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Development of the Enteric Nervous System

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Hirschsprung's Disease and Allied Disorders

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Abstract

The development of the enteric nervous system (ENS) requires the complex interaction of genes encoding transcription factors, signalling molecules and their receptors. Normal ENS development is based on survival of neural crest-derived cells and their coordinated proliferation, movement and differentiation into neurons and glia. These processes are influenced by the microenvironment of the develo** gut. Alterations in gene function, defects in neural crest cells or changes in the gut microenvironment may result in abnormal development of the ENS.

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Authors and Affiliations

  1. Department of Paediatric Surgery and Paediatric Urology, Goethe-University Frankfurt/M., Frankfurt/M., Germany

    Udo Rolle

  2. National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland

    Prem Puri

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  1. Udo Rolle
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  2. Prem Puri
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Correspondence to Udo Rolle .

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  1. National Children’s Research Centre, Our Lady’s Childrens Hospital, University College Dublin, Dublin, Ireland

    Prem Puri

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Rolle, U., Puri, P. (2019). Development of the Enteric Nervous System. In: Puri, P. (eds) Hirschsprung's Disease and Allied Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-15647-3_2

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