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Genetics and Family History of Alcohol Use Disorders

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Translational Research Methods for Alcohol Use Disorders

Part of the book series: Neuromethods ((NM,volume 201))

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Abstract

Alcohol use disorders (AUD) are complex traits that are moderately heritable. A variety of approaches have been developed that allow researchers to better understand their genetic etiology. We cover several approaches for incorporating information on family history and genetic risk into research on AUD. Latent genetic designs leverage information from biological relatives. The classic twin design helps to understand population variability in AUD, while other approaches using family data can be applied to better understand individual risk. Measured genotypic approaches, such as genome-wide association studies (GWAS), use information from the entire genome to identify individual variants associated with risk for AUD. GWAS results can then be transformed into aggregate measures of individual risk in the form of polygenic scores (PGS) in non-overlap** samples. We discuss specific approaches to these methods, various considerations for each, and the limitations with currently available tools.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Peter B. Barr & Jacquelyn L. Meyers

  2. VA New York Harbor Healthcare System, Brooklyn, NY, USA

    Peter B. Barr & Jacquelyn L. Meyers

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  1. Peter B. Barr
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Correspondence to Peter B. Barr .

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  1. Department of Psychology, Indiana University – Purdue University, Indianapolis, IN, USA

    Melissa A. Cyders

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Barr, P.B., Meyers, J.L. (2023). Genetics and Family History of Alcohol Use Disorders. In: Cyders, M.A. (eds) Translational Research Methods for Alcohol Use Disorders. Neuromethods, vol 201. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3267-3_1

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