Abstract
MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology—as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV–miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV–miRNA interactions using miRWalk and TargetScan databases.
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Acknowledgements
This work was funded by the Research Council through Graduiertenkolleg 886 and by the German Federal Ministry of Research and Education through the National Genome Research Network (NGFN-2, Grant no. 01GR 0450).
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Dweep, H., Gretz, N., Felekkis, K. (2014). A Schematic Workflow for Collecting Information About the Interaction Between Copy Number Variants and MicroRNAs Using Existing Resources. In: Alvarez, M., Nourbakhsh, M. (eds) RNA Map**. Methods in Molecular Biology, vol 1182. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1062-5_26
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DOI: https://doi.org/10.1007/978-1-4939-1062-5_26
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