Abstract
T cell lymphomas are a heterogeneous group of neoplasms with variable clinical presentations, morphologic patterns, phenotypes and underlying genetic abnormalities. They are divided into precursor T cell (lymphoblastic) neoplasms of thymic origin and peripheral T-cell lymphomas (PTCL). According to the WHO classification, the latter comprise malignant tumors derived from post-thymic T cells and those derived natural killer (NK) cells. This heterogeneous group accounts for about 10–15 % of all lymphomas in most Western countries with a great geographic variation [1], being more prevalent in Asia at least partly reflecting the involvement of viruses in their pathogenesis such as human T lymphotrophic virus type 1 (HTLV-1) and Epstein–Barr virus (EBV). PTCLs are, with few exceptions, aggressive neoplasms with a poor response to therapy and a uniformly dismal prognosis [2].
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References
Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124–30.
de Leval L, Gaulard P. Pathology and biology of peripheral T-cell lymphomas. Histopathology. 2011;58:49–68.
Khokhar FA, Payne WD, Talwalkar SS, Jorgensen JL, Bueso-Ramos CE, Medeiros LJ, et al. Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study. Hum Pathol. 2010;41:79–87.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. Mature T- and NK cell neoplasms, Chap. 11: WHO classification of tumours of haematopoietic and lymphoid tissue. 4th ed. Lyon: IARC; 2008. p. 269–321.
Dogan A, Morice WG. Bone marrow histopathology in peripheral T-cell lymphomas. Br J Haematol. 2004;127:140–54.
Vega F, Medeiros LJ, Bueso-Ramos C, Jones D, Lai R, Luthra R, et al. Hepatosplenic gamma/delta T-cell lymphoma in bone marrow. A sinusoidal neoplasm with blastic cytologic features. Am J Clin Pathol. 2001;16:410–9.
Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, et al. Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the international peripheral T-cell lymphoma project. Blood. 2011;117:3402–8.
Fend F, Kremer M. Diagnosis and classification of malignant lymphoma and related entities in the bone marrow trephine biopsy. Pathobiology. 2007;74:133–43.
Ghani AM, Krause JR. Bone marrow biopsy findings in angioimmunoblastic lymphadenopathy. Br J Haematol. 1985;61:203–13.
Gaulard P, Kanavaros P, Farcet JP, Rocha FD, Haioun C, Divine M, et al. Bone marrow histologic and immunohistochemical findings in peripheral. T-cell lymphoma: a study of 38 cases. Hum Pathol. 1991;22:331–8.
Sakai H, Tanaka H, Katsurada T, Yoshida Y, Okamoto E, Ohno H. Angioimmunoblastic T-cell lymphoma initially presenting with replacement of bone marrow and peripheral plasmacytosis. Intern Med. 2007;46:419–24.
Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Huh J. Distinct features of angioimmunoblastic T-cell lymphoma with bone marrow involvement. Am J Clin Pathol. 2009;131:640–6.
Grogg KL, Morice WG, Macon WR. Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphoma. Br J Haematol. 2007;137:416–22.
Baseggio L, Traverse-Glehen A, Berger F, Ffrench M, Jallades L, Morel D, et al. CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma. Mod Pathol. 2011;24:993–1003.
Savage KJ, Harris NL, Vose JM, Ullrich F, Jaffe ES, Connors JM, et al. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the international peripheral T-cell lymphoma project. Blood. 2008;15(111):5496–504.
Lamant L, McCarthy K, d’Amore E, Klapper W, Nakagawa A, Fraga M et al. Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. J Clin Oncol. 2011;29:4669–76.
Bayle C, Charpentier A, Duchayne E, Manel AM, Pages MP, Robert A, et al. Leukaemic presentation of small cell variant anaplastic large cell lymphoma: report of four cases. Br J Haematol. 1999;104:680–8.
Piccaluga PP, Agostinelli C, Gazzola A, Mannu C, Bacci F, Sabattini E, et al. Prognostic markers in peripheral T-cell lymphoma. Curr Hematol Malig Rep. 2010;5:222–8.
Bain B, Clark DM, Lampert I, Wilkins BS. Bone marrow pathology, Chap. 3. 3rd ed. Oxford: Blackwell science; 2001. p. 114.
Thiele J, Zirbes TK, Kvasnicka HM, Fischer R. Focal lymphoid aggregates (nodules) in bone marrow biopsies: differentiation between benign hyperplasia and malignant lymphoma – a practical guideline. J Clin Pathol. 1999;52:294–300.
Gaulard P, de Leval L. Follicular helper T cells: implications in neoplastic hematopathology. Semin Diagn Pathol. 2011;28:202–13.
Powers ML, Watson BW, Frater JL, Kreisel F, Hassan A. Peripheral eosinophilia camouflaging anaplastic large cell lymphoma. Int J Surg Pathol. 2011;19:405–8.
Allory Y, Challine D, Haioun C, Copie-Bergman C, Delfau-Larue MH, Boucher E, et al. Bone marrow involvement in lymphomas with hemophagocytic syndrome at presentation: a clinicopathologic study of 11 patients in a Western institution. Am J Surg Pathol. 2001;25:865–74.
Firkin F, Schneider H, Grill V. Parathyroid hormone-related protein in hypercalcemia associated with hematological malignancy. Leuk Lymphoma. 1998;29:499–506.
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Gaulard, P., Hoeller, S. (2012). Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas. In: Anagnostou, D., Matutes, E. (eds) Bone Marrow Lymphoid Infiltrates. Springer, London. https://doi.org/10.1007/978-1-4471-4174-7_14
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DOI: https://doi.org/10.1007/978-1-4471-4174-7_14
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