Amoxapine and Depressions

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NeuroPsychopharmacotherapy

Abstract

Amoxapine is a tricyclic antidepressant (TCA) and used in the treatment of major depressive disorder. It is a norepinephrine and serotonin reuptake inhibitor. A more rapid onset of action is discussed in comparison to other antidepressants. There are notable, especially anticholinergic, side effects such as constipation and paralytic ileus, urinary retention, and ECG changes. Amoxapine is potentially lethal when overdosed.

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References

  • Apiquian R, Fresan A, Ulloa RE, de la Fuente-Sandoval C, Herrera-Estrella M, Vazquez A, Nicolini H, Kapur S. Amoxapine as an atypical antipsychotic: a comparative study vs risperidone. Neuropsychopharmacology. 2005;30:2236–44.

    Article  CAS  PubMed  Google Scholar 

  • Ban TA, Wilson WH, McEvoy JP. Amoxapine: a review of literature. Int Pharmacopsychiatry. 1980;15:166–70.

    Article  CAS  PubMed  Google Scholar 

  • Buckley NA, McManus PR. Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data? Drug Saf. 1998;18:369–81.

    Article  CAS  PubMed  Google Scholar 

  • Chaudhry IB, Husain N, Khan S, Badshah S, Deakin B, Kapur S. Amoxapine as an antipsychotic: comparative study versus haloperidol. J Clin Psychopharmacol. 2007;27:575–81.

    Article  CAS  PubMed  Google Scholar 

  • Davis JM, Wang Z, Janicak PG. A quantitative analysis of clinical drug trials for the treatment of affective disorders. Psychopharmacol Bull. 1993;29:175–81.

    CAS  PubMed  Google Scholar 

  • Drugbank.ca. https://www.drugbank.ca/drugs/DB00543. Accessed 12 Nov 2019.

  • Fitzgerald PB, Filia S, De Castella A, McBain N, Kapur S, Kulkarni J. Amoxapine in schizophrenia: a negative double-blind controlled trial. J Clin Psychopharmacol. 2004;24:448–50.

    PubMed  Google Scholar 

  • Food and Drug Administration (FDA). https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/072691s036lbl.pdf. Accessed 16 Dec 2018.

  • Fruensgaard K, Hansen CE, Korsgaard S, Nymgaard K, Vaag UH. Amoxapine versus amitriptyline in endogenous depression. A double-blind study. Acta Psychiatr Scand. 1979;59:502–8.

    Article  CAS  PubMed  Google Scholar 

  • Hekimian LJ, Friedhoff AJ, Deever E. A comparison of the onset of action and therapeutic efficacy of amoxapine and amitriptyline. J Clin Psychiatry. 1978;39:633–7.

    CAS  PubMed  Google Scholar 

  • Jue SG, Dawson GW, Brogden RN. Amoxapine: a review of its pharmacology and efficacy in depressed states. Drugs. 1982;24:1–23.

    Article  CAS  PubMed  Google Scholar 

  • Kapur S, Cho R, Jones C, McKay G, Zipursky RB. Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy. Biol Psychiatry. 1999;45:1217–20.

    Article  CAS  PubMed  Google Scholar 

  • Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE. PubChem 2019 update: improved access to chemical data. Nucleic Acids Res. 2019;47(D1):D1102–9.

    Google Scholar 

  • Kinney JL, Evans RL Jr. Evaluation of amoxapine. Clin Pharm. 1982;1:417–24.

    CAS  PubMed  Google Scholar 

  • Neuroscience based Nomenclature. http://www.nbn2.com/search#drug/6. Accessed 14 Dec 2018.

  • Stahl SM. Prescriber’s guide. 6th ed. Cambridge, MA: Cambridge University Press; 2017.

    Google Scholar 

  • Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997;11:249–58.

    Article  Google Scholar 

  • Uptodate.com. Accessed 14 Dec 2018.

    Google Scholar 

  • White N, Litovitz T, Clancy C. Suicidal antidepressant overdoses: a comparative analysis by antidepressant type. J Med Toxicol. 2008;4:238–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Winek CL, Wahba WW, Rozin L. Amoxapine fatalities: three case studies. Forensic Sci Int. 1984;26:33–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Dan Rujescu .

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Rujescu, D., Röttig, S., Krause, T.J. (2022). Amoxapine and Depressions. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-030-62059-2_82

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  • DOI: https://doi.org/10.1007/978-3-030-62059-2_82

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-62058-5

  • Online ISBN: 978-3-030-62059-2

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