Abstract
Women who have undergone previous treatment for early breast cancer are at risk of recurrent disease at local or distant sites, as well as the development of new primary breast cancers. Breast imaging improves survival when compared to clinical examination alone. Annual mammography is the routine imaging modality of choice, with MRI and ultrasound reserved for specific populations and problem-solving. Some scenarios such as mammographically occult tumors, imaging the post-mastectomy breast and higher risk groups require specific consideration. Routine imaging to detect distant recurrence in asymptomatic patients is not performed, as this approach has not been shown to improve survival. Future directions, including the roles of tomosynthesis and new imaging strategies to detect distant recurrence and in particular oligometastatic disease are also discussed in this chapter.
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References
Ciatto S, Miccinesi G, Zappa M, Marco Z, Guido M. Prognostic impact of the early detection of metachronous contralateral breast cancer. Eur J Cancer. 2004;40(10):1496–501.
Houssami N, Ciatto S, Martinelli F, Bonardi R, Duffy SW. Early detection of second breast cancers improves prognosis in breast cancer survivors. Ann Oncol. 2009;20(9):1505–10.
Lu W, Schaapveld M, Jansen L, Bagherzadegan E, Sahinovic MM, Baas PC, Hanssen LM, van der Mijle HC, Brandenburg JD, Wiggers T, De Bock GH. The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer. Eur J Cancer. 2009;45(17):3000–7.
Lu WL, Jansen L, Post WJ, Bonnema J, Van de Velde JC, De Bock GH. Impact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysis. Breast Cancer Res Treat. 2009;114(3):403–12.
The London Cancer Alliance. LCA breast cancer clinical guidelines. 2013. Retrieved 12 March 2016. http://www.londoncanceralliance.nhs.uk/media/59178/FINAL%20LCA_BreastGuidelines_231013%20revised%20(3).pdf.
Robertson C, Ragupathy SK, Boachie C, Fraser C, Heys SD, Maclennan G, Mowatt G, Thomas RE, Gilbert FJ, M. S. H. T. A. Group. Surveillance mammography for detecting ipsilateral breast tumour recurrence and metachronous contralateral breast cancer: a systematic review. Eur Radiol. 2011;21(12):2484–91.
Temple LK, Wang EE, McLeod RS. Preventive health care, 1999 update: 3. Follow-up after breast cancer. Canadian Task Force on Preventive Health Care. CMAJ. 1999;161(8):1001–8.
Lewis JL, Tartter PI. The value of mammography within 1 year of conservative surgery for breast cancer. Ann Surg Oncol. 2012;19(10):3218–22.
The Royal College of Radiologists. Guidance on screening and symptomatic breast imaging. 3rd ed. 2013. Retrieved 12 March 2016. https://www.rcr.ac.uk/sites/default/files/publication/BFCR%2813%295_breast.pdf.
Orel SG, Troupin RH, Patterson EA, Fowble BL. Breast cancer recurrence after lumpectomy and irradiation: role of mammography in detection. Radiology. 1992;183(1):201–6.
Günhan-Bilgen I, Oktay A. Mammographic features of local recurrence after conservative surgery and radiation therapy: comparison with that of the primary tumor. Acta Radiol. 2007;48(4):390–7.
Liberman L, Van Zee KJ, Dershaw DD, Morris EA, Abramson AF, Samli B. Mammographic features of local recurrence in women who have undergone breast-conserving therapy for ductal carcinoma in situ. AJR Am J Roentgenol. 1997;168(2):489–93.
Belli P, Costantini M, Romani M, Marano P, Pastore G. Magnetic resonance imaging in breast cancer recurrence. Breast Cancer Res Treat. 2002;73(3):223–35.
Preda L, Villa G, Rizzo S, Bazzi L, Origgi D, Cassano E, Bellomi M. Magnetic resonance mammography in the evaluation of recurrence at the prior lumpectomy site after conservative surgery and radiotherapy. Breast Cancer Res. 2006;8(5):R53.
Robertson C, Arcot Ragupathy SK, Boachie C, Dixon JM, Fraser C, Hernández R, Heys S, Jack W, Kerr GR, Lawrence G, MacLennan G, Maxwell A, McGregor J, Mowatt G, Pinder S, Ternent L, Thomas RE, Vale L, Wilson R, Zhu S, Gilbert FJ. The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer: systematic reviews registry database analyses and economic evaluation. Health Technol Assess. 2011;15(34): v–vi, 1–322.
Heywang-Köbrunner SH, Schlegel A, Beck R, Wendt T, Kellner W, Lommatzsch B, Untch M, Nathrath WB. Contrast-enhanced MRI of the breast after limited surgery and radiation therapy. J Comput Assist Tomogr. 1993;17(6):891–900.
Balu-Maestro C, Bruneton JN, Geoffray A, Chauvel C, Rogopoulos A, Bittman O. Ultrasonographic posttreatment follow-up of breast cancer patients. J Ultrasound Med. 1991;10(1):1–7.
Ciatto S. Detection of breast cancer local recurrences. Ann Oncol. 1995;6 Suppl 2:23–6.
Aichinger U, Schulz-Wendtland R, Krämer S, Lell M, Bautz W. Scar or recurrence—comparison of MRI and color-coded ultrasound with echo signal amplifiers. Rofo. 2002;174(11):1395–401.
Shin JH, Han BK, Choe YH, Nam SJ, Park W, Im YH. Ultrasonographic detection of occult cancer in patients after surgical therapy for breast cancer. J Ultrasound Med. 2005;24(5):643–9.
Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, Pisano ED, Jong RA, Evans WP, Morton MJ, Mahoney MC, Larsen LH, Barr RG, Farria DM, Marques HS, Boparai K, Investigators A. Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA. 2008;299(18):2151–63.
The National Institute for Health and Care Excellence (NICE). 2009. Early and locally advanced breast cancer: diagnosis and treatment. Retrieved 12 March 2016. https://www.nice.org.uk/guidance/cg80/evidence/full-guideline-242201629.
Kuhl CK, Mielcareck P, Klaschik S, Leutner C, Wardelmann E, Gieseke J, Schild HH. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology. 1999;211(1):101–10.
Bluemke DA, Gatsonis CA, Chen MH, DeAngelis GA, DeBruhl N, Harms S, de Boer R, Hillen HF, Roumen RM, Rutten HJ, van der Sangen MJ, Voogd AC. Detection, treatment and outcome of axillary recurrence after axillary clearance for invasive breast cancer. Br J Surg. 2001;88(1):118–22.
Schnall MD, Blume J, Bluemke DA, DeAngelis GA, De Bruhl N, Harms S, Heywang-Köbrunner SH, Hylton N, Kuhl CK, Pisano ED, Causer P, Schnitt SJ, Thickman D, Stelling CB, Weatherall PT, Lehman C, Gatsonis CA. Diagnostic architectural and dynamic features at breast MR imaging: multicenter study. Radiology. 2006;238(1):42–53.
de Boer R, Hillen HF, Roumen RM, et al. Detection, treatment and outcome of axillary recurrence after axillary clearance for invasive breast cancer. Br J Surg. 2001;88:118.
Fajardo LL, Roberts CC, Hunt KR. Mammographic surveillance of breast cancer patients: should the mastectomy site be imaged? AJR Am J Roentgenol. 1993;161(5):953–5.
Pinel-Giroux FM, El Khoury MM, Trop I, Bernier C, David J, Lalonde L. Breast reconstruction: review of surgical methods and spectrum of imaging findings. Radiographics. 2013;33(2):435–53.
Rieber A, Schramm K, Helms G, von Pückler S, Nuessle K, Kreienberg R, Brambs HJ, Kuehn T. Breast-conserving surgery and autogenous tissue reconstruction in patients with breast cancer: efficacy of MRI of the breast in the detection of recurrent disease. Eur Radiol. 2003;13(4):780–7.
Rosselli Del Turco M, Palli D, Cariddi A, Ciatto S, Pacini P, Distante V. Intensive diagnostic follow-up after treatment of primary breast cancer. A randomized trial. National Research Council Project on Breast Cancer follow-up. JAMA. 1994;271(20):1593–7.
Khatcheressian JL, Hurley P, Bantug E, Esserman LJ, Grunfeld E, Halberg F, Hantel A, Henry NL, Muss HB, Smith TJ, Vogel VG, Wolff AC, Somerfield MR, Davidson NE, American Society of Clinical Oncology. Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2013;31(7):961–5.
The Association of Breast Surgery (BASO). 2009 Surgical guidelines for the management of breast cancer. Retrieved 12 March 2016 http://www.associationofbreastsurgery.org.uk/media/4565/surgical_guidelines_for_the_management_of_breast_cancer.pdf.
Shen J, Hunt KK, Mirza NQ, Buchholz TA, Babiera GV, Kuerer HM, Bedrosian I, Ross MI, Ames FC, Feig BW, Singletary SE, Cristofanilli M, Meric-Bernstam F. Predictors of systemic recurrence and disease-specific survival after ipsilateral breast tumor recurrence. Cancer. 2005;104(3):479–90.
The Royal College of Radiologists. 2014. Recommendations for cross-sectional imaging in cancer management. Breast cancer. 2nd ed. Retrieved 12 March 2016. https://www.rcr.ac.uk/sites/default/files/publication/BFCR%2814%292_25_Breast.pdf.
Groheux D, Espié M, Giacchetti S, Hindié E. Performance of FDG PET/CT in the clinical management of breast cancer. Radiology. 2013;266(2):388–405.
Skaane P, Gullien R, Bjørndal H, Eben EB, Ekseth U, Haakenaasen U, Jahr G, Jebsen IN, Krager M. Digital breast tomosynthesis (DBT): initial experience in a clinical setting. Acta Radiol. 2012;53(5):524–9.
Rafferty EA, Park JM, Philpotts LE, Poplack SP, Sumkin JH, Halpern EF, Niklason LT. Assessing radiologist performance using combined digital mammography and breast tomosynthesis compared with digital mammography alone: results of a multicenter, multireader trial. Radiology. 2013;266(1):104–13.
Hakim CM, Chough DM, Ganott MA, Sumkin JH, Zuley ML, Gur D. Digital breast tomosynthesis in the diagnostic environment: A subjective side-by-side review. AJR Am J Roentgenol. 2010;195(2):W172–6.
Zuley ML, Bandos AI, Ganott MA, Sumkin JH, Kelly AE, Catullo VJ, Rathfon GY, Lu AH, Gur D. Digital breast tomosynthesis versus supplemental diagnostic mammographic views for evaluation of noncalcified breast lesions. Radiology. 2013;266(1):89–95.
Andre F, Slimane K, Bachelot T, Dunant A, Namer M, Barrelier A, Kabbaj O, Spano JP, Marsiglia H, Rouzier R, Delaloge S, Spielmann M. Breast cancer with synchronous metastases: trends in survival during a 14-year period. J Clin Oncol. 2004;22(16):3302–8.
Pagani O, Senkus E, Wood W, Colleoni M, Cufer T, Kyriakides S, Costa A, Winer EP, Cardoso F, Force E-MT. International guidelines for management of metastatic breast cancer: can metastatic breast cancer be cured? J Natl Cancer Inst. 2010;102(7):456–63.
Giordano SH, Buzdar AU, Smith TL, Kau SW, Yang Y, Hortobagyi GN. Is breast cancer survival improving? Cancer. 2004;100(1):44–52.
Sawicki LM, Grueneisen J, Schaarschmidt BM, Buchbender C, Nagarajah J, Umutlu L, Antoch G, Kinner S. Evaluation of (18)F-FDG PET/MRI, (18)F-FDG PET/CT, MRI, and CT in whole-body staging of recurrent breast cancer. Eur J Radiol. 2016;85(2):459–65.
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Downey, K., Allen, S. (2016). Detection of Recurrence: Imaging Strategies. In: Ring, A., Parton, M. (eds) Breast Cancer Survivorship. Springer, Cham. https://doi.org/10.1007/978-3-319-41858-2_4
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DOI: https://doi.org/10.1007/978-3-319-41858-2_4
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