Abstract
Autophagy is a cellular survival mechanism influenced by a wide variety of intracellular and extracellular stresses including energy and oxygen deprivation, signaling aberrancies, ER stress, DNA damage, systemic cancer therapies, and radiotherapies. There is growing evidence that it may potentiate cancer survival. A number of clinical trials have been launched using autophagy inhibition in combination with standard cancer therapeutics. The information gleaned from these as well as ongoing in vitro and in vivo studies will allow us to better understand the role of autophagy in cancer.
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Rangwala, R., Amaravadi, R. (2013). The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting. In: Johnson, D. (eds) Cell Death Signaling in Cancer Biology and Treatment. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5847-0_4
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