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Mechanisms of Respiratory Failure

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Manual of Neonatal Respiratory Care

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Abstract

Hypoxemia in the neonatal period can result from multiple causes ventilation/perfusion mismatch, increased physiologic dead space and extrapulmonary (right-to-left) shunts. Hypoventilation (reduced alveolar ventilation, reduction in tidal volume and/or frequency) is distinguished by a high PaCO2 in association with hypoxemia. Reduced lung volume, ventilatory pump failure, increased ventilatory muscle workload and disorders affecting the alveolar-capillary interface can also result in respiratory failure.

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Authors and Affiliations

  1. Women and Children’s Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Anne Greenough & Anthony D. Milner

Authors
  1. Anne Greenough
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  2. Anthony D. Milner
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Correspondence to Anne Greenough .

Editor information

Editors and Affiliations

  1. Division of Neonatal-Perinatal Medicine, C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA

    Steven M. Donn

  2. Division of Neonatology, University of Minnesota, Minneapolis, MN, USA

    Mark C. Mammel

  3. Department of Neonatology, Emma Children’s Hospital Amsterdam UMC University of Amsterdam, Amsterdam, Noord-Holland, The Netherlands

    Anton H.L.C. van Kaam

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Greenough, A., Milner, A.D. (2022). Mechanisms of Respiratory Failure. In: Donn, S.M., Mammel, M.C., van Kaam, A.H. (eds) Manual of Neonatal Respiratory Care. Springer, Cham. https://doi.org/10.1007/978-3-030-93997-7_65

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  • DOI: https://doi.org/10.1007/978-3-030-93997-7_65

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93996-0

  • Online ISBN: 978-3-030-93997-7

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