Abstract
The resting state paradigm is ubiquitous in clinical neuroimaging, being convenient and practical to run, and yielding robust and theoretically salient individual differences in functional connectivity. The richness of the data, and the consequential variety of analyses that can be performed is both a blessing and a curse, providing many potential leads but few decisive observations. The problems of this complexity are compounded when the method is applied to multidimensional phenotypes such as mood disorders. In particular, I explore several potential accounts of the nature of the underlying alteration(s) of functional connectivity in major depression, including structural deficits, Hebbian mechanisms, mood and arousal-related alterations and neurotransmitter-based mechanisms. Evidence for and against each mechanism is described, with methodological heterogeneity and state-related factors being emphasized as areas of particular significance for future work. In summary, I describe the considerable progress that has been made, outlining the many challenges but also successful attempts to make progress toward the goal of identifying replicable and generalizable markers of major depression.
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References
Abrol, A., Chaze, C., Damaraju, E., & Calhoun, V. D. (2016). The chronnectome: Evaluating replicability of dynamic connectivity patterns in 7500 resting fMRI datasets. Conf Proc IEEE Eng Med Biol Soc, 2016, 5571–5574. doi: https://doi.org/10.1109/EMBC.2016.7591989
Admon, R., & Pizzagalli, D. A. (2015). Corticostriatal pathways contribute to the natural time course of positive mood. Nat Commun, 6, 10065. doi: https://doi.org/10.1038/ncomms10065
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., . . . Lowe, M. J. (2005). Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry, 57, 1079–1088. doi: https://doi.org/10.1016/j.biopsych.2005.02.021
Andrews-Hanna, J. R., Reidler, J. S., Huang, C., & Buckner, R. L. (2010). Evidence for the default network’s role in spontaneous cognition. J Neurophysiol, 104, 322–335. doi: https://doi.org/10.1152/jn.00830.2009 jn.00830.2009 [pii]
Baria, A. T., Mansour, A., Huang, L., Baliki, M. N., Cecchi, G. A., Mesulam, M. M., & Apkarian, A. V. (2013). Linking human brain local activity fluctuations to structural and functional network architectures. Neuroimage, 73, 144–155. doi: https://doi.org/10.1016/j.neuroimage.2013.01.072 S1053-8119(13)00119-5 [pii]
Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Boorman, E., P, M. M., & P, J. C. (2008). Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. Int J Neuropsychopharmacol, 11, 255–260. doi: https://doi.org/10.1017/S1461145707007924
Bijsterbosch, J., Harrison, S., Duff, E., Alfaro-Almagro, F., Woolrich, M., & Smith, S. (2017). Investigations into within- and between-subject resting-state amplitude variations. Neuroimage, 159, 57–69. doi: https://doi.org/10.1016/j.neuroimage.2017.07.014
Birn, R. M., Cornejo, M. D., Molloy, E. K., Patriat, R., Meier, T. B., Kirk, G. R., . . . Prabhakaran, V. (2014). The influence of physiological noise correction on test-retest reliability of resting-state functional connectivity. Brain Connect, 4, 511–522. doi: https://doi.org/10.1089/brain.2014.0284
Braun, U., Plichta, M. M., Esslinger, C., Sauer, C., Haddad, L., Grimm, O., . . . Meyer-Lindenberg, A. (2012). Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures. Neuroimage, 59, 1404–1412. doi: https://doi.org/10.1016/j.neuroimage.2011.08.044
Buckner, R. L., Krienen, F. M., & Yeo, B. T. (2013). Opportunities and limitations of intrinsic functional connectivity MRI. Nat Neurosci, 16, 832–837. doi: https://doi.org/10.1038/nn.3423
Cabral, J., Hugues, E., Sporns, O., & Deco, G. (2011). Role of local network oscillations in resting-state functional connectivity. Neuroimage, 57, 130–139. doi: https://doi.org/10.1016/j.neuroimage.2011.04.010
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., . . . Nutt, D. J. (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A, 109, 2138–2143. doi: https://doi.org/10.1073/pnas.1119598109
Chang, L. J., Gianaros, P. J., Manuck, S. B., Krishnan, A., & Wager, T. D. (2015). A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect. PLoS Biol, 13, e1002180. doi: https://doi.org/10.1371/journal.pbio.1002180
Chase, H. W., Clos, M., Dibble, S., Fox, P., Grace, A. A., Phillips, M. L., & Eickhoff, S. B. (2015a). Evidence for an anterior-posterior differentiation in the human hippocampal formation revealed by meta-analytic parcellation of fMRI coordinate maps: focus on the subiculum. Neuroimage, 113, 44–60. doi: https://doi.org/10.1016/j.neuroimage.2015.02.069
Chase, H. W., Fournier, J. C., Greenberg, T., Almeida, J. R., Stiffler, R., Zevallos, C. R., . . . Phillips, M. L. (2015b). Accounting for Dynamic Fluctuations across Time when Examining fMRI Test-Retest Reliability: Analysis of a Reward Paradigm in the EMBARC Study. PLoS One, 10, e0126326. doi: https://doi.org/10.1371/journal.pone.0126326
Chase, H. W., Moses-Kolko, E. L., Zevallos, C., Wisner, K. L., & Phillips, M. L. (2013). Disrupted posterior cingulate-amygdala connectivity in postpartum depressed women as measured with resting BOLD fMRI. Soc Cogn Affect Neurosci. doi: nst083 [pii] 191093/scan/nst083
Chase, H. W., & Phillips, M. L. (2016). Elucidating neural network functional connectivity abnormalities in bipolar disorder: toward a harmonized methodological approach. Biol Psychiatry Cogn Neurosci Neuroimaging, 1, 288–298. doi: https://doi.org/10.1016/j.bpsc.2015.12.006
Chase, H. W., Segreti, A. M., Keller, T. A., Cherkassky, V. L., Just, M. A., Pan, L. A., & Brent, D. A. (2017). Alterations of functional connectivity and intrinsic activity within the cingulate cortex of suicidal ideators. J Affect Disord, 212, 78–85. doi: https://doi.org/10.1016/j.jad.2017.01.013
Cole, D. M., Smith, S. M., & Beckmann, C. F. (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Front Syst Neurosci, 4, 8. doi: https://doi.org/10.3389/fnsys.2010.00008
Cowen, P. J. (2008). Serotonin and depression: pathophysiological mechanism or marketing myth? Trends Pharmacol Sci. doi: S0165–6147(08)00126-0 [pii] 241016/j.tips.2008.05.004
De Havas, J. A., Parimal, S., Soon, C. S., & Chee, M. W. (2012). Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance. Neuroimage, 59, 1745–1751. doi: https://doi.org/10.1016/j.neuroimage.2011.08.026
Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., . . . Liston, C. (2017). Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nat Med, 23, 28–38. doi: https://doi.org/10.1038/nm.4246
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016). Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol Psychiatry, 21, 1358–1365. doi: https://doi.org/10.1038/mp.2015.168
Finn, E. S., Shen, X., Scheinost, D., Rosenberg, M. D., Huang, J., Chun, M. M., . . . Constable, R. T. (2015). Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nat Neurosci, 18, 1664–1671. doi: https://doi.org/10.1038/nn.4135
Fisher, P. M., Larsen, C. B., Beliveau, V., Henningsson, S., Pinborg, A., Holst, K. K., . . . Frokjaer, V. G. (2017). Pharmacologically Induced Sex Hormone Fluctuation Effects on Resting-State Functional Connectivity in a Risk Model for Depression: A Randomized Trial. Neuropsychopharmacology, 42, 446–453. doi: https://doi.org/10.1038/npp.2016.208
Fornito, A., Zalesky, A., & Breakspear, M. (2015). The connectomics of brain disorders. Nat Rev Neurosci, 16, 159–172. doi: https://doi.org/10.1038/nrn3901
Foss-Feig, J. H., Adkinson, B. D., Ji, J. L., Yang, G., Srihari, V. H., McPartland, J. C., . . . Anticevic, A. (2017). Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biol Psychiatry, 81, 848–861. doi: https://doi.org/10.1016/j.biopsych.2017.03.005
Fregnac, Y. (2003). Hebbian Synaptic Plasticity. In M. A. Arbib (Ed.), The Handbook of Brain Theory and Neural Networks (Second Edition ed., pp. 515–522). Cambridge, MA: The MIT Press.
Gabbay, V., Ely, B. A., Li, Q., Bangaru, S. D., Panzer, A. M., Alonso, C. M., . . . Milham, M. P. (2013). Striatum-based circuitry of adolescent depression and anhedonia. J Am Acad Child Adolesc Psychiatry, 52, 628–641 e613. doi: https://doi.org/10.1016/j.jaac.2013.04.003
Geerligs, L., Tsvetanov, K. A., Cam, C., & Henson, R. N. (2017). Challenges in measuring individual differences in functional connectivity using fMRI: The case of healthy aging. Hum Brain Mapp, 38, 4125–4156. doi: https://doi.org/10.1002/hbm.23653
Goense, J., Bohraus, Y., & Logothetis, N. K. (2016). fMRI at High Spatial Resolution: Implications for BOLD-Models. Front Comput Neurosci, 10, 66. doi: https://doi.org/10.3389/fncom.2016.00066
Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., . . . Etkin, A. (2015). Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry, 72, 305–315. doi: https://doi.org/10.1001/jamapsychiatry.2014.2206
Goodstein, D. L., & Goodstein, J. R. (1996). Feynman’s lost lecture : the motion of planets around the sun (1st ed.). New York: Norton.
Haaker, J., Menz, M. M., Fadai, T., Eippert, F., & Buchel, C. (2016). Dopaminergic receptor blockade changes a functional connectivity network centred on the amygdala. Hum Brain Mapp, 37, 4148–4157. doi: https://doi.org/10.1002/hbm.23302
Henckens, M. J., van Wingen, G. A., Joels, M., & Fernandez, G. (2012). Corticosteroid induced decoupling of the amygdala in men. Cereb Cortex, 22, 2336–2345. doi: https://doi.org/10.1093/cercor/bhr313
Horn, D. I., Yu, C., Steiner, J., Buchmann, J., Kaufmann, J., Osoba, A., . . . Walter, M. (2010). Glutamatergic and resting-state functional connectivity correlates of severity in major depression - the role of pregenual anterior cingulate cortex and anterior insula. Front Syst Neurosci, 4. doi: https://doi.org/10.3389/fnsys.2010.00033
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., . . . Wang, P. (2010). Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry, 167, 748–751. doi: 167/7/748 [pii] 421176/appi.ajp.2010.09091379
Johnen, V. M., Neubert, F. X., Buch, E. R., Verhagen, L., O’Reilly, J. X., Mars, R. B., & Rushworth, M. F. (2015). Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest. Elife, 4. doi: https://doi.org/10.7554/eLife.04585
Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D., & Pizzagalli, D. A. (2015). Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity. JAMA Psychiatry, 72, 603–611. doi: https://doi.org/10.1001/jamapsychiatry.2015.0071
Kerestes, R., Chase, H. W., Phillips, M. L., Ladouceur, C. D., & Eickhoff, S. B. (2017). Multimodal evaluation of the amygdala’s functional connectivity. Neuroimage, 148, 219–229. doi: https://doi.org/10.1016/j.neuroimage.2016.12.023
Klavir, O., Genud-Gabai, R., & Paz, R. (2013). Functional connectivity between amygdala and cingulate cortex for adaptive aversive learning. Neuron, 80, 1290–1300. doi: https://doi.org/10.1016/j.neuron.2013.09.035
Kragel, P. A., Knodt, A. R., Hariri, A. R., & LaBar, K. S. (2016). Decoding Spontaneous Emotional States in the Human Brain. PLoS Biol, 14, e2000106. doi: https://doi.org/10.1371/journal.pbio.2000106
Leaver, A. M., Espinoza, R., Joshi, S. H., Vasavada, M., Njau, S., Woods, R. P., & Narr, K. L. (2016). Desynchronization and Plasticity of Striato-frontal Connectivity in Major Depressive Disorder. Cereb Cortex, 26, 4337–4346. doi: https://doi.org/10.1093/cercor/bhv207
McCabe, C., & Mishor, Z. (2011). Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers. Neuroimage, 57, 1317–1323. doi: https://doi.org/10.1016/j.neuroimage.2011.05.051
Meng, C., Brandl, F., Tahmasian, M., Shao, J., Manoliu, A., Scherr, M., . . . Sorg, C. (2014). Aberrant topology of striatum’s connectivity is associated with the number of episodes in depression. Brain, 137, 598–609. doi: https://doi.org/10.1093/brain/awt290
Meunier, D., Lambiotte, R., Fornito, A., Ersche, K. D., & Bullmore, E. T. (2009). Hierarchical modularity in human brain functional networks. Front Neuroinform, 3, 37. doi: https://doi.org/10.3389/neuro.11.037.2009
Muller, V. I., Cieslik, E. C., Serbanescu, I., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2017). Altered Brain Activity in Unipolar Depression Revisited: Meta-analyses of Neuroimaging Studies. JAMA Psychiatry, 74, 47–55. doi: https://doi.org/10.1001/jamapsychiatry.2016.2783
Murphy, K., Birn, R. M., & Bandettini, P. A. (2013). Resting-state fMRI confounds and cleanup. Neuroimage, 80, 349–359. doi: https://doi.org/10.1016/j.neuroimage.2013.04.001
Murphy, K., Dixon, V., LaGrave, K., Kaufman, J., Risinger, R., Bloom, A., & Garavan, H. (2006). A validation of event-related FMRI comparisons between users of cocaine, nicotine, or cannabis and control subjects. Am J Psychiatry, 163, 1245–1251. doi: https://doi.org/10.1176/appi.ajp.163.7.1245
Murray, J. D., & Anticevic, A. (2017). Toward understanding thalamocortical dysfunction in schizophrenia through computational models of neural circuit dynamics. Schizophr Res, 180, 70–77. doi: https://doi.org/10.1016/j.schres.2016.10.021
Normann, C., Schmitz, D., Furmaier, A., Doing, C., & Bach, M. (2007). Long-term plasticity of visually evoked potentials in humans is altered in major depression. Biol Psychiatry, 62, 373–380. doi: https://doi.org/10.1016/j.biopsych.2006.10.006
Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008). A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry, 13, 829, 833–857. doi: https://doi.org/10.1038/mp.2008.65
Poline, J. B., & Brett, M. (2012). The general linear model and fMRI: does love last forever? Neuroimage, 62, 871–880. doi: https://doi.org/10.1016/j.neuroimage.2012.01.133
Posner, J., Hellerstein, D. J., Gat, I., Mechling, A., Klahr, K., Wang, Z., . . . Peterson, B. S. (2013). Antidepressants normalize the default mode network in patients with dysthymia. JAMA Psychiatry, 70, 373–382. doi: https://doi.org/10.1001/jamapsychiatry.2013.455
Price, R. B., Lane, S., Gates, K., Kraynak, T. E., Horner, M. S., Thase, M. E., & Siegle, G. J. (2017). Parsing Heterogeneity in the Brain Connectivity of Depressed and Healthy Adults During Positive Mood. Biol Psychiatry, 81, 347–357. doi: https://doi.org/10.1016/j.biopsych.2016.06.023
Renner, F., Siep, N., Arntz, A., van de Ven, V., Peeters, F., Quaedflieg, C., & Huibers, M. J. H. (2017). Negative mood-induction modulates default mode network resting-state functional connectivity in chronic depression. J Affect Disord, 208, 590–596. doi: https://doi.org/10.1016/j.jad.2016.10.022
Satpute, A. B., Kragel, P. A., Barrett, L. F., Wager, T. D., & Bianciardi, M. (2018). Deconstructing arousal into wakeful, autonomic and affective varieties. Neurosci Lett. doi: https://doi.org/10.1016/j.neulet.2018.01.042
Satterthwaite, T. D., Ciric, R., Roalf, D. R., Davatzikos, C., Bassett, D. S., & Wolf, D. H. (2017). Motion artifact in studies of functional connectivity: Characteristics and mitigation strategies. Hum Brain Mapp. doi: https://doi.org/10.1002/hbm.23665
Satterthwaite, T. D., Cook, P. A., Bruce, S. E., Conway, C., Mikkelsen, E., Satchell, E., . . . Sheline, Y. I. (2016). Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivity. Mol Psychiatry, 21, 894–902. doi: https://doi.org/10.1038/mp.2015.149
Scheinost, D., Holmes, S. E., DellaGioia, N., Schleifer, C., Matuskey, D., Abdallah, C. G., . . . Esterlis, I. (2017). Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology. doi: https://doi.org/10.1038/npp.2017.229
Schmaal, L., Hibar, D. P., Samann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., . . . Veltman, D. J. (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Mol Psychiatry, 22, 900–909. doi: https://doi.org/10.1038/mp.2016.60
Schmaal, L., Veltman, D. J., van Erp, T. G., Samann, P. G., Frodl, T., Jahanshad, N., . . . Hibar, D. P. (2016). Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry, 21, 806–812. doi: https://doi.org/10.1038/mp.2015.69
Shrout, P. E., & Fleiss, J. L. (1979). Intraclass correlations: uses in assessing rater reliability. Psychol Bull, 86, 420–428.
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., . . . Beckmann, C. F. (2009). Correspondence of the brain’s functional architecture during activation and rest. Proc Natl Acad Sci U S A, 106, 13040–13045. doi: https://doi.org/10.1073/pnas.0905267106
Treadway, M. T., & Zald, D. H. (2011). Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev, 35, 537–555. doi: https://doi.org/10.1016/j.neubiorev.2010.06.006
Trofimova, I., & Robbins, T. W. (2016). Temperament and arousal systems: A new synthesis of differential psychology and functional neurochemistry. Neurosci Biobehav Rev, 64, 382–402. doi: https://doi.org/10.1016/j.neubiorev.2016.03.008
Tsang, A., Lebel, C. A., Bray, S. L., Goodyear, B. G., Hafeez, M., Sotero, R. C., . . . Frayne, R. (2017). White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan. Front Aging Neurosci, 9, 144. doi: https://doi.org/10.3389/fnagi.2017.00144
van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H. (2008). Microstructural organization of the cingulum tract and the level of default mode functional connectivity. J Neurosci, 28, 10844–10851. doi: https://doi.org/10.1523/JNEUROSCI.2964-08.2008
van Wingen, G. A., Tendolkar, I., Urner, M., van Marle, H. J., Denys, D., Verkes, R. J., & Fernandez, G. (2014). Short-term antidepressant administration reduces default mode and task-positive network connectivity in healthy individuals during rest. Neuroimage, 88, 47–53. doi: https://doi.org/10.1016/j.neuroimage.2013.11.022
Varikuti, D. P., Hoffstaedter, F., Genon, S., Schwender, H., Reid, A. T., & Eickhoff, S. B. (2017). Resting-state test-retest reliability of a priori defined canonical networks over different preprocessing steps. Brain Struct Funct, 222, 1447–1468. doi: https://doi.org/10.1007/s00429-016-1286-x
Versace, A., Andreazza, A. C., Young, L. T., Fournier, J. C., Almeida, J. R., Stiffler, R. S., . . . Phillips, M. L. (2014). Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder. Mol Psychiatry, 19, 200–208. doi: https://doi.org/10.1038/mp.2012.188
Wang, C., Ong, J. L., Patanaik, A., Zhou, J., & Chee, M. W. (2016). Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states. Proc Natl Acad Sci U S A, 113, 9653–9658. doi: https://doi.org/10.1073/pnas.1523980113
Wang, L., Leonards, C. O., Sterzer, P., & Ebinger, M. (2014). White matter lesions and depression: a systematic review and meta-analysis. J Psychiatr Res, 56, 56–64. doi: https://doi.org/10.1016/j.jpsychires.2014.05.005
Wise, T., Radua, J., Nortje, G., Cleare, A. J., Young, A. H., & Arnone, D. (2016). Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder. Biol Psychiatry, 79, 293–302. doi: https://doi.org/10.1016/j.biopsych.2015.03.004
Wise, T., Radua, J., Via, E., Cardoner, N., Abe, O., Adams, T. M., . . . Arnone, D. (2017). Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. Mol Psychiatry, 22, 1455–1463. doi: https://doi.org/10.1038/mp.2016.72
Yang, G. J., Murray, J. D., Repovs, G., Cole, M. W., Savic, A., Glasser, M. F., . . . Anticevic, A. (2014). Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A, 111, 7438–7443. doi: https://doi.org/10.1073/pnas.1405289111
Zuo, X. N., & **ng, X. X. (2014). Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. Neurosci Biobehav Rev, 45, 100–118. doi: https://doi.org/10.1016/j.neubiorev.2014.05.009
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Chase, H.W. (2021). An Overview of Resting State Functional Connectivity Studies of Major Depressive Disorder. In: Diwadkar, V.A., B. Eickhoff, S. (eds) Brain Network Dysfunction in Neuropsychiatric Illness. Springer, Cham. https://doi.org/10.1007/978-3-030-59797-9_14
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