Zusammenfassung
Herzinsuffizienz (HF) ist weltweit eine der häufigsten Todesursachen. Zu den häufigsten Erkrankungen, die zu HF mit eingeschränkter Herzkammerfunktion führen, gehören die koronare Herzkrankheit und die nichtischämische (dilatative) Kardiomyopathie. Es besteht ein enormer Bedarf an wirksamen Behandlungen, um geschädigtes Myokard zu reparieren, die Herzfunktion wiederherzustellen und die klinischen Ergebnisse zu verbessern. Als Antwort darauf gab es bedeutende Fortschritte bei der Verwendung natürlicher und synthetischer Biomaterialien mit und ohne Vorläuferzellen, die vielversprechende kardio-reparative Eigenschaften aufweisen. Makrophagen und ihre Monozytenvorläufer scheinen eine entscheidende Rolle bei der Entwicklung, Homöostase und Reparatur von Gewebe zu spielen, da sie in der Lage sind, sich in entzündungshemmende, angiogene und regenerationsfördernde Phänotypen zu polarisieren. In den letzten zehn Jahren haben Forscher herausgefunden, dass bestimmte Biomaterialien die Differenzierung von Monozyten zu Makrophagen fördern, um eine günstige Mikroumgebung für die Geweberegeneration zu schaffen, den gewebespezifischen Umbau zu fördern und als induktive Vorlage für die Reparatur und funktionelle Wiederherstellung verschiedener Organe zu dienen. In diesem Kapitel werden verschiedene Biomaterialien und immuntherapeutische Strategien zur Beeinflussung der Makrophagendifferenzierung für die Reparatur des Herzens vorgestellt.
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Abbreviations
- BMDM:
-
Makrophagen aus dem Knochenmark
- CCL7:
-
C-C-Motiv Chemokin-Ligand 7
- CCL-8:
-
C-C-Motiv Chemokin-Ligand 8
- CABG:
-
Koronare Bypass-Transplantation
- DAMPs:
-
Schädigungs-assoziierte molekulare Muster
- 2DE:
-
Zweidimensionale Elektrophorese
- dECM:
-
Dezellularisierte extrazelluläre Matrix
- DHT:
-
Dehydrothermal
- EDAC:
-
1-(3-(Dimethylamino)propyl)-3-ethylcarbodimid-Hydrochlorid
- ECM:
-
Extrazelluläre Matrix
- ePTFE:
-
Expandiertes Polytetrafluorethylen
- HF:
-
Herzversagen
- HSCs:
-
Hämatopoetische Stammzellen
- IL-1β:
-
Interleukin-1 beta
- LV:
-
Linker Ventrikel
- LVAD:
-
Linksventrikuläres Unterstützungssystem
- MALDI-ToF:
-
Matrix-assisted laser desorption ionization-time of flight-Massenspektrometrie
- MMP:
-
Matrix-Metalloproteinasen
- PAAm:
-
Polyacrylamid
- PAANa:
-
Poly(acrylsäure)
- PCNU:
-
Polycarbonat-Urethan
- PEG:
-
Polyäthylenglykol
- PET:
-
Polyethylenterephthalat
- PLA:
-
Poly(milchsäure)
- PU:
-
Polyurethan
- PU NPs:
-
Polyurethan-Nanopartikel
- TNFα:
-
Tumor-Nekrose-Faktor alpha
- SIS:
-
Dünndarm-Submukosa
- TGF-β1:
-
Transformierender Wachstumsfaktor-beta1
- THP-1:
-
Transformierte menschliche mononukleäre Zelllinie
- UBM:
-
Matrix der Harnblase
- VEGF:
-
Vaskulärer endothelialer Wachstumsfaktor
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Roy, S., Schmuck, E.G., Raval, A.N. (2023). Makrophagen-Reaktion auf Biomaterialien bei kardiovaskulären Anwendungen. In: Haider, K.H. (eds) Stammzellen. Springer, Cham. https://doi.org/10.1007/978-3-031-25378-2_6
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