Abstract
Carbon dots (CDs) have gained enormous attention in the class of carbon-based nanomaterials due to their outstanding features, including ultra-small size, hydrophilic nature, low cytotoxicity, and fluorescence, which makes them appropriate for various biomedical applications. Do** of heteroatoms in CDs improves their physicochemical properties, photophysical properties, and quantum yield by their regulatory size, morphology, structure, and energy gap. Do** with metal ions, especially transition metal ions, looks more predominate due to more number of electrons and unoccupied orbitals which make to alter the charge density on the surface of CDs. Furthermore, do** with lanthanide elements provides near-infrared (NIR) response and magnetic activity which are beneficial for NIR-responsive synergistic chemophototherapy and multimodal imaging-guided. Thus, herein we try to provide complete information of metal-doped CDs about their synthetic methods and application in imaging and cancer therapy. At first various synthetic methods for metallic ion doped CDs along with the effects of the reaction parameters and do** on the structure and properties of CDs were discussed. Further, we have broadly explained their applications as bioimaging agents and in the field of cancer phototherapy. Finally, this book chapter will give a promising understanding of various synthesis methods of metal-doped CDs and their biomedical application in both in vitro and in vivo.
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Further Reading
Tejwan N, Saini AK, Sharma A, Singh TA, Kumar N, Das J (2021) Metal-doped and hybrid carbon dots: a comprehensive review on their synthesis and biomedical applications. J Control Release 330:132–150
Lin L, Luo Y, Tsai P, Wang J, Chen X (2018) Metal ions doped carbon quantum dots: synthesis, physicochemical properties, and their applications. TrAC - Trends Anal Chem 103:87–101
Acknowledgments
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2018R1A6A1A03025582).
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Bandi, R., Tummala, S., Dadigala, R., Alle, M., Lee, SH. (2021). Role of Metal-Doped Carbon Dots in Bioimaging and Cancer Therapy. In: Kim, JC., Alle, M., Husen, A. (eds) Smart Nanomaterials in Biomedical Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-84262-8_4
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