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Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy

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Progress in Medical Research

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1070))

Abstract

Literature reports on the very high frequency (VHF) range of 0.4–0.9 Hz in heart rate variability (HRV) are scanty. The VHF presence in cardiac transplant patients and other conditions associated with reduced vagal influence on the heart encouraged us to explore this spectral band in healthy subjects and in patients diagnosed with cardiac autonomic neuropathy (CAN), and to assess the potential clinical value of some VHF indices. The study included 80 healthy controls and 48 patients with spinocerebellar ataxia type 2 (SCA2) with CAN. The electrocardiographic recordings of short 5-min duration were submitted to three different spectral analysis methods, including the most generally accepted procedure, and the two novel methods using the Hilbert-Huang transform. We demonstrated the presence of VHF activity in both groups of subjects. However, VHF power spectral density, expressed in relative normalized units, was significantly greater in the SCA2 patients than that in healthy subjects, amounting to 36.1 ± 17.4% vs. 22.9 ± 14.1%, respectively, as also was the instantaneous VHF spectral frequency, 0.58 ± 0.05 vs. 0.64 ± 0.07 Hz, respectively. These findings were related to the severity of CAN. We conclude that VHF activity of HRV is integral to the cardiovascular autonomic control.

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Acknowledgments

The authors’ thanks go to the Laboratory of Signals and Nonlinear Dynamics of the University of Entre Ríos in the Republic of Argentina, especially to Marcelo A. Colominas and Profs. Gastón Schlotthauer and María E. Torres for their splendid work in the development and modifications of the CEEMDAN methods, with the corresponding implementations in Matlab, downloaded from https: www.bioingenieria.edu.ar/grupos/ldnlys for use in the present study.

Competing Interests

The authors declare that they have no competing interests in relation to this article.

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Authors and Affiliations

  1. Institute of Neurology and Neurosurgery, Havana, Cuba

    Mario Estévez-Báez & Calixto Machado

  2. General Hospital ‘Ernesto Guevara de la Serna’, Las Tunas, Cuba

    Julio Montes-Brown

  3. Latin American School of Medicine, Havana, Cuba

    Julio Montes-Brown

  4. Center for Sports Research, Havana, Cuba

    Javier Jas-García

  5. Faculty of Social Welfare and Health Science, University of Haifa, Haifa, Israel

    Gerry Leisman

  6. National Institute for Brain and Rehabilitation Sciences, Nazareth, Israel

    Gerry Leisman

  7. University of the Medical Sciences, ‘Manuel Fajardo’ Medical School, Havana, Cuba

    Gerry Leisman

  8. Anesthesiology and Critical Care Medicine, Neurosciences Critical Care Division, Johns Hopkins Hospital, Baltimore, MD, USA

    Adam Schiavi

  9. Department of Biology, University of Havana, Havana, Cuba

    Andrés Machado-García & Claudia Carricarte-Naranjo

  10. Physical Therapy Department, Faculty of Social Welfare and Health Science, University of Haifa, Haifa, Israel

    Eli Carmeli

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  1. Mario Estévez-Báez
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Correspondence to Gerry Leisman .

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  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Estévez-Báez, M. et al. (2018). Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy. In: Pokorski, M. (eds) Progress in Medical Research. Advances in Experimental Medicine and Biology(), vol 1070. Springer, Cham. https://doi.org/10.1007/5584_2018_154

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