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The Case of Lipid II: The Achilles’ Heel of Bacteria

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New Weapons to Control Bacterial Growth

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Abstract

This chapter centers on the crucial role that lipid II plays on the bacterial cell wall and its putative role as the Achilles’ heel of pathogenic bacteria. Lipid II is an essential molecule for bacterial survival and biomolecules targeting this compound could interrupt the bacterial cell wall synthesis, hence causing bacterial lysis. We will concentrate here on several lipid II-acting lantibiotics, such as telavancin, vancomycin, and plusbacin. Additionally, human defensins and moenomycins will be also mentioned, as they constitute putative future biomolecules to fight bacterial infections.

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Authors and Affiliations

  1. Department of Microbiology, Biotechnology Unit, Faculty of Pharmacy, University of Santiago de Compostela, Santiago, 15706, Spain

    Tomás G. Villa, Lucía Feijoo-Siota, José Luis R. Rama & Trinidad de Miguel-Bouzas

  2. Discipline of Physiology and Bosch Institute, School of Medical Sciences, University of Sydney, Sydney, NSW, 2006, Australia

    Angeles Sánchez-Pérez

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  1. Tomás G. Villa
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  4. Angeles Sánchez-Pérez
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  5. Trinidad de Miguel-Bouzas
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  1. Faculty of Pharmacy, University of Santiago de Compostel, Santiago de Compostela, Spain

    Tomas G. Villa

  2. Faculty of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain

    Miguel Vinas

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Villa, T.G., Feijoo-Siota, L., Rama, J.L.R., Sánchez-Pérez, A., de Miguel-Bouzas, T. (2016). The Case of Lipid II: The Achilles’ Heel of Bacteria. In: Villa, T., Vinas, M. (eds) New Weapons to Control Bacterial Growth. Springer, Cham. https://doi.org/10.1007/978-3-319-28368-5_9

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