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Benign Epithelial Tumors of the Lung

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Diagnostic Thoracic Pathology

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Abstract

Benign tumors of the lung are much less common than malignant tumors with an incidence ranging from 1% to 5% of all lung tumors (Yoon et al. J Comput Assist Tomogr. 26:784–796, 2002). These neoplasms are generally small and depending on their site or origin can be associated with symptoms such as cough, postobstructive pneumonia, and hemoptysis if endobronchial in location or produce no symptoms if located in the peripheral lung parenchyma. Most of these tumors are mesenchymal in origin, mainly comprising hamartomas (Borczuk, Arch Pathol Lab Med. 132:1133–1148, 2008). Only a small subset of benign pulmonary tumors is epithelial in nature. Lack of familiarity with these tumors may lead to diagnostic challenges and potential misdiagnosis with significant consequences for patient care. In this chapter, a comprehensive review of benign epithelial tumors of the lung is presented along with discussion of the most important differential diagnosis. 

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References

  1. Yoon YC, Lee KS, Kim TS, et al. Benign bronchopulmonary tumors: radiologic and pathologic findings. J Comput Assist Tomogr. 2002;26:784–96.

    Article  PubMed  Google Scholar 

  2. Borczuk AC. Benign tumors and tumorlike conditions of the lung. Arch Pathol Lab Med. 2008;132:1133–48.

    Article  PubMed  Google Scholar 

  3. Drennan JM, Douglas AC. Solitary papilloma of a bronchus. J Clin Pathol. 1965;18:401–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Spencer H, Dail DH, Arneaud J. Non-invasive bronchial epithelial papillary tumors. Cancer. 1980;45:1486–97.

    Article  CAS  PubMed  Google Scholar 

  5. Roviaro GC, Varoli F, Pagnini CA. Is the solitary papilloma of the bronchus always a benign tumor? ORL J Otorhinolaryngol Relat Spec. 1981;43:301–8.

    Article  CAS  PubMed  Google Scholar 

  6. Salek J, Pazderka S, Zak F. Solitary bronchial polyps of inflammatory origin; a report of two cases treated by operation. J Thorac Surg. 1958;35:807–15.

    Article  CAS  PubMed  Google Scholar 

  7. Barzó P, Molnár L, Minik K. Bronchial papillomas of various origins. Chest. 1987;92:132–6.

    Article  PubMed  Google Scholar 

  8. Flieder DB, Koss MN, Nicholson A, et al. Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature. Am J Surg Pathol. 1998;22:1328–42.

    Article  CAS  PubMed  Google Scholar 

  9. Donne AJ, Hampson L, Homer JJ, et al. The role of HPV type in Recurrent Respiratory Papillomatosis. Int J Pediatr Otorhinolaryngol. 2010;74:7–14.

    Article  CAS  PubMed  Google Scholar 

  10. García-Milián R, Hernández H, Panadé L, et al. Detection and ty** of human papillomavirus DNA in benign and malignant tumours of laryngeal epithelium. Acta Otolaryngol. 1998;118:754–8.

    Article  PubMed  Google Scholar 

  11. Mounts P, Shah KV. Respiratory papillomatosis: etiological relation to genital tract papillomaviruses. Prog Med Virol. 1984;29:90–114.

    CAS  PubMed  Google Scholar 

  12. Popper HH, el-Shabrawi Y, Wöckel W, et al. Prognostic importance of human papilloma virus ty** in squamous cell papilloma of the bronchus: comparison of in situ hybridization and the polymerase chain reaction. Hum Pathol. 1994;25:1191–7.

    Article  CAS  PubMed  Google Scholar 

  13. Miura H, Tsuchida T, Kawate N, et al. Asymptomatic solitary papilloma of the bronchus: review of occurrence in Japan. Eur Respir J. 1993;6:1070–3.

    CAS  PubMed  Google Scholar 

  14. Oho K, Ogawa I, Amemiya R, et al. Indications for endoscopic Nd-YAG laser surgery in the trachea and bronchus. Endoscopy. 1983;15:302–6.

    Article  CAS  PubMed  Google Scholar 

  15. Kato H. Photodynamic therapy for early stage central type of lung cancer. Mayo Clin Proc. 1997;72:688–90.

    Article  CAS  PubMed  Google Scholar 

  16. Basheda S, Gephardt GN, Stoller JK. Columnar papilloma of the bronchus. Case report and literature review. Am Rev Respir Dis. 1991;144:1400–2.

    Article  CAS  PubMed  Google Scholar 

  17. Harada H, Miura K, Tsutsui Y, et al. Solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis. Pathol Int. 2000;50:431–9.

    Article  CAS  PubMed  Google Scholar 

  18. Hasegawa Y, Sato N, Niikawa H, et al. Lung squamous cell carcinoma arising in a patient with adult-onset recurrent respiratory papillomatosis. Jpn J Clin Oncol. 2013;43:78–82.

    Article  PubMed  Google Scholar 

  19. Kawaguchi T, Matumura A, Iuchi K, et al. Solitary squamous papilloma of the bronchus associated with human papilloma virus type 11. Intern Med. 1999;38:817–9.

    Article  CAS  PubMed  Google Scholar 

  20. Katial RK, Ranlett R, Whitlock WL. Human papilloma virus associated with solitary squamous papilloma complicated by bronchiectasis and bronchial stenosis. Chest. 1994;106:1887–9.

    Article  CAS  PubMed  Google Scholar 

  21. Jackson DA, Hatch HB. Solitary benign squamous papilloma of the bronchus. Report of two cases. Am Rev Respir Dis. 1968;97:699–705.

    CAS  PubMed  Google Scholar 

  22. Liebow AA. Tumors of lower respiratory tract. An atlas. Sect 5, vol. 17. Washington DC: Armed Forces Institute of Pathology; 1952. p. 22.

    Google Scholar 

  23. Vaccarezza OA, Mannini L, Boretti JJ. Bronchial adenoma. Dis Chest. 1968;53:372.

    Article  CAS  PubMed  Google Scholar 

  24. Weiss L, Ingram M. Adenomatoid bronchial tumors. A consideration of the carcinoid tumors and the salivary tumors of the bronchial tree. Cancer. 1961;14:161–78.

    Article  CAS  PubMed  Google Scholar 

  25. Emory WB, Mitchell WT Jr, Hatch HB Jr. Mucous gland adenoma of the bronchus. Am Rev Respir Dis. 1973;108:1407–10.

    CAS  PubMed  Google Scholar 

  26. England DM, Hochholzer L. Truly benign “bronchial adenoma”. Report of 10 cases of mucous gland adenoma with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 1995;19:887–99.

    Article  CAS  PubMed  Google Scholar 

  27. Kwon JW, Goo JM, Seo JB, et al. Mucous gland adenoma of the bronchus: CT findings in two patients. J Comput Assist Tomogr. 1999;23:758–60.

    Article  CAS  PubMed  Google Scholar 

  28. Alp M, Uçanok K, Doğan R, et al. Surgical treatment of bronchial adenomas: results of 29 cases and review of the literature. Thorac Cardiovasc Surg. 1987;35:290–4.

    Article  CAS  PubMed  Google Scholar 

  29. Moran CA, Suster S, Askin FB, et al. Benign and malignant salivary gland-type mixed tumors of the lung. Clinicopathologic and immunohistochemical study of eight cases. Cancer. 1994;73:2481–90.

    Article  CAS  PubMed  Google Scholar 

  30. Karpathiou G, Sivridis E, Mikroulis D, et al. Pulmonary mucus gland adenomas: are they always of endobronchial localization? Case Rep Pathol. 2013;2013:239173.

    PubMed  PubMed Central  Google Scholar 

  31. Yousem SA, Hochholzer L. Alveolar adenoma. Hum Pathol. 1986;17:1066–71.

    Article  CAS  PubMed  Google Scholar 

  32. Al-Hilli F. Lymphangioma (or alveolar adenoma?) of the lung. Histopathology. 1987;11:979–80.

    Article  CAS  PubMed  Google Scholar 

  33. Semeraro D, Gibbs AR. Pulmonary adenoma: a variant of sclerosing haemangioma of lung? J Clin Pathol. 1989;42:1222–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Oliveira P, Moura Nunes JF, Clode AL, et al. Alveolar adenoma of the lung: further characterization of this uncommon tumour. Virchows Arch. 1996;429:101–8.

    CAS  PubMed  Google Scholar 

  35. Burke LM, Rush WI, Khoor A, et al. Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases. Hum Pathol. 1999;30:158–67.

    Article  CAS  PubMed  Google Scholar 

  36. Hartman MS, Epstein DM, Geyer SJ, et al. Alveolar adenoma. Ann Thorac Surg. 2004;78:1842–3.

    Article  PubMed  Google Scholar 

  37. Böhm J, Fellbaum C, Bautz W, et al. Pulmonary nodule caused by an alveolar adenoma of the lung. Virchows Arch. 1997;430:181–4.

    Article  PubMed  Google Scholar 

  38. Cakan A, Samancilar O, Nart D, et al. Alveolar adenoma: an unusual lung tumor. Interact Cardiovasc Thorac Surg. 2003;2:345–7.

    Article  PubMed  Google Scholar 

  39. Halldorsson A, Dissanaike S, Kaye KS. Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour. J Clin Pathol. 2005;58:1211–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Fujimoto K, Müller NL, Sadohara J, et al. Alveolar adenoma of the lung: computed tomography and magnetic resonance imaging findings. J Thorac Imaging. 2002;17:163–6.

    Article  PubMed  Google Scholar 

  41. Sak SD, Koseoglu RD, Demirag F, et al. Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature. APMIS. 2007;115:1443–9.

    Article  PubMed  Google Scholar 

  42. Nakamura H, Adachi Y, Arai T, et al. A small alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Surg. 2009;87:956–7.

    Article  PubMed  Google Scholar 

  43. Bhavsar T, Uppal G, Travaline JM, et al. An unusual case of a microscopic alveolar adenoma coexisting with lung carcinoma: a case report and review of the literature. J Med Case Rep. 2011;5:187.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Kondo N, Torii I, Hashimoto M, et al. Alveolar adenoma of the lung: a case report. Ann Thorac Cardiovasc Surg. 2011;17:71–3.

    Article  PubMed  Google Scholar 

  45. Nosotti M, Mendogni P, Rosso L, et al. Alveolar adenoma of the lung: unusual diagnosis of a lesion positive on PET scan. A case report. J Cardiothorac Surg. 2012;7:1.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Wang L, Wang X, Rustam A, et al. Alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2013;19:489–91.

    Article  PubMed  Google Scholar 

  47. Petrella F, Rizzo S, Pelosi G, et al. Giant alveolar adenoma causing severe dyspnoea. J Thorac Oncol. 2010;5:1088–90.

    Article  PubMed  Google Scholar 

  48. Cavazza A, Paci M, De Marco L, et al. Alveolar adenoma of the lung: a clinicopathologic, immunohistochemical, and molecular study of an unusual case. Int J Surg Pathol. 2004;12:155–9.

    Article  PubMed  Google Scholar 

  49. De Rosa N, Maiorino A, De Rosa I, et al. CD34 expression in the stromal cells of alveolar adenoma. Case Rep Med. 2012;2012:913517.

    PubMed  PubMed Central  Google Scholar 

  50. Noguchi M, Kodama T, Shimosato Y, et al. Papillary adenoma of type 2 pneumocytes. Am J Surg Pathol. 1986;10:134–9.

    Article  CAS  PubMed  Google Scholar 

  51. Yamamoto T, Horiguchi H, Shibagaki T, et al. Encapsulated type II pneumocyte adenoma: a case report and review of the literature. Respiration. 1993;60:373–7.

    Article  CAS  PubMed  Google Scholar 

  52. Fantone JC, Geisinger KR, Appelman HD. Papillary adenoma of the lung with lamellar and electron dense granules. An ultrastructural study. Cancer. 1982;50:2839–44.

    Article  CAS  PubMed  Google Scholar 

  53. Hegg CA, Flint A, Singh G. Papillary adenoma of the lung. Am J Clin Pathol. 1992;97:393–7.

    Article  CAS  PubMed  Google Scholar 

  54. Cornejo KM, Shi M, Akalin A, et al. Pulmonary papillary adenoma: a case report and review of the literature. J Bronchol Interv Pulmonol. 2013;20:52–7.

    Article  Google Scholar 

  55. Mori M, Chiba R, Tezuka F, et al. Papillary adenoma of type II pneumocytes might have malignant potential. Virchows Arch. 1996;428:195–200.

    Article  CAS  PubMed  Google Scholar 

  56. Kuwahara M, Nagafuchi M, Rikimaru T, et al. Pulmonary papillary adenoma. Gen Thorac Cardiovasc Surg. 2010;58:542–5.

    Article  PubMed  Google Scholar 

  57. Dessy E, Braidotti P, Del Curto B, et al. Peripheral papillary tumor of type-II pneumocytes: a rare neoplasm of undetermined malignant potential. Virchows Arch. 2000;436:289–95.

    Article  CAS  PubMed  Google Scholar 

  58. Neusuess A, Claviez A, Schroeter T, et al. Synchronous detection of a pulmonary papillary adenoma and lung metastases in a patient with osteosarcoma in relapse. Med Pediatr Oncol. 2002;38:125–7.

    Article  PubMed  Google Scholar 

  59. Allen TC, Amrikachi M, Cagle PT. Pulmonary sclerosing papillary adenoma. Pathol Int. 2013;63:364–7.

    Article  PubMed  Google Scholar 

  60. Sheppard MN, Burke L, Kennedy M. TTF-1 is useful in the diagnosis of pulmonary papillary adenoma. Histopathology. 2003;43:404–5.

    Article  CAS  PubMed  Google Scholar 

  61. Nakano T, Yokose T, Hasegawa C, et al. Papillary adenoma of the lung with a peculiar raw macroscopic feature. Pathol Int. 2011;61:475–80.

    Article  PubMed  Google Scholar 

  62. Ishikawa Y. Ciliated muconodular papillary tumor of the peripheral lung: benign or malignant? Pathol Clin Med (Byouri-to-Rinsho). 2002;20:964–5.

    Google Scholar 

  63. Kamata T, Yoshida A, Kosuge T, et al. Ciliated muconodular papillary tumors of the lung: a clinicopathologic analysis of 10 cases. Am J Surg Pathol. 2015;39:753–60.

    Article  PubMed  Google Scholar 

  64. Ishikawa M, Sumitomo S, Imamura N, et al. Ciliated muconodular papillary tumor of the lung: report of five cases. J Surg Case Rep. 2016;2016(8)

    Google Scholar 

  65. Kon T, Baba Y, Fukai I, et al. Ciliated muconodular papillary tumor of the lung: a report of five cases. Pathol Int. 2016;66:633–9.

    Article  PubMed  Google Scholar 

  66. Aida S, Ohara I, Shimazaki H, et al. Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases. Am J Surg Pathol. 2008;32:1489–94.

    Article  PubMed  Google Scholar 

  67. Emerson LL, Layfield LJ. Solitary peripheral pulmonary papilloma evaluation on frozen section: a potential pitfall for the pathologist. Pathol Res Pract. 2012;208:726–9.

    Article  PubMed  Google Scholar 

  68. Kaseda K, Horio H, Harada M, et al. Solitary glandular papilloma of the peripheral lung: a report of two cases. World J Surg Oncol. 2014;12:149.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Nakamura S, Koshikawa T, Sato T, et al. Extremely well differentiated papillary adenocarcinoma of the lung with prominent cilia formation. Acta Pathol Jpn. 1992;42:745–50.

    CAS  PubMed  Google Scholar 

  70. Choi KH, Baek HA, Park HS, et al. Sclerosing hemangioma, presenting as a pneumonic pattern with mucinous adenomatous hyperplasia of the lung. Pathol Int. 2008;58:735–40.

    Article  PubMed  Google Scholar 

  71. Chuang HW, Liao JB, Chang HC, et al. Ciliated muconodular papillary tumor of the lung: a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: a case report and review of literature. Pathol Int. 2014;64:352–7.

    Article  CAS  PubMed  Google Scholar 

  72. Kamata T, Sunami K, Yoshida A, et al. Frequent BRAF or EGFR Mutations in Ciliated Muconodular Papillary Tumors of the Lung. J Thorac Oncol. 2016;11:261–5.

    Article  PubMed  Google Scholar 

  73. Liu L, Aesif SW, Kipp BR, et al. Ciliated muconodular papillary tumors of the lung can occur in western patients and show mutations in BRAF and AKT1. Am J Surg Pathol. 2016;40:1631–6.

    Article  PubMed  Google Scholar 

  74. ** Y, Shen X, Shen L, et al. Ciliated muconodular papillary tumor of the lung harboring ALK gene rearrangement: case report and review of the literature. Pathol Int. 2017;67:171–5.

    Article  CAS  PubMed  Google Scholar 

  75. Liebow AA, Hubbell DS. Sclerosing hemangioma (histiocytoma, xanthoma) of the lung. Cancer. 1956;9:53–75.

    Article  CAS  PubMed  Google Scholar 

  76. Katzenstein AL, Weise DL, Fulling K, et al. So-called sclerosing hemangioma of the lung. Evidence for mesothelial origin. Am J Surg Pathol. 1983;7:3–14.

    Article  CAS  PubMed  Google Scholar 

  77. Huszar M, Suster S, Herczeg E, et al. Sclerosing hemangioma of the lung. Immunohistochemical demonstration of mesenchymal origin using antibodies to tissue-specific intermediate filaments. Cancer. 1986;58:2422–7.

    Article  CAS  PubMed  Google Scholar 

  78. Devouassoux-Shisheboran M, Hayashi T, Linnoila RI, et al. A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. Am J Surg Pathol. 2000;24:906–16.

    Article  CAS  PubMed  Google Scholar 

  79. Xu HM, Li WH, Hou N, et al. Neuroendocrine differentiation in 32 cases of so-called sclerosing hemangioma of the lung: identified by immunohistochemical and ultrastructural study. Am J Surg Pathol. 1997;21:1013–22.

    Article  CAS  PubMed  Google Scholar 

  80. Wu J, Zhang C, Qiao H. The significance of p40 expression in sclerosing hemangioma of lung. Sci Rep. 2014;4:6102.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Schmidt LA, Myers JL, McHugh JB. Napsin A is differentially expressed in sclerosing hemangiomas of the lung. Arch Pathol Lab Med. 2012;136:1580–4.

    Article  CAS  PubMed  Google Scholar 

  82. Rossi G, Cadioli A, Mengoli MC, et al. Napsin A expression in pulmonary sclerosing haemangioma. Histopathology. 2012;60:361–3.

    Article  PubMed  Google Scholar 

  83. Yamazaki K. Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. Virchows Arch. 2004;445:45–53.

    CAS  PubMed  Google Scholar 

  84. Tanaka I, Inoue M, Matsui Y, et al. A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis. Jpn J Clin Oncol. 1986;16:77–86.

    CAS  PubMed  Google Scholar 

  85. Niho S, Suzuki K, Yokose T, et al. Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. Am J Pathol. 1998;152:1065–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Sartori G, Bettelli S, Schirosi L, et al. Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung. Am J Surg Pathol. 2007;31:1512–20.

    Article  PubMed  Google Scholar 

  87. Wang E, Lin D, Wang Y, Wu G, et al. Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. Hum Pathol. 2004;35:503–8.

    Article  CAS  PubMed  Google Scholar 

  88. Spencer H, Nambu S. Sclerosing haemangiomas of the lung. Histopathology. 1986;10:477–87.

    Article  CAS  PubMed  Google Scholar 

  89. Shin SY, Kim MY, Oh SY, et al. Pulmonary sclerosing pneumocytoma of the lung: CT characteristics in a large series of a tertiary referral center. Medicine (Baltimore). 2015;94:e498.

    Article  Google Scholar 

  90. Miyagawa-Hayashino A, Tazelaar HD, Langel DJ, et al. Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. Arch Pathol Lab Med. 2003;127:321–5.

    Article  PubMed  Google Scholar 

  91. Katzenstein AL, Gmelich JT, Carrington CB. Sclerosing hemangioma of the lung: a clinicopathologic study of 51 cases. Am J Surg Pathol. 1980;4:343–56.

    Article  CAS  PubMed  Google Scholar 

  92. Maeda R, Isowa N, Miura H, et al. Bilateral multiple sclerosing hemangiomas of the lung. Gen Thorac Cardiovasc Surg. 2009;57:667–70.

    Article  PubMed  Google Scholar 

  93. Lee ST, Lee YC, Hsu CY, et al. Bilateral multiple sclerosing hemangiomas of the lung. Chest. 1992;101:572–3.

    Article  CAS  PubMed  Google Scholar 

  94. Hanaoka J, Ohuchi M, Inoue S, et al. Bilateral multiple pulmonary sclerosing hemangioma. Jpn J Thorac Cardiovasc Surg. 2005;53:157–61.

    Article  PubMed  Google Scholar 

  95. Soumil VJ, Navin B, Sangeeta D, et al. Multiple sclerosing hemangiomas of the lung. Asian Cardiovasc Thorac Ann. 2004;12:357–9.

    Article  PubMed  Google Scholar 

  96. Neuman J, Rosioreanu A, Schuss A, et al. Radiology-pathology conference: sclerosing hemangioma of the lung. Clin Imaging. 2006;30:409–12.

    Article  PubMed  Google Scholar 

  97. Wang QB, Chen YQ, Shen JJ, et al. Sixteen cases of pulmonary sclerosing haemangioma: CT findings are not definitive for preoperative diagnosis. Clin Radiol. 2011;66:708–14.

    Article  PubMed  Google Scholar 

  98. Devouassoux-Shisheboran M, de la Fouchardière A, Thivolet-Béjui F, et al. Endobronchial variant of sclerosing hemangioma of the lung: histological and cytological features on endobronchial material. Mod Pathol. 2004;17:252–7.

    Article  PubMed  Google Scholar 

  99. Kim KH, Sul HJ, Kang DY. Sclerosing hemangioma with lymph node metastasis. Yonsei Med J. 2003;44:150–4.

    Article  PubMed  Google Scholar 

  100. Chan AC, Chan JK. Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): a new clue to its histogenesis. Am J Surg Pathol. 2000;24:1531–6.

    Article  CAS  PubMed  Google Scholar 

  101. Yano M, Yamakawa Y, Kiriyama M, et al. Sclerosing hemangioma with metastases to multiple nodal stations. Ann Thorac Surg. 2002;73:981–3.

    Article  PubMed  Google Scholar 

  102. Komatsu T, Fukuse T, Wada H, et al. Pulmonary sclerosing hemangioma with pulmonary metastasis. Thorac Cardiovasc Surg. 2006;54:348–9.

    Article  CAS  PubMed  Google Scholar 

  103. Wei S, Tian J, Song X, et al. Recurrence of pulmonary sclerosing hemangioma. Thorac Cardiovasc Surg. 2008;56:120–2.

    Article  CAS  PubMed  Google Scholar 

  104. Wani Y, Notohara K, Tsukayama C, et al. Sclerosing hemangioma with florid endobronchial and endobronchiolar growth. Virchows Arch. 2007;450:221–3.

    Article  PubMed  Google Scholar 

  105. Khoury JD, Shephard MN, Moran CA. Cystic sclerosing haemangioma of the lung. Histopathology. 2003;43:239–43.

    Article  CAS  PubMed  Google Scholar 

  106. Moran CA, Zeren H, Koss MN. Sclerosing hemangioma of the lung. Granulomatous variant. Arch Pathol Lab Med. 1994;118:1028–30.

    CAS  PubMed  Google Scholar 

  107. Yousem SA, Wick MR, Singh G, et al. So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin. Am J Surg Pathol. 1988;12:582–90.

    CAS  PubMed  Google Scholar 

  108. Rodriguez-Soto J, Colby TV, Rouse RV. A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. Am J Surg Pathol. 2000;24:442–50.

    Article  CAS  PubMed  Google Scholar 

  109. Ohori NP, Yousem SA, Sonmez-Alpan E, et al. Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung. Am J Clin Pathol. 1991;96:529–35.

    Article  CAS  PubMed  Google Scholar 

  110. Leong AS, Chan KW, Seneviratne HS. A morphological and immunohistochemical study of 25 cases of so-called sclerosing haemangioma of the lung. Histopathology. 1995;27:121–8.

    Article  CAS  PubMed  Google Scholar 

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  1. Associate Professor, Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Annikka Weissferdt

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Weissferdt, A. (2020). Benign Epithelial Tumors of the Lung. In: Diagnostic Thoracic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-36438-0_11

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