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Cystic Fibrosis

An Overview

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Airway diseases

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Abstract

Cystic fibrosis (CF) is an inherited disease affecting multiple systems, which can result in progressive lung disease, pancreatic insufficiency, malnutrition, distal intestinal obstruction syndrome, liver dysfunction, and other disorders. In 1938, all children with cystic fibrosis died in infancy, but today the average life expectancy is between 28 and 47.7 years. To optimize short- and long-term outcomes, early diagnosis and treatment by multidisciplinary teams are paramount. Traditional supportive therapies are still crucial in preventing or treating damage to every organ system, and also lately, the introduction of highly effective modulator therapies targeting specific CF transmembrane conductance regulator protein defects resulting from individual genetic mutations has considerably improved the life span and quality and prognosis of CF patients. We hope that this chapter will provide healthcare professionals with an up-to-date assessment of the CF’s pathophysiology, diagnosis, clinical features, and evidence-based new treatments of CF.

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Authors and Affiliations

  1. Department of Pediatric Pulmonology/Ankara-Turkey, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Ebru Yalçın & Uğur Özçelik

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  1. Ebru Yalçın
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  2. Uğur Özçelik
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Correspondence to Ebru Yalçın .

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Editors and Affiliations

  1. Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskisehir, Türkiye

    Cemal Cingi

  2. Department of Pulmonology, Celal Bayar University, Manisa, Türkiye

    Arzu Yorgancıoğlu

  3. Department of Otorhinolaryngology, Kırıkkale University, Kırıkkale, Türkiye

    Nuray Bayar Muluk

  4. Federal University of Bahia School of Medicine and ProAR Foundation, Salvador - Bahia, Brazil

    Alvaro A. Cruz

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  1. Pediatric Pulmonology, Marmara University Faculty of Medicine, Istanbul, Turkey

    Bulent Karadag

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Yalçın, E., Özçelik, U. (2023). Cystic Fibrosis. In: Cingi, C., Yorgancıoğlu, A., Bayar Muluk, N., Cruz, A.A. (eds) Airway diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-22483-6_109-1

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