Search
Search Results
-
Endothelial dysfunction: mechanisms and contribution to diseases
The endothelium, lining the inner surface of blood vessels and spanning approximately 3 m 2 , serves as the largest organ in the body. Comprised of...
-
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages...
-
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions...
-
Drug repurposing based on the DTD-GNN graph neural network: revealing the relationships among drugs, targets and diseases
MotivationThe rational modelling of the relationship among drugs, targets and diseases is crucial for drug retargeting. While significant progress...
-
Emerging diseases: trend research and omics-based analysis reveals mechanisms of endophytes modulate Chilli plant resilience
Chili pepper, widely recognized as a popular spice and an important cash crop worldwide, faces significant threats from climate change-related...
-
Ferroptosis: mechanisms and advances in ocular diseases
As an essential trace element in the body, iron is critical for the maintenance of organismal metabolism. Excessive iron facilitates reactive oxygen...
-
Integrative analyses and validation of ferroptosis-related genes and mechanisms associated with cerebrovascular and cardiovascular ischemic diseases
BackgroundThere has been a gradual increase in the occurrence of cardiovascular and cerebrovascular ischemic diseases, particularly as comorbidities....
-
The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy
The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly...
-
Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future
Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and their risk factors contribute to high morbidity and a high rate...
-
Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases
BackgroundF. nucleatum , as an important periodontal pathogen, is not only closely associated with the development of periodontitis, but also...
-
Phlorotannins from brown algae: a review on their antioxidant mechanisms and applications in oxidative stress-mediated diseases
Phlorotannins are polyphenolic compounds that are exclusively derived from marine brown algae. The molecular structure of phlorotannins with numerous...
-
Connecting omics signatures and revealing biological mechanisms with iLINCS
There are only a few platforms that integrate multiple omics data types, bioinformatics tools, and interfaces for integrative analyses and...
-
Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases
BackgroundFlavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a...
-
Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1...
-
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in...
-
Precise genome-editing in human diseases: mechanisms, strategies and applications
Precise genome-editing platforms are versatile tools for generating specific, site-directed DNA insertions, deletions, and substitutions. The...
-
Genome analysis of Shewanella putrefaciens 4H revealing the potential mechanisms for the chromium remediation
Microbial remediation of heavy metal polluted environment is ecofriendly and cost effective. Therefore, in the present study, Shewanella putrefaciens ...
-
Pregnancy Loss and Cardiovascular Diseases in Women: Recent Findings and Potential Mechanisms
Purpose of ReviewPregnancy loss (PL) has been acknowledged by the American Heart Association as a risk factor for cardiovascular diseases (CVD) later...
-
Alternative autophagy: mechanisms and roles in different diseases
As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged...
-
Revealing grapevine (Vitis vinifera L.) defense mechanisms against biotic stress: insights from transcriptomic analysis and systems biology
Biotic stress leads to enormous yield, quality, and economic losses in grapevine ( Vitis vinifera L.). However, the crucial genes and underlying...
