. Renal, Electrolytes and Hypertension, Hospital of University of Pennsylvania, 3400 Spruce Stree, Philadelphia, PA, 19104, USA

    Akash N. Sethi

Authors
  1. Jatinder Kohli
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  2. Akash N. Sethi
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  3. Michael R. Rudnick
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Corresponding author

Correspondence to Michael R. Rudnick .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Einstein Medical Center, Sidney Kimmel College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Janani Rangaswami

  2. Department of Medicine, Section of Nephrology, University of Illinois at Chicago, Chicago, Illinois, USA

    Edgar V. Lerma

  3. Department of Nephrology Dialysis and Transplantation, International Renal Research Institute, San Bortolo Hospital, Vicenza, Italy

    Claudio Ronco

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Kohli, J., Sethi, A.N., Rudnick, M.R. (2017). Contrast Induced Nephropathy. In: Rangaswami, J., Lerma, E., Ronco, C. (eds) Cardio-Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-319-56042-7_33

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  • DOI: https://doi.org/10.1007/978-3-319-56042-7_33

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56040-3

  • Online ISBN: 978-3-319-56042-7

  • eBook Packages: MedicineMedicine (R0)

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