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Alterations in Cholesterol and Phosphoinositides Levels in the Intracellular Cholesterol Trafficking Disorder NPC

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Cholesterol and PI(4,5)P2 in Vital Biological Functions

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1422))

Abstract

Lipid mistrafficking is a biochemical hallmark of Niemann-Pick Type C (NPC) disease and is classically characterized with endo/lysosomal accumulation of unesterified cholesterol due to genetic mutations in the cholesterol transporter proteins NPC1 and NPC2. Storage of this essential signaling lipid leads to a sequence of downstream events, including oxidative stress, calcium imbalance, neuroinflammation, and progressive neurodegeneration, another hallmark of NPC disease. These observations have been validated in a growing number of studies ranging from NPC cell cultures and animal models to patient specimens. In recent reports, alterations in the levels of another class of critical signaling lipids, namely phosphoinositides, have been described in NPC disease. Focusing on cholesterol and phosphoinositides, the chapter begins by reviewing the interactions of NPC proteins with cholesterol and their role in cholesterol transport. It then continues to describe the modulation of cholesterol efflux in NPC disease. The chapter concludes with a summary of findings related to the functional consequences of perturbations in phosphoinositides in this fatal disease.

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  1. Department of Chemistry, University of Illinois Chicago, Chicago, IL, USA

    Stephanie M. Cologna, Koralege C. Pathmasiri, Melissa R. Pergande & Avia Rosenhouse-Dantsker

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  1. Stephanie M. Cologna
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  2. Koralege C. Pathmasiri
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  3. Melissa R. Pergande
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  4. Avia Rosenhouse-Dantsker
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    Avia Rosenhouse- Dantsker

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Cologna, S.M., Pathmasiri, K.C., Pergande, M.R., Rosenhouse-Dantsker, A. (2023). Alterations in Cholesterol and Phosphoinositides Levels in the Intracellular Cholesterol Trafficking Disorder NPC. In: Dantsker, A.R. (eds) Cholesterol and PI(4,5)P2 in Vital Biological Functions. Advances in Experimental Medicine and Biology, vol 1422. Springer, Cham. https://doi.org/10.1007/978-3-031-21547-6_5

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