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The Interplay Between White Matter, Mitochondria, and Neuroprotection

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White Matter Injury in Stroke and CNS Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 4))

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Abstract

The relationship between white matter injury (WMI) and mitochondrial dysfunction (either within neurons or glia) is emerging as a sophisticated synergistic interconnection that has only recently begun to be investigated. In a recent shift away from the traditional neurocentric view of the brain, the new Gestalt perspective of the CNS embraces the intercellular interactions between grey matter and white matter and their substantial dependence on mitochondria for survival. In addition, the variations in mitochondrial activity and dynamics between cell types may underlie inherent differences in vulnerability between glial and neural cells. Thus, the newer questions on the interplay between white matter, mitochondria, and neurons are themselves complex. First, what are the implications of mitochondrial dysfunction within white matter cells themselves, and second, what is the global impact of WMI on mitochondrial function within neuronal cells? To address these questions, the present review describes the nature of mitochondria in neurons and glia and examines their functional roles. We then explore the impact of WMI on mitochondria and neuronal fate. Finally, the possibility that white matter diseases are closely related to mitochondrial disorders is considered, with reference to the conspicuous overlap in their clinical presentations.

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Authors and Affiliations

  1. Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    R. Anne Stetler Ph.D., Zheng **g Ph.D., **aoming Hu Ph.D., Guodong Cao Ph.D. & Jun Chen M.D.

  2. State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University Shanghai Medical College, Shanghai, China

    R. Anne Stetler Ph.D., **aoming Hu Ph.D., Yanqin Gao M.D., Guodong Cao Ph.D. & Jun Chen M.D.

  3. Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA

    R. Anne Stetler Ph.D., Zheng **g Ph.D., **aoming Hu Ph.D., Guodong Cao Ph.D. & Jun Chen M.D.

  4. Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA, USA

    Rehana K. Leak Ph.D.

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  1. R. Anne Stetler Ph.D.
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  2. Rehana K. Leak Ph.D.
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  3. Zheng **g Ph.D.
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Correspondence to Jun Chen M.D. .

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Editors and Affiliations

  1. Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Selva Baltan

  2. Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA

    S. Thomas Carmichael

  3. Departamento de Neurociencias, Achucarro Basque Centger for Neuroscience, University del Pais Vasco (UPV/EHU), and Centro de, Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Leioa, Spain

    Carlos Matute

  4. University of Michigan Dept. Neurosurgery, Ann Arbor, Michigan, USA

    Guohua **

  5. Dept. Pharmacology Dept. Neurosurgery, Loma Linda University Dept. Physiology, Loma Linda, California, USA

    John H Zhang

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Stetler, R.A. et al. (2014). The Interplay Between White Matter, Mitochondria, and Neuroprotection. In: Baltan, S., Carmichael, S., Matute, C., **, G., Zhang, J. (eds) White Matter Injury in Stroke and CNS Disease. Springer Series in Translational Stroke Research, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9123-1_22

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