Abstract
Addiction to drugs generates modifications in the brain structure and its functions. In this work, an experimental model is described, using rats to characterize the brain activity induced by alcohol addiction. Four records were obtained using electrodes located in brain areas related to impulsivity control and reinforcement, i.e. the prelimbic (PL) and infralimbic (IL) cortex, together with the hippocampus (HPC). In the records, three main events related to the drinking action were selected: in the previous minute (T1), the first minute while drinking (T2) and the first minute after stop** drinking (T3).
In the frequency domain, the normalized energy and coherence were calculated for five bands: delta (2 - 5 Hz), theta (5 - 11 Hz), beta (13 – 30 Hz), slow gamma (35 – 45 Hz) and fast gamma (65 – 90 Hz). Granger causality in the time domain was also computed to obtain the causality relations among different brain areas.
Preliminary results show higher delta activity and higher beta and fast gamma coherence with higher causality values in the limbic channels compared to hippocampus. These results suggest a spectral and synchronization profile among different brain areas, which could lead to obtain parameters able measure the brain activity in case of alcohol addiction.
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© 2014 Springer International Publishing Switzerland
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Guerrero, J. et al. (2014). Brain Activity Characterization Induced by Alcoholic Addiction: Spectral and Causality Analysis of Brain Areas Related to Control and Reinforcement of Impulsivity. In: Roa Romero, L. (eds) XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013. IFMBE Proceedings, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-319-00846-2_419
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DOI: https://doi.org/10.1007/978-3-319-00846-2_419
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-00845-5
Online ISBN: 978-3-319-00846-2
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