Abstract
Recent clinical applications of stem cells have demonstrated novel therapies for chronic diseases and certain kinds of cancers. The first clinical case was treated with hematopoietic stem cells over 50 years ago. Subsequently, mesenchymal stem cells (MSCs) have been clinically applied to various diseases. Furthermore, induced pluripotent stem cells were first clinically used in the last year. Some reports suggest that clinical applications of stem cells will increase from 2017 to 2020. One important requirement for the clinical usage of stem cells is the production of stem cells. The quality of stem cells significantly affects the treatment efficiency. This chapter presents some guidelines for MSC production according to good manufacturing practice (GMP) that helps to maintain the quality of stem cells from batch to batch as well as the clinical satisfaction. Because of the advantages of MSCs, these cells may become the most popular type of stem cells for clinical applications in the near future.
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Van Pham, P., Vu, N.B. (2016). Production of Clinical-Grade Mesenchymal Stem Cells. In: Pham, P. (eds) Stem Cell Processing . Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40073-0_6
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DOI: https://doi.org/10.1007/978-3-319-40073-0_6
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