Abstract
Transcriptional regulatory circuits are often complex, consisting of many components and regulatory interactions. Mathematical modeling is an important tool for understanding the behavior of these circuits, and identifying gaps in our understanding of gene regulation. Ordinary differential equations (ODEs) are a commonly used formalism for constructing mathematical models of complex regulatory networks. Here, I outline the steps involved in develo**, parameterizing, and testing an ODE model of a gene regulatory network.
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Seaton, D.D. (2017). ODE-Based Modeling of Complex Regulatory Circuits. In: Kaufmann, K., Mueller-Roeber, B. (eds) Plant Gene Regulatory Networks. Methods in Molecular Biology, vol 1629. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7125-1_20
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DOI: https://doi.org/10.1007/978-1-4939-7125-1_20
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