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Colliguaja integerrima Gillies & Hook.

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Medicinal and Aromatic Plants of South America Vol. 2

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 7))

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Abstract

Colliguaja integerrima Gillies & Hook. (Euphorbiaceae) is an evergreen shrub native to Argentina and Chile, widely distributed in the Patagonia region. Tehuelches-Mapuches, the native people of Patagonia, have used this abundant plant to treat corns, warts and toothache and used the “colihuai” latex from the leaves and young branches, considered very poisonous, to poison their spearheads and arrowheads. Also, these were used as plasters for their analgesic properties. A decoction of the plant was used by Tehuelches for vaginal infections.

Carbohydrates (polysaccharides with glucose, galactose, sulfate groups and pinitol), proteins, lipids (containing ricinoleic acid), flavonoids (datiscetin, kaempferol, pelargonidin and delfinidin), tannins, steroids and triterpenes (betulin) are the principal compounds. The chemical composition of this plant and the demonstrated antibacterial and antioxidant activities are evidences that could broadly support the traditional use. Methanolic and aqueous extracts evidenced important cytotoxicity against Artemia salina. The dichloromethane fraction, rich in betulin, generated 100% inhibition (at 100μg/ml) against promastigotes of Leishmania donovani (causal of visceral leishmaniasis). In view of its background in traditional medicine, this chapter reviews scientific studies on the chemical and biological properties of this species.

figure a

Colliguaja integerrima Gillies & Hook. in its habitat (Comodoro Rivadavia, Chubut, Argentina). Photo: ML Flores and OL Córdoba

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Acknowledgments

We are especially grateful to the ChemBioFight IRSES Project, UNPSJB and FONCYT Argentina, for financial support. DPQ and MSN are supported by CONICET and CIN, respectively.

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Authors and Affiliations

  1. Centro Regional de Investigación y Desarrollo Científico Tecnológico (CRIDECIT), Departamento de Farmacia, Facultad de Ciencias Naturales y Ciencias de la Salud (FCNyCS), Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB), Comodoro Rivadavia, Chubut, Argentina

    Graciela Pinto Vitorino, Diana Paula Quezada, María Soledad Namuncurá, Osvaldo León Córdoba & María Luján Flores

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  1. Graciela Pinto Vitorino
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  2. Diana Paula Quezada
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  3. María Soledad Namuncurá
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  4. Osvaldo León Córdoba
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  5. María Luján Flores
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Corresponding author

Correspondence to María Luján Flores .

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Editors and Affiliations

  1. Faculty of Agr. & Food Sc., Széchenyi István University, Mosonmagyaróvár, Hungary

    Ákos Máthé

  2. Facultad de Farmacia y Bioquímica, Farmacognosia, Universidad de Buenos Aires, Buenos Aires, Argentina

    Arnaldo Bandoni

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Pinto Vitorino, G., Quezada, D.P., Namuncurá, M.S., Córdoba, O.L., Flores, M.L. (2021). Colliguaja integerrima Gillies & Hook.. In: Máthé, Á., Bandoni, A. (eds) Medicinal and Aromatic Plants of South America Vol. 2. Medicinal and Aromatic Plants of the World, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-62818-5_12

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