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Cardiovascular Autonomic Neuropathy

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Diabetic Neuropathy

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Diabetic neuropathies are the most prevalent chronic complications of diabetes, present with diverse clinical manifestations, and promote high morbidity and mortality, low quality of life, and high health care costs. Among the various forms of diabetic neuropathy, distal symmetric polyneuropathy and diabetic autonomic neuropathies, particularly cardiovascular autonomic neuropathy (CAN), are by far the most studied. Although frequently overlooked in clinical practice due to its characteristic initial very subtle presentation, CAN is quite prevalent in individuals with both type 1 and type 2 diabetes. In addition, high prevalence rates for CAN were reported in several cohorts of individuals with prediabetes/metabolic syndrome and obesity, as well as in youth. Evidence from several large cohorts shows that CAN is an independent predictor of all-cause and cardiovascular mortality as well as of cardiovascular disease risk, including more recently heart failure. Thus, screening for symptoms and signs of CAN is critical in clinical practice as it may be used for risk stratification and to enable early interventions. Although disease modifying therapies for diabetic neuropathy in general including CAN are still lacking, several symptomatic treatment options exist for some forms of CAN.

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Authors and Affiliations

  1. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Lynn Ang & Rodica Pop-Busui

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  1. Lynn Ang
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  2. Rodica Pop-Busui
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Correspondence to Rodica Pop-Busui .

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Editors and Affiliations

  1. Royal Hallamshire Hospital, Sheffield Teaching Hospitals and the University of Sheffield Director of Diabetes Research, Sheffield, UK

    Solomon Tesfaye

  2. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Christopher H. Gibbons

  3. Weill Cornell Medicine, Cornell University, Doha, Qatar

    Rayaz Ahmed Malik

  4. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Aristidis Veves

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Ang, L., Pop-Busui, R. (2023). Cardiovascular Autonomic Neuropathy. In: Tesfaye, S., Gibbons, C.H., Malik, R.A., Veves, A. (eds) Diabetic Neuropathy. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-031-15613-7_12

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  • DOI: https://doi.org/10.1007/978-3-031-15613-7_12

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