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Liver Function

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

The Long-Evans Cinnamon strain of rats has been recommended as a useful model to study genetically transmitted fulminant hepatitis and chronic liver disease (Yoshida et al. 1987; Hawkins et al. 1995). The underlying cause is thought to be due to excessive copper accumulation in the liver of Long-Evans Cinnamon rats, thus making this animal a model for Wilson’s disease in humans (Okayasu et al. 1992). Chelation therapy or feeding a copper-deficient diet can ameliorate the symptoms in Long-Evans Cinnamon rats and Wilson’s disease (Togashi et al. 1992).

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  1. Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Building H 821, Frankfurt, 65926, Germany

    Andreas W. Herling

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    Franz J. Hock

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Herling, A.W. (2016). Liver Function. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_61

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