Use of Maintenance and Resuscitation Fluids

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Cardiopulmonary Monitoring
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Abstract

Administration of intravenous fluids is one of the commonest medical acts in hospitalized patients, but there often is not much thought given to what fluids can and cannot do. Use of fluids should be divided into fluids given to restore daily losses, which we call maintenance needs, versus fluids used for resuscitation of lost fluids or a treatment effect. Use of fluids for daily maintenance requires knowledge of the daily needs of water, Na+, K+, and glucose. Use of fluids for resuscitation needs to consider restoration of the body’s natural reserves, which are the unstressed vascular volume and the interstitial volume, as well as the use of fluids to expand stressed vascular with the purpose of increasing cardiac output. Discussion also is given to the effects of different kinds of fluids and the limits of the therapeutic use of fluids.

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Notes

  1. 1.

    A mole indicates the amount of a substance but what is important in chemical reactions is how much the substance reacts, which is called equivalents. The values are close but equivalents are actually measured and the values reported in tests. mEq is 1000th of an equivalent.

References

  • Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581–9.

    Article  PubMed  Google Scholar 

  • Ayus JC, Krothapalli RK, Arieff AI. Treatment of symptomatic hyponatremia and its relation to brain damage. A prospective study. N Engl J Med. 1987;317(19):1190–5.

    Article  CAS  PubMed  Google Scholar 

  • Bafaqeeh F, Magder S. CVP and volume responsiveness of cardiac output. Am J Respir Crit Care Med. 2004;169(7):A344.

    Google Scholar 

  • Bhave G, Neilson EG. Body fluid dynamics: back to the future. J Am Soc Nephrol. 2011;22(12):2166–81.

    Article  CAS  PubMed  Google Scholar 

  • Bihari S, Ou J, Holt AW, Bersten AD. Inadvertent sodium loading in critically ill patients. Crit Care Resusc. 2012;14(1):33–7.

    PubMed  Google Scholar 

  • Bihari S, Peake SL, Seppelt I, Williams P, Bersten A. Sodium administration in critically ill patients in Australia and New Zealand: a multicentre point prevalence study. Crit Care Resusc. 2013;15(4):294–300.

    PubMed  Google Scholar 

  • Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011;39(2):259–65.

    Article  PubMed  Google Scholar 

  • Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125–39.

    Article  CAS  PubMed  Google Scholar 

  • Caldini P, Permutt S, Waddell JA, Riley RL. Effect of epinephrine on pressure, flow, and volume relationships in the systemic circulation of dogs. Circ Res. 1974;34:606–23.

    Article  CAS  PubMed  Google Scholar 

  • Charron C, Caille V, Jardin F, Vieillard-Baron A. Echocardiographic measurement of fluid responsiveness. Curr Opin Crit Care. 2006;12(3):249–54.

    Article  PubMed  Google Scholar 

  • Chowdhury AH, Lobo DN. Fluids and gastrointestinal function. Curr Opin Clin Nutr Metab Care. 2011;14(5):469–76.

    Article  PubMed  Google Scholar 

  • Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte(R) 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Ann Surg. 2012;256(1):18–24.

    Article  PubMed  Google Scholar 

  • Deschamps A, Magder S. Baroreflex control of regional capacitance and blood flow distribution with or without alpha adrenergic blockade. J Appl Physiol. 1992;263:H1755–H63.

    CAS  Google Scholar 

  • Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350(22):2247–56.

    Article  CAS  PubMed  Google Scholar 

  • Fortes MB, Owen JA, Raymond-Barker P, Bishop C, Elghenzai S, Oliver SJ, et al. Is this elderly patient dehydrated? Diagnostic accuracy of hydration assessment using physical signs, urine, and saliva markers. J Am Med Dir Assoc. 2015;16(3):221–8.

    Article  PubMed  Google Scholar 

  • Gomez-Izquierdo JC, Trainito A, Mirzakandov D, Stein BL, Liberman S, Charlebois P, et al. Goal-directed fluid therapy does not reduce primary postoperative ileus after elective laparoscopic colorectal surgery: a randomized controlled trial. Anesthesiology. 2017;127(1):36–49.

    Article  PubMed  Google Scholar 

  • Gorelick MH, Shaw KN, Murphy KO. Validity and reliability of clinical signs in the diagnosis of dehydration in children. Pediatrics. 1997;99(5):E6.

    Article  CAS  PubMed  Google Scholar 

  • Halberthal M, Halperin ML, Bohn D. Lesson of the week: acute hyponatraemia in children admitted to hospital: retrospective analysis of factors contributing to its development and resolution. BMJ. 2001;322(7289):780–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hamilton-Davies C, Mythen MD, Salmon JB, Jacobson D, Shukla A, Webb AR. Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry. Intensive Care Med. 1997;23:276–81.

    Article  CAS  PubMed  Google Scholar 

  • Hjortrup PB, Haase N, Bundgaard H, Thomsen SL, Winding R, Pettilä V, et al. Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel-group, multicentre feasibility trial. Intensive Care Med. 2016;42(11):1695–705.

    Article  PubMed  Google Scholar 

  • Hooper L, Abdelhamid A, Attreed NJ, Campbell WW, Channell AM, Chassagne P, et al. Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people. Cochrane Database Syst Rev. 2015;(4).

    Google Scholar 

  • Kellum JA, Shaw AD. Assessing toxicity of intravenous crystalloids in critically ill patients. JAMA. 2015;314(16):1695–7.

    Article  PubMed  Google Scholar 

  • Kellum JA, Bellomo R, Kramer DJ, Pinsky MR. Etiology of metabolic acidosis during saline resuscitation in endotoxemia. Shock. 1998;9(5):364–8.

    Article  CAS  PubMed  Google Scholar 

  • Kelm DJ, Perrin JT, Cartin-Ceba R, Gajic O, Schenck L, Kennedy CC. Fluid overload in patients with severe sepsis and septic shock treated with early goal-directed therapy is associated with increased acute need for fluid-related medical interventions and hospital death. Shock. 2015;43(1):68–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khajavi MR, Etezadi F, Moharari RS, Imani F, Meysamie AP, Khashayar P, et al. Effects of normal saline vs. lactated ringer’s during renal transplantation. Ren Fail. 2008;30(5):535–9.

    Article  CAS  PubMed  Google Scholar 

  • Laron Z. Skin turgor as a quantitative index of dehydration in children. Pediatrics. 1957;19(5):816–22.

    Article  CAS  PubMed  Google Scholar 

  • Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010;87(2):198–210.

    Article  CAS  PubMed  Google Scholar 

  • Long CL, Kinney JM, Geiger JW. Nonsuppressability of gluconeogenesis by glucose in septic patients. Metabolism. 1976;25(2):193–201.

    Article  CAS  PubMed  Google Scholar 

  • Magder S. Balanced versus unbalanced salt solutions: what difference does it make? Best Pract Res Clin Anaesthesiol. 2014;28:235–47.

    Article  PubMed  Google Scholar 

  • Magder S, De Varennes B. Clinical death and the measurement of stressed vascular volume. Crit Care Med. 1998;26:1061–4.

    Article  CAS  PubMed  Google Scholar 

  • Magder S, Emami A. Practical approach to physical-chemical acid-base management. Stewart at the bedside. Ann Am Thorac Soc. 2015;12(1):111–7.

    Article  PubMed  Google Scholar 

  • Magder S, Vanelli G. Circuit factors in the high cardiac output of sepsis. J Crit Care. 1996;111(4):155–66.

    Article  Google Scholar 

  • Magder SA, Georgiadis G, Cheong T. Respiratory variations in right atrial pressure predict response to fluid challenge. J Crit Care. 1992;7:76–85.

    Article  Google Scholar 

  • Magder S, Potter BJ, Varennes BD, Doucette S, Fergusson D. Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med. 2010;38(11):2117–24.

    Article  PubMed  Google Scholar 

  • Mange K, Matsuura D, Cizman B, et al. Language guiding therapy: the case of dehydration versus volume depletion. Ann Intern Med. 1997;127(9):848–53.

    Article  CAS  PubMed  Google Scholar 

  • Martin GS, Moss M, Wheeler AP, Mealer M, Morris JA, Bernard GR. A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med. 2005;33(8):1681–7.

    Article  CAS  PubMed  Google Scholar 

  • McCluskey SA, Karkouti K, Wijeysundera D, Minkovich L, Tait G, Beattie WS. Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study. Anesth Analg. 2013;117(2):412–21.

    Article  PubMed  Google Scholar 

  • McGee S, Abernethy WB III, Simel DL. Is this patient hypovolemic? J Am Med Assoc. 1999;281(11):1022–9.

    Article  CAS  Google Scholar 

  • McNab S. Intravenous maintenance fluid therapy in children. J Paediatr Child Health. 2016;52(2):137–40.

    Article  PubMed  Google Scholar 

  • Mellander S, Johansson B. Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol Rev.: The Williams & Wilkins Co. 1968;20:117–96.

    CAS  PubMed  Google Scholar 

  • Michel CC. Starling: the formulation of his hypothesis of microvascular fluid exchange and its significance after 100 years. Exp Physiol. 1997;82(1):1–30.

    Article  CAS  PubMed  Google Scholar 

  • Mitzner W, Goldberg H. Effects of epinephrine on resistive and compliant properties of the canine vasculature. J Appl Physiol. 1975;39(2):272–80.

    Article  CAS  PubMed  Google Scholar 

  • Monnet X, Rienzo M, Osman D, Anguel N, Richard C, Pinsky MR, et al. Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med. 2006;34(5):1402–7.

    Article  PubMed  Google Scholar 

  • Moretti EW, Robertson KM, El-Moalem H, Gan TJ. Intraoperative colloid administration reduces postoperative nausea and vomiting and improves postoperative outcomes compared with crystalloid administration. Anesth Analg. 2003;96(611):617.

    Google Scholar 

  • Moritz ML, Ayus JC. Maintenance intravenous fluids in acutely ill patients. N Engl J Med. 2015;373(14):1350–60.

    Article  PubMed  Google Scholar 

  • Myburgh J, Cooper DJ, Finfer S, Bellomo R, Norton R, Bishop N, et al. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med. 2007;357(9):874–84.

    Article  CAS  PubMed  Google Scholar 

  • Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012;367(20):1901–11.

    Article  CAS  PubMed  Google Scholar 

  • Nanas S, Magder S. Adaptations of the peripheral circulation to PEEP. Am Rev Respir Dis. 1992;146:688–93.

    Article  CAS  PubMed  Google Scholar 

  • O’Malley CM, Frumento RJ, Hardy MA, Benvenisty AI, Brentjens TE, Mercer JS, et al. A randomized, double-blind comparison of lactated Ringer’s solution and 0.9% NaCl during renal transplantation. Anesth Analg. 2005;100(5):1518–24, table.

    Article  PubMed  CAS  Google Scholar 

  • Offringa M. Excess mortality after human albumin administration in critically ill patients. BMJ. 1998;317:223–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, et al. Hydroxyethyl starch 130/0.4 versus ringer’s acetate in severe sepsis. N Engl J Med. 2012;367:124–34.

    Article  CAS  PubMed  Google Scholar 

  • Pitts RF. Renal regulation of acid-base balance. In: Robert FP, editor. Physiology of the kidney and body fluids. 2nd ed. Chicago: Year Book Medical Publishers Incorporated; 1968. p. 179–212.

    Google Scholar 

  • Rothe C. Venous system: physiology of the capacitance vessels. In: Shepherd JT, Abboud FM, editors. Handbook of physiology. The cardiovascular system. Section 2. III. Bethesda: American Physiological Society; 1983a. p. 397–452.

    Google Scholar 

  • Rothe CF. Reflex control of veins and vascular capacitance. Physiol Rev. 1983b;63(4):1281–95.

    Article  CAS  PubMed  Google Scholar 

  • Santry HP, Alam HB. Fluid resuscitation: past, present, and the future. Shock. 2010;33(3):229–41.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sartorius OW, Roemmelt JC, Pitts RF. The renal regulation of acid-base balance in man; the nature of the renal compensations in ammonium chloride acidosis. J Clin Invest. 1949;28(3):423–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schricker T, Lattermann R, Carli F. Intraoperative protein sparing with glucose. J Appl Physiol (1985). 2005;99(3):898–901.

    Article  CAS  Google Scholar 

  • Shaw AD, Bagshaw SM, Goldstein SL, Scherer LA, Duan M, Schermer CR, et al. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg. 2012;255(5):821–9.

    Article  PubMed  Google Scholar 

  • Shaw AD, Schermer CR, Lobo DN, Munson SH, Khangulov V, Hayashida DK, et al. Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care. 2015;19:334.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sort P, Navasa M, Arroyo V, Aldeguer X, Planas R, Ruiz-del-Arbol L, et al. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med. 1999;341:403–9.

    Article  CAS  PubMed  Google Scholar 

  • Traverso LW, Lee WP, Langford MJ. Fluid resuscitation after an otherwise fatal hemorrhage: I. Crystalloid solutions. J Trauma. 1986;26(2):168–75.

    Article  CAS  PubMed  Google Scholar 

  • Tredget EE, Burke JF. In: Clowes Jr GHA, editor. Calorie and substrate requirements in trauma and sepsis. New York: Marcel Dekker, Inc; 1988.

    Google Scholar 

  • Treib J, Baron JF, Grauer MT, Strauss RG. An international view of hydroxyethyl starches. Intensive Care Med. 1999;25(3):258–68.

    Article  CAS  PubMed  Google Scholar 

  • Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34(2):344–53.

    Article  PubMed  Google Scholar 

  • Vivanti A, Harvey K, Ash S, Battistutta D. Clinical assessment of dehydration in older people admitted to hospital: what are the strongest indicators? Arch Gerontol Geriatr. 2008;47(3):340–55.

    Article  PubMed  Google Scholar 

  • Weiner ID, Verlander JW. Renal ammonia metabolism and transport. Compr Physiol. 2013;3(1):201–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, de Boisblanc B, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354(24):2564–75.

    Article  CAS  PubMed  Google Scholar 

  • Wiedermann CJ, Joannidis M. The Boldt scandal still in need of action: the example of colloids 10 years after initial suspicion of fraud. Intensive Care Med. 2018;44(10):1735–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu BU, Hwang JQ, Gardner TH, Repas K, Delee R, Yu S, et al. Lactated Ringer’s solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011;9(8):710–7.

    Article  PubMed  Google Scholar 

  • Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA. 2015;314(16):1701–10.

    Article  CAS  PubMed  Google Scholar 

  • Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. J Am Med Assoc. 2012;308(15):1566–72.

    Article  CAS  Google Scholar 

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Magder, S. (2021). Use of Maintenance and Resuscitation Fluids. In: Magder, S., Malhotra, A., Hibbert, K.A., Hardin, C.C. (eds) Cardiopulmonary Monitoring. Springer, Cham. https://doi.org/10.1007/978-3-030-73387-2_42

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