Abstract
Animal studies provide a unique opportunity to study the consequences of genetic variants at the behavioural level. Human studies have identified hundreds of risk genes for autism spectrum disorder (ASD) that can lead to understanding on how genetic variation contributes to individual differences in social interaction and stereotyped behaviour in people with ASD. To develop rational therapeutic interventions, systematic animal model studies are needed to understand the relationships between genetic variation, pathogenic processes and the expression of autistic behaviours. Genetic and non-genetic animal model strategies are here reviewed in their propensity to study the underpinnings of behavioural trait variation. We conclude that an integration of reverse and forward genetic approaches may be essential to unravel the neurobiological mechanisms underlying ASD.
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Acknowledgements
This work was supported by EU-AIMS, which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no.115300, resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (P7/2007–2013), from EFPIA companies in kind contribution and from Autism Speaks.
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Molenhuis, R.T., Bruining, H., Kas, M.J. (2017). Modelling Autistic Features in Mice Using Quantitative Genetic Approaches. In: Schmeisser, M., Boeckers, T. (eds) Translational Anatomy and Cell Biology of Autism Spectrum Disorder. Advances in Anatomy, Embryology and Cell Biology, vol 224. Springer, Cham. https://doi.org/10.1007/978-3-319-52498-6_4
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