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Nasopharyngeal Carcinoma

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Pediatric Surgical Oncology

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Abstract

Nasopharyngeal carcinoma (NPC) is a relatively rare tumor in the pediatric population, accounting for less than 1% of all pediatric malignancies. Most prevalent in teenagers than in children under 10 years of age, NPC is also highly related to the Epstein-Barr virus (EBV). NPC initially presents with nonspecific signs and symptoms such as nasal congestion, epistaxis, and/or headaches in a previously healthy child. Due to its nonspecific presenting signs, NPC is often diagnosed at a loco-regionally advanced stage in the pediatric and adolescent populations. However, it carries a better prognosis in children than in adults, with a 5-year overall survival reportedly close to 90%. NPC is sensitive to chemotherapy and radiation therapy, and concurrent chemoradiotherapy with or without neoadjuvant chemotherapy is considered as the first-line treatment in children, while surgery is only recommended for recurrences or nonresponding cases.

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Authors and Affiliations

  1. Division of Pediatric Oncological Otolaryngology Head and Neck Surgery, Health Science Center Department of Otolaryngology, University of Tennessee, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Celine Richard & Anthony Sheyn

Authors
  1. Celine Richard
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  2. Anthony Sheyn
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Correspondence to Anthony Sheyn .

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Editors and Affiliations

  1. University of Oxford, Oxford, UK

    Kokila Lakhoo

  2. St. Jude Children's Research Hospital, Memphis, TN, USA

    Abdelhafeez H. Abdelhafeez

  3. Federal University of Sao Paulo, Sao Paulo, Brazil

    Simone Abib

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Richard, C., Sheyn, A. (2022). Nasopharyngeal Carcinoma. In: Lakhoo, K., Abdelhafeez, A.H., Abib, S. (eds) Pediatric Surgical Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-71113-9_105-1

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  • DOI: https://doi.org/10.1007/978-3-030-71113-9_105-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-71113-9

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