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Axial Spine and Sacroiliac Joint

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Regenerative Medicine

Abstract

The use of biologics in the treatment of back pain is gaining rapid popularity due to their potential ability to repair and restore homeostasis. Several autologous and allogenic products are now available, although clinical data supporting their use remain limited. In this chapter, we will discuss the clinical applications of commonly used biologics, with an emphasis on autologous PRP and autologous MSCs. We will focus on their use in the treatment of the most common sources of pain in the lumbar spine, i.e., the intervertebral disks (IVDs), the facet joints, and the sacroiliac (SI) joints.

The objective of this chapter is to provide a basic overview of the available literature, concept, and guidelines for the safe and effective use of biologic therapy in the lumbar spine, with a focus on axial skeleton pain, including intervertebral disks (IVDs), facet joints, and sacroiliac (SI) joints.

We present an initial review of available biologics, as well as the biomechanics of the axial spine, followed by a comprehensive review and analysis of all published clinical studies in the field of regenerative medicine that are relevant to the topics that were reviewed and analyzed.

The discovery of biologics has prompted their consideration for alleviating pain and improving function, as well as for potentially restoring the normal structure of the spine. Additional high-quality studies are needed for deeper insight into the long-term safety and efficacy of regenerative medicine modalities pertinent to the spine.

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Author information

Authors and Affiliations

  1. Comprehensive Spine and Sports Center, Department of Regenerative Medicine, Campbell, CA, USA

    Annu Navani

  2. Comprehensive Spine and Sports Center, Department of Regenerative Medicine and Department of Physical Medicine, Campbell, CA, USA

    Joshua Chrystal

Authors
  1. Annu Navani
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  2. Joshua Chrystal
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Corresponding author

Correspondence to Annu Navani .

Editor information

Editors and Affiliations

  1. Ainsworth Institute of Pain Management, Mount Sinai Hospital Ainsworth Institute of Pain Management, New York, NY, USA

    Corey W Hunter

  2. Source Healthcare and Source Surgery Center, Santa Monica, CA, USA

    Timothy T. Davis

  3. Virginia iSpine Physicians, Richmond, VA, USA

    Michael J. DePalma

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Navani, A., Chrystal, J. (2023). Axial Spine and Sacroiliac Joint. In: Hunter, C.W., Davis, T.T., DePalma, M.J. (eds) Regenerative Medicine . Springer, Cham. https://doi.org/10.1007/978-3-030-75517-1_24

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  • DOI: https://doi.org/10.1007/978-3-030-75517-1_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-75516-4

  • Online ISBN: 978-3-030-75517-1

  • eBook Packages: MedicineMedicine (R0)

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