Abstract
Recently an explosion in the discovery of long noncoding RNAs (lncRNAs) was obtained by high-throughput sequencing. Genome-wide transcriptome analyses, in conjugation with research for epigenetic modifications of chromatins, identified a novel type of non–protein coding transcripts longer than 200 nucleotides named lncRNAs . They are gradually emerging as functional and critical participants in many physiological processes. Here we gave an overview of the characteristics, biological functions, and working mechanism for this new class of noncoding RNA molecules.
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Acknowledgments
This work was supported, in whole or in part, by The National Key Research and Development Program of China 2017YFA0105501 (X. Z.), The National Natural Science Foundation of China 81302262 (X. Z.), and The Science and Technology Project of Guangdong Province 2015A020212019 (X. Z.). We apologize to scientists whose work was not discussed here due to space constraints.
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Zhang, D., Wu, M., **ong, M., Xu, C., **ang, P., Zhong, X. (2021). Long Noncoding RNAs: An Overview. In: Zhang, L., Hu, X. (eds) Long Non-Coding RNAs. Methods in Molecular Biology, vol 2372. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1697-0_23
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DOI: https://doi.org/10.1007/978-1-0716-1697-0_23
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