Abstract
The Hippo pathway is a conserved signaling pathway that mediates tissue and organ growth, and is commonly deregulated in diseases such as cancer. A series of phosphorylation events and protein interactions propagate Hippo pathway signaling and culminate in the modulation of the transcriptional regulators TAZ and YAP. The majority of effort to date has focused on identifying new players in the pathway and understanding the transcriptional processes regulated by TAZ and YAP. However, it has become clear that the ramifications of Hippo pathway activity extend well beyond that of transcriptional regulation. Hippo pathway components have been implicated in a wide-range of processes that range from the organization of cell polarity to the fine-tuning of morphogen signaling. This chapter highlights some of the non-canonical roles for the Hippo pathway and discusses how these functions influence organogenesis and disease.
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Acknowledgements
Work in XV’s laboratory is supported in part by Research Grant No. 5-FY11-578 from the March of Dimes Foundation and by funds from the Concern Cancer Foundation.
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Varelas, X. (2013). Non-canonical Roles for the Hippo Pathway. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_17
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Print ISBN: 978-1-4614-6219-4
Online ISBN: 978-1-4614-6220-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)