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Stress Kinase Signaling in Cardiac Myocytes

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Cardiovascular Signaling in Health and Disease

Abstract

Stress-response kinases, the mitogen-activated protein kinases (MAPKs), are activated in response to the challenge of a myriad of stressors. c-jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and MAPK p38 are the important members of the MAPK family in the heart. Extensive studies have revealed critical roles of activated MAPKs in the processes of cardiac injury, cardiac arrhythmias, heart failure, and other cardiovascular diseases. Advancing our understanding regarding the functional impacts of MAPKs in the development of heart diseases could shed new light on develo** novel therapeutic approaches to improve cardiac function and prevent arrhythmia development in patients. This chapter summarizes relevant current knowledge on the pivotal roles of MAPKs in physiopathological and molecular remodeling in cardiac myocytes during the disease development and for the therapeutic potentials of develo** MAPK inhibitors and/or activators.

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Abbreviations

ASK1-2 :

Apoptosis signal-regulating kinases-1/2

AF :

Atrial fibrillation

BAMBI:

BMP and activin membrane-bound inhibitor

Ca2+-ATPase:

Plasma membrane calcium/calmodulin-dependent ATPase or PMCA

CICR :

Ca2+ induced Ca2+ release

ICa :

Ca2+ influx

CaMKIIδ :

Calcium calmodulin kinase IIδ

Ca2+ :

Calcium

CVDs:

Cardiovascular diseases

CHOP:

C/EBP homologous protein

JNK :

c-jun N-terminal kinase

Cx43 :

Connexin43

CSBP :

Cytokinin-specific binding protein

DAD:

Delayed afterdepolarization

DNMT1 :

DNA methyltransferase-1

DOC-1 :

Downstream-of-CHOP gene1

DWORF :

Dwarf open reading frame

ECC:

Excitation-contraction coupling

ERK:

Extracellular signal-regulated kinase

GSK-3:

Glycogen synthase kinase-3

HF :

Heart failure

HMGB1 :

High mobility group box 1 protein

CRP:

C-reactive protein

[Ca2+]i :

Intracellular Ca2+

I/R :

Ischemia-reperfusion

LTCCs :

L-type Ca2+ channels

MK2 :

MAPKAP kinase-2

Vmax :

Maximal rate

MAPKs :

Mitogen-activated protein kinases

MNK :

Mitogen-activated protein kinase interacting protein kinase

MSK1/2 :

Mitogen and stress-activated protein kinase1/2

MEKK4:

Mitogen-kinase protein kinase kinase kinase-4

MI :

Myocardial infarction

MyBP-C :

Myosin-binding protein C

NCX :

Na+ /Ca2+ exchanger

Ik :

Outward potassium current

PKCε:

Protein kinase Cε

PP1:

Protein phosphatase 1

PLB:

Phospholamban

PAF :

Platelet-activating factor

p70RSK:

p70 ribosomal S6

p90RSK:

p90 ribosomal S6

INa :

Rapid sodium influx

RISK :

Reperfusion injury salvage kinase

RyR2 :

Ryanodine receptor channel-2

SR:

Sarcoplasmic reticulum

SERCA2a:

Sarcoplasmic reticulum Ca2+-ATPase 2a

SPEG :

Striated muscle enriched protein kinase

PTEN:

Tensin homolog on chromosome 10

TNFα-R1:

 Tumor necrosis factor alpha receptor1

TnT:

Troponin T

TGF-β:

Transforming growth factor beta

TAC :

Transverse aortic constriction

T-tubules :

Transverse tubules

TPY :

Threonine-proline-tyrosine phosphorylation motif

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Declarations

This work was supported by National Institutes of Health [P01-HL06426, R01-AA024769, R01-HL113640, R01-HL146744 to XA].

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  1. The Ohio State Univeristy, Physiology and Cell Biology, Columbus, OH, USA

    Xun Ai, Jiajie Yan & Dan J. Bare

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  1. Xun Ai
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  2. Jiajie Yan
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  1. Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Narasimham L. Parinandi

  2. Departments of Biomedical Engineering and Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

    Thomas J. Hund

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Ai, X., Yan, J., Bare, D. (2022). Stress Kinase Signaling in Cardiac Myocytes. In: Parinandi, N.L., Hund, T.J. (eds) Cardiovascular Signaling in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-08309-9_3

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