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Noncoding RNAs in Platelet Biology

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Platelets in Thrombotic and Non-Thrombotic Disorders

Abstract

Noncoding RNAs (ncRNA) account for the majority of the human cellular transcriptome. Advances in sequencing technologies and analytic approaches continue to identify novel ncRNAs. A large amount of research has investigated the role of microRNAs (miRNAs) in megakaryopoiesis and platelet biology, whereas relatively little is known about other ncRNAs. miRNAs affect basic development and physiology by regulating protein translation, and in doing so miRNAs regulate hematopoiesis and megakaryopoiesis. To date, platelet miRNA studies have focused on their use as biomarkers and as tools for understanding basic mechanisms of megakaryocyte/platelet gene expression, but there is a rapidly expanding appreciation for miRNAs as mediators or modifiers of disease, the potential for platelet miRNAs to affect gene expression in other tissues, and as therapeutic targets.

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Authors and Affiliations

  1. The Cardeza Foundation for Hematologic Research and the Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA

    Leonard C. Edelstein Ph.D. & Paul F. Bray M.D.

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  1. Leonard C. Edelstein Ph.D.
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  2. Paul F. Bray M.D.
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Correspondence to Leonard C. Edelstein Ph.D. .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Edelstein, L.C., Bray, P.F. (2017). Noncoding RNAs in Platelet Biology. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_18

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