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Cellular and Molecular Mechanisms of Atherosclerosis

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Heart of the Matter

Part of the book series: Learning Materials in Biosciences ((LMB))

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Abstract

This chapter will comprehensively discuss the underlying pathophysiology of atherosclerosis: a disease of global importance, focusing particularly on the role of immune and smooth muscle cells. We will then explore current research surrounding factors that may contribute to plaque instability and subsequent haemorrhage, including novel theories regarding the potential role of various macrophage subsets. Finally, we will examine atherosclerosis at a signalling level, expanding upon the role of inflammatory recruitment pathways and its constituent molecules.

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Author information

Authors and Affiliations

  1. Imperial College London, London, UK

    Adam Tsao & Mridul Rana

  2. National Heart and Lung Institute, Vascular Sciences, Imperial College London, London, UK

    Joseph J. Boyle

Authors
  1. Adam Tsao
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  2. Mridul Rana
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  3. Joseph J. Boyle
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Corresponding author

Correspondence to Joseph J. Boyle .

Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College London, London, UK

    Cesare Terracciano

  2. Imperial College London & St George’s Medical School, London, UK

    Samuel Guymer

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Tsao, A., Rana, M., Boyle, J.J. (2019). Cellular and Molecular Mechanisms of Atherosclerosis. In: Terracciano, C., Guymer, S. (eds) Heart of the Matter. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-24219-0_17

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