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Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network

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Coronavirus Therapeutics – Volume I

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1352))

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Abbreviations

ARDS:

Acute Respiratory Distress Syndrome

Covid-19:

Coronavirus Disease of 2019

DMV:

Double Membraned Vesicles

ERAD:

Endoplasmic Reticulum Associated Protein Degradation

ER-UPR:

Endoplasmic Reticulum Unfolded Protein Response

Hsp:

Heat Shock Protein

HSF1:

Heat Shock Factor 1

MERS-CoV:

Middle East Respiratory Syndrome Coronavirus

RdRp:

RNA-dependent RNA polymerase

RT-PCR:

Reverse Transcription-Polymerase Chain Reaction

SARS-CoV-2:

Severe Acute Respiratory Syndrome Coronavirus 2

UPS:

Ubiquitin Proteasome System

References

  • Angelini MM, Akhlaghpour M, Neuman BW, Buchmeier MJ (2013) Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. MBio 4

    Google Scholar 

  • Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC (2005) The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol 79:15189–15198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Batra J, Tripathi S, Kumar A et al (2016) Human heat shock protein 40 (Hsp40/DnaJB1) promotes influenza a virus replication by assisting nuclear import of viral ribonucleoproteins. Sci Rep 6:19063

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bechill J, Chen Z, Brewer JW, Baker SC (2008) Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression. J Virol 82:4492–4501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beigel JH, Tomashek KM, Dodd LE et al (2020) Remdesivir for the treatment of Covid-19 - preliminary report. N Engl J Med

    Google Scholar 

  • Belouzard S, Millet JK, Licitra BN, Whittaker GR (2012) Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses 4:1011–1033

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Benvenuto D, Angeletti S, Giovanetti M et al (2020) Evolutionary analysis of SARS-CoV-2: how mutation of non-structural protein 6 (NSP6) could affect viral autophagy. J Infect 81:e24–e27

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bonam SR, Muller S, Bayry J, Klionsky DJ (2020) Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine. Autophagy

    Google Scholar 

  • Chan CP, Siu KL, Chin KT, Yuen KY, Zheng B, ** DY (2006) Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein. J Virol 80:9279–9287

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen PM, Gombart ZJ, Chen JW (2011) Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration. Cell Biosci 1:10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheng Y, Wong R, Soo YO et al (2005) Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur J Clin Microbiol Infect Dis 24:44–46

    Article  CAS  PubMed  Google Scholar 

  • Chi H, Barry SP, Roth RJ et al (2006) Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A 103:2274–2279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Claverie JM (2020) A putative role of de-mono-ADP-Ribosylation of STAT1 by the SARS-CoV-2 Nsp3 protein in the cytokine storm syndrome of COVID-19. Viruses 12

    Google Scholar 

  • Coronaviridae Study Group of the International Committee on Taxonomy of, V (2020) The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5:536–544

    Article  CAS  Google Scholar 

  • Cottam EM, Whelband MC, Wileman T (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy 10:1426–1441

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Haan CA, Reggiori F (2008) Are nidoviruses hijacking the autophagy machinery? Autophagy 4:276–279

    Article  PubMed  Google Scholar 

  • DeDiego ML, Nieto-Torres JL, Jimenez-Guardeno JM et al (2011) Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. PLoS Pathog 7:e1002315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Delmas B, Laude H (1990) Assembly of coronavirus spike protein into trimers and its role in epitope expression. J Virol 64:5367–5375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deretic V, Saitoh T, Akira S (2013) Autophagy in infection, inflammation and immunity. Nat Rev Immunol 13:722–737

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ding N, Zhao K, Lan Y et al (2017) Induction of atypical autophagy by porcine Hemagglutinating encephalomyelitis virus contributes to viral replication. Front Cell Infect Microbiol 7:56

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Donnelly CA, Ghani AC, Leung GM et al (2003) Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet 361:1761–1766

    Article  PubMed  PubMed Central  Google Scholar 

  • Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM, Bahreini E (2020) A comprehensive review of COVID-19 characteristics. Biol Proced Online 22:19

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fader CM, Colombo MI (2009) Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ 16:70–78

    Article  CAS  PubMed  Google Scholar 

  • Gao G, Luo H (2006) The ubiquitin-proteasome pathway in viral infections. Can J Physiol Pharmacol 84:5–14

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Arencibia M, Hochfeld WE, Toh PP, Rubinsztein DC (2010) Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol 21:691–698

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gassen NC, Niemeyer D, Muth D et al (2019) SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-coronavirus infection. Nat Commun 10:5770

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373–428

    Article  CAS  PubMed  Google Scholar 

  • Gosert R, Kanjanahaluethai A, Egger D, Bienz K, Baker SC (2002) RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J Virol 76:3697–3708

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guo X, Hu H, Chen F et al (2016) iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus. J Proteomics 130:65–75

    Article  CAS  PubMed  Google Scholar 

  • Guo X, Zhang M, Zhang X et al (2017) Porcine epidemic diarrhea virus induces autophagy to benefit its replication. Viruses 9

    Google Scholar 

  • Guo F, Liu X, Cai H, Le W (2018) Autophagy in neurodegenerative diseases: pathogenesis and therapy. Brain Pathol 28:3–13

    Article  CAS  PubMed  Google Scholar 

  • Hamasaki M, Furuta N, Matsuda A et al (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495:389–393

    Article  CAS  PubMed  Google Scholar 

  • Hirayama E, Atagi H, Hiraki A, Kim J (2004) Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex. J Virol 78:1263–1270

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoffmann M, Kleine-Weber H, Schroeder S et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181:271–80 e8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hung IF, Lung KC, Tso EY et al (2020) Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet 395:1695–1704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huotari J, Helenius A (2011) Endosome maturation. EMBO J 30:3481–3500

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hussain S, Pan J, Chen Y et al (2005) Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. J Virol 79:5288–5295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Inoue Y, Tanaka N, Tanaka Y et al (2007) Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J Virol 81:8722–8729

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Isaacson MK, Ploegh HL (2009) Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host Microbe 5:559–570

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Iwasaki A, Yang Y (2020) The potential danger of suboptimal antibody responses in COVID-19. Nat Rev Immunol 20:339–341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiang XS, Tang LY, Dai J et al (2005) Quantitative analysis of severe acute respiratory syndrome (SARS)-associated coronavirus-infected cells using proteomic approaches: implications for cellular responses to virus infection. Mol Cell Proteomics 4:902–913

    Article  CAS  PubMed  Google Scholar 

  • Kahn JS, McIntosh K (2005) History and recent advances in coronavirus discovery. Pediatr Infect Dis J 24:S223–S227. discussion S26

    Article  PubMed  Google Scholar 

  • Kanjanahaluethai A, Chen Z, Jukneliene D, Baker SC (2007) Membrane topology of murine coronavirus replicase nonstructural protein 3. Virology 361:391–401

    Article  CAS  PubMed  Google Scholar 

  • Killerby ME, Biggs HM, Haynes A et al (2018) Human coronavirus circulation in the United States 2014–2017. J Clin Virol 101:52–56

    Article  PubMed  PubMed Central  Google Scholar 

  • Kindrachuk J, Ork B, Hart BJ et al (2015) Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis. Antimicrob Agents Chemother 59:1088–1099

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Knoops K, Kikkert M, Worm SH et al (2008) SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum. PLoS Biol 6:e226

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Korennykh A, Walter P (2012) Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol 28:251–277

    Article  CAS  PubMed  Google Scholar 

  • Krahling V, Stein DA, Spiegel M, Weber F, Muhlberger E (2009) Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. J Virol 83:2298–2309

    Article  PubMed  CAS  Google Scholar 

  • Lamb CA, Yoshimori T, Tooze SA (2013) The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 14:759–774

    Article  CAS  PubMed  Google Scholar 

  • Lan J, Ge J, Yu J et al (2020) Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581:215–220

    Article  CAS  PubMed  Google Scholar 

  • Law HK, Cheung CY, Ng HY et al (2005) Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells. Blood 106:2366–2374

    Article  CAS  PubMed  Google Scholar 

  • Lee YR, Lei HY, Liu MT et al (2008) Autophagic machinery activated by dengue virus enhances virus replication. Virology 374:240–248

    Article  CAS  PubMed  Google Scholar 

  • Liao Y, Fung TS, Huang M, Fang SG, Zhong Y, Liu DX (2013) Upregulation of CHOP/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway. J Virol 87:8124–8134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindner HA, Fotouhi-Ardakani N, Lytvyn V, Lachance P, Sulea T, Menard R (2005) The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme. J Virol 79:15199–15208

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindner HA, Lytvyn V, Qi H, Lachance P, Ziomek E, Menard R (2007) Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease. Arch Biochem Biophys 466:8–14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lipsitch M, Cohen T, Murray M, Levin BR (2007) Antiviral resistance and the control of pandemic influenza. PLoS Med 4:e15

    Article  PubMed  PubMed Central  Google Scholar 

  • Lokugamage KG, Narayanan K, Huang C, Makino S (2012) Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. J Virol 86:13598–13608

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma XZ, Bartczak A, Zhang J et al (2010) Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome. J Virol 84:12419–12428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahase E (2020) Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate. BMJ 368:m641

    Article  PubMed  Google Scholar 

  • Mauthe M, Orhon I, Rocchi C et al (2018) Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy 14:1435–1455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Memish ZA, Al-Tawfiq JA, Assiri A (2013a) Hospital-associated Middle East respiratory syndrome coronavirus infections. N Engl J Med 369:1761–1762

    Article  CAS  PubMed  Google Scholar 

  • Memish ZA, Zumla AI, Assiri A (2013b) Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med 369:884–886

    Article  CAS  PubMed  Google Scholar 

  • Mizushima N, Levine B (2010) Autophagy in mammalian development and differentiation. Nat Cell Biol 12:823–830

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moutzouris JP, Che W, Ramsay EE et al (2010) Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion. Biochim Biophys Acta 1803:416–423

    Article  CAS  PubMed  Google Scholar 

  • Nabar NR, Kehrl JH (2017) The transcription factor EB links cellular stress to the immune response. Yale J Biol Med 90:301–315

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nakagawa K, Lokugamage KG, Makino S (2016) Viral and cellular mRNA translation in coronavirus-infected cells. Adv Virus Res 96:165–192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nal B, Chan C, Kien F et al (2005) Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E. J Gen Virol 86:1423–1434

    Article  CAS  PubMed  Google Scholar 

  • Oostra M, te Lintelo EG, Deijs M, Verheije MH, Rottier PJ, de Haan CA (2007) Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication. J Virol 81:12323–12336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Orenstein SJ, Cuervo AM (2010) Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol 21:719–726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pardo J, Shukla AM, Chamarthi G, Gupte A (2020) The journey of remdesivir: from Ebola to COVID-19. Drugs Context 9

    Google Scholar 

  • Peng Q, Peng R, Yuan B et al (2020) Structural and biochemical characterization of the nsp12-nsp7-nsp8 Core polymerase complex from SARS-CoV-2. Cell Rep 31:107774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phillips AM, Gonzalez LO, Nekongo EE et al (2017) Host proteostasis modulates influenza evolution. Elife 6

    Google Scholar 

  • Phillips AM, Doud MB, Gonzalez LO et al (2018a) Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin. Elife:7

    Google Scholar 

  • Phillips AM, Ponomarenko AI, Chen K et al (2018b) Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones. PLoS Biol 16:e3000008

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR (2004) Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem 279:10136–10141

    Article  CAS  PubMed  Google Scholar 

  • Raaben M, Posthuma CC, Verheije MH et al (2010) The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle. J Virol 84:7869–7879

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramadan N, Shaib H (2019) Middle East respiratory syndrome coronavirus (MERS-CoV): a review. Germs 9:35–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rappe JCF, de Wilde A, Di H et al (2018) Antiviral activity of K22 against members of the order Nidovirales. Virus Res 246:28–34

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reggiori F, Monastyrska I, Verheije MH et al (2010) Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication. Cell Host Microbe 7:500–508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roth-Cross JK, Bender SJ, Weiss SR (2008) Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia. J Virol 82:9829–9838

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sahu R, Kaushik S, Clement CC et al (2011) Microautophagy of cytosolic proteins by late endosomes. Dev Cell 20:131–139

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129–1136

    Article  CAS  PubMed  Google Scholar 

  • Schneider M, Ackermann K, Stuart M et al (2012) Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. J Virol 86:10112–10122

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Settembre C, Di Malta C, Polito VA et al (2011) TFEB links autophagy to lysosomal biogenesis. Science 332:1429–1433

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shi CS, Nabar NR, Huang NN, Kehrl JH (2019) SARS-coronavirus open Reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes. Cell Death Dis 5:101

    Article  CAS  Google Scholar 

  • Snijder EJ, van der Meer Y, Zevenhoven-Dobbe J et al (2006) Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J Virol 80:5927–5940

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stertz S, Reichelt M, Spiegel M et al (2007) The intracellular sites of early replication and budding of SARS-coronavirus. Virology 361:304–315

    Article  CAS  PubMed  Google Scholar 

  • Sun D, Shi H, Guo D et al (2015) Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique. J Virol Methods 218:27–39

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sung SC, Chao CY, Jeng KS, Yang JY, Lai MM (2009) The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6. Virology 387:402–413

    Article  CAS  PubMed  Google Scholar 

  • Tan YJ, Lim SG, Hong W (2006) Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus. Antiviral Res 72:78–88

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Versteeg GA, van de Nes PS, Bredenbeek PJ, Spaan WJ (2007) The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations. J Virol 81:10981–10990

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J (2020) Fast identification of possible drug treatment of coronavirus Disease-19 (COVID-19) through computational drug repurposing study. J Chem Inf Model

    Google Scholar 

  • Wang X, Liao Y, Yap PL, Png KJ, Tam JP, Liu DX (2009) Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol 83:12462–12472

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang X, Cao R, Zhang H et al (2020a) The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov 6:28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Y, Zhang D, Du G et al (2020b) Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 395:1569–1578

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weissman AM (2001) Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2:169–178

    Article  CAS  PubMed  Google Scholar 

  • **a X, Li K, Wu L et al (2020) Improved clinical symptoms and mortality on severe/critical COVID-19 patients utilizing convalescent plasma transfusion. Blood

    Google Scholar 

  • Xu X, Han M, Li T et al (2020) Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A 117:10970–10975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang ZY, Huang Y, Ganesh L et al (2004) pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J Virol 78:5642–5650

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang J, Zheng Y, Gou X et al (2020) Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis 94:91–95

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ye Y, Hauns K, Langland JO, Jacobs BL, Hogue BG (2007) Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist. J Virol 81:2554–2563

    Article  CAS  PubMed  Google Scholar 

  • Yeung YS, Yip CW, Hon CC et al (2008) Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: insights on viral regulation of apoptosis and proliferation. Virology 371:32–43

    Article  CAS  PubMed  Google Scholar 

  • Yu GY, Lai MM (2005) The ubiquitin-proteasome system facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry. J Virol 79:644–648

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yuan W, Liu S, Lu L, Feng J, He X (2020) Clinical interventions for severe and critical COVID-19: what are the options. Am J Transl Res 12:2110–2117

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Z, Thackray LB, Miller BC et al (2007) Coronavirus replication does not require the autophagy gene ATG5. Autophagy 3:581–585

    Article  CAS  PubMed  Google Scholar 

  • Zhao L, Rose KM, Elliott R, Van Rooijen N, Weiss SR (2011) Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol 85:10058–10068

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao L, Jha BK, Wu A et al (2012) Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607–616

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao X, Guo F, Comunale MA et al (2015) Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother 59:206–216

    Article  PubMed  CAS  Google Scholar 

  • Zhou P, Yang XL, Wang XG et al (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579:270–273

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zust R, Cervantes-Barragan L, Habjan M et al (2011) Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol 12:137–143

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

KM acknowledges the funding from Department of Biotechnology (DBT), Government of India, grant number (BT/PR28386/BRB/10/1671/2018) and Science and Engineering Research Board (SERB), Government of India, for Core Research Grant (SERB/CRG/2019/006281) and SNU core funding. PM acknowledges SERB NPDF grant (SERB/F/4161/2018-2019). RS acknowledges ICMR SRF grant (2019-6710/CMB/BMS) and SNU PhD fellowship. MA and MPJ acknowledge SNU PhD fellowship.

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  1. Mudassar Ali and Jyotirmoy Rajurkar contributed equally with all other contributors.

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  1. Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Greater Noida, Uttar Pradesh, India

    Mudassar Ali, Jyotirmoy Rajurkar, Priyanka Majumder, Mainak Pratim Jha, Rajasri Sarkar & Koyeli Mapa

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Ali, M., Rajurkar, J., Majumder, P., Jha, M.P., Sarkar, R., Mapa, K. (2021). Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network. In: Asea, A.A.A., Kaur, P. (eds) Coronavirus Therapeutics – Volume I. Advances in Experimental Medicine and Biology, vol 1352. Springer, Cham. https://doi.org/10.1007/978-3-030-85109-5_8

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